Biography

• In XIA Shujie career life, He found new pathogenesis of benign prostatic hyperplasia and established innovative theory of anatomic repair of prostate wound to functional recovery after surgery. Furthermore based on this theory, he establish trans-urethral thulium laser enucleation of the prostate (ThuLEP), and it make the individualized therapeutic plan decisions based on the personal volume of prostate possible. This technique received praise from Professor Stavros Gravas, a famous expert of F1000 and it was record in EAU guideline and many urological textbooks. Moreover, based on the need of innovative theory and precise surgical system, he independently invented domestic thulium-laser therapeutic machine and developed the “Group standard for Thulium laser Therapeutic Machine and Guidelines for Clinical Application”,to normalize the promotion of  technique. In recent years, He establish the theory, “mesenchymal stem cell was activated by mechanical force biological chain”, and new therapeutic mode to treat incontinence and erectile dysfunction. In near two decades, Shujie Xia and his team do enomous contribution to urology and got compliment from domestic and international urological society. With these contribution help, He build the top-class urological department of the Chinese hospitals and perform outstanding BPH surgery around the world.

Publications

1. Liu S, Jiang C, Hu J, Chen H, Han B, Xia S. Low-Intensity Pulsed Ultrasound Enhanced Adipose-Derived Stem Cell-Mediated Angiogenesis in the Treatment of Diabetic Erectile Dysfunction through the Piezo-ERK-VEGF Axis. Stem Cells Int. 2022 Jul 29;2022:6202842. (IF:5.131)

2. Sun M, Deng Z, Shi F, Zhou Z, Jiang C, Xu Z, Cui X, Li W, Jing Y, Han B, Zhang W, Xia S. Rebamipide-loaded chitosan nanoparticles accelerate prostatic wound healing by inhibiting M1 macrophage-mediated inflammation via the NF-kappa B signaling pathway [J]. Biomaterials Science, 2020, 8(3): 912-25.(TOP8 publication in MATERIALS SCIENCE, BIOMATERIALS,IF: cited by 42)

3. Zhao R, Wang X, Jiang C, Shi F, Zhu Y, Yang B, Zhuo J, Jing Y, Luo G, Xia S, Han B. Finasteride accelerates prostate wound healing after thulium laser resection through DHT and AR signalling [J]. Cell Proliferation, 2018, 51(3).(IF:8.755, cited by 12)

4. Deng Z, Sun M, Zhu Y, Zhuo J, Zhao F, Xia S, Han B, Herrmann T R W. Thulium laser VapoResection of the prostate versus traditional transurethral resection of the prostate or transurethral plasmakinetic resection of prostate for benign prostatic obstruction: a systematic review and meta-analysis [J]. World Journal of Urology, 2018, 36(9): 1355-64.(IF: 3.661 cited by 11)

5. Wang X-J, Zhuo J, Luo G-H, Zhu Y-P, Yu D-J, Zhao R-Z, Jiang C-Y, Shi Y-F, Li H, Chen L, Hao K-Y, Han X, Zhao S, Bei X-Y, Jing Y-F, Xia S-J. Androgen Deprivation Accelerates the Prostatic Urethra Wound Healing After Thulium Laser Resection of the Prostate by Promoting Re-Epithelialization and Regulating the Macrophage Polarization [J]. Prostate, 2017, 77(7): 708-17.(IF:4.104, cited by 15 )

6. Cui D, Sun F, Zhuo J, Sun X, Han B, Zhao F, Jing Y, Lu J, Xia S. A randomized trial comparing thulium laser resection to standard transurethral resection of the prostate for symptomatic benign prostatic hyperplasia: four-year follow-up results [J]. World Journal of Urology, 2014, 32(3): 683-9.(IF:4.226; cited by 37)

7. Wang X, Lin WJ, Izumi K, Jiang Q, Lai KP, Xu D, Fang LY, Lu T, Li L, Xia S, Chang C. Increased infiltrated macrophages in benign prostatic hyperplasia (BPH): role of stromal androgen receptor in macrophage-induced prostate stromal cell proliferation.[J]. Journal of Biological Chemistry, 2012, 287(22): 18376-85.(IF: 5.157,cited by 53)

8. Xia S-J, Zhuo J, Sun X-W, Han B-M, Shao Y, Zhang Y-N. Thulium laser versus standard transurethral resection of the prostate: A randomized prospective trial [J]. European Urology, 2008, 53(2): 382-90.(IF:20.096, cited by 239)

9. Huirong Chen, Zheng Li, Xianchen Li, Yong Yang, Yutian Dai, Zuogang Xie, Jiaquan Xiao, Xiaoqiang Liu, Luo Yang, Chenkun Shi, Erlei Zhi, Ruhui Tian, Peng Li, Huixing Chen, Fujun Zhao, Jianlin Hu, Chencheng Yao, Guiting Lin, Tom F. Lue, Shujie Xia,The Efficacy and Safety of Thrice vs Twice per Week Low-Intensity Pulsed Ultrasound Therapy for Erectile Dysfunction: A Randomized Clinical Trial,The Journal of Sexual Medicine,2022，

10. Shi F, Deng Z, Zhou Z, Jiang B, Jiang CY, Zhao RZ, Sun F, Cui D, Sun MH, Sun Q, Wang XJ, Wu Q, Xia SJ, Han BM. Heat injured stromal cells-derived exosomal EGFR enhances prostatic wound healing after thulium laser resection through EMT and NF-κB signaling. Prostate. 2019 Aug;79(11):1238-1255. (IF:4.104, Cited by 8)