Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases was approved to establish by Shanghai Committee of Science and Technology in 2014, with Professor Wu Hao as the director. Supported by Shanghai Jiaotong University School of Medicine and Shanghai Ninth People's Hospital, the Key Laboratory brings together a group of top scientists and young talents in otology and audiology. Currently, there are 8 doctoral tutors, 4 master tutors and 3 adjunct professors. In recent years, it has got many grants from National Program on Key Basic Research (973 Program), National Key Research and Development Plan, Key Program of National Natural Science Foundation of China, Major Program of Shanghai Committee of Science and Technology, etc, with over 200 SCI papers published in international academic journals. It received National Grade Ⅱ Prize of Science and Technology Progress in 2018 and Grade Ⅰ Prize of Science and Technology Progress Award of National Ministry of Education in 2019.The Key Laboratory focuses on the basic and translational research of otology and audiology medicine, and has successively established 6 technology platforms, include gene sequencing platform, auditory electrophysiological platform, auditory ultrastructural platform, mass spectrometry platform, bioimaging platform and biobank of hearing loss. It owns an international first-class experimental facility and research team. Take the research of “Sensorineural Hearing Loss and Reestablish” as the core, we aim to pursuit key scientific quests on prevention and treatment of sensorineural hearing loss. With focuses on structural and functional basis of auditory signaling process, we want to elucidate the physiopathological mechanism behind hearing impairment, to discover targets of pharmaceutical and gene therapies, to develop artificial hearing implantation device, and to achieve restoration of hearing.