Biography

• Main associations: ISHNE BOT, FACC, FHRS, FESC, FEHRA, member of the Standing Committee of Cardiac Electrophysiology and Pacing Society of the Chinese Medical Association, Chairman of Shanghai Atrial Fibrillation Center Alliance, President of the Cardiovascular Society of Shanghai Stroke Association

• Developed and created a remote ECG diagnostic system with an annual diagnostic service volume of 1 million person times.

• Established a variety of innovative diagnosis methods and technical innovations for complex arrhythmias, confirmed that (1) reentry is the mechanism of ventricular tachycardia originating from the aortic sinus; (2) bundle branch reentrant ventricular tachycardia can occur in patients with normal HV interval during sinus rhythm; (3) premature beat originating from Purkinje fibers is an important mechanism to induce ventricular fibrillation and so on.

• Innovated the optimization of cardiac electrical and structural remodeling, confirmed that the cardiac patch based on aligned carbon nanotube film has a good application prospect in cardiac resynchronization therapy.

• Established renal denervation (RDN), a non-invasive denervation method for the treatment of hypertension.

• Innovated and led a one-stop strategy of combined catheter ablation of atrial fibrillation (AF) and left atrial appendage closure procedure for AF treatment and stroke prevention.

• Led the compilation of the ”White Paper on Standardized Diagnosis and Treatment of Atrial Fibrillation in Shanghai” and “Shanghai Municipal Standard for Hierarchical medicine of Atrial Fibrillation.

• Editor-in-chief of 3 monographs; Obtained 2 key projects of the National Natural Science Foundation of China, 5 general projects and a number of Shanghai Science and Technology Commission projects.

Publications

1. Mu Chen, Cheng Li, Peng Liao, Xin Cui, Wen-qi Tian, Qun-shan Wang, Jian Sun, Mei Yang, Li Luo, Hong Wu, and Yi-Gang Li. Epidemiology, management, and outcomes of atrial fibrillation among 30 million citizens in Shanghai,China from 2015 to 2020: A medical insurance database study. Lancet Regional Health - Western Pacific.2022;23: 100470 .IF =8.559.

2. Zhi-Xing Wei , Yu-Dong Fei , Qian Wang , Jian-Wen Hou , Xing-Xing Cai , Yu-Li Yang , Tai-Zhong Chen , Quan-Fu Xu , Yue-Peng Wang  and Yi-Gang Li . Loss of Camk2n1 aggravates cardiac remodeling and malignant ventricular arrhythmia after myocardial infarction in mice via NLRP3 inflammasome activation. Free Radical Biology and Medicine. 2021 May 1;167:243-257. IF=8.101

3. Mei Yang , Run-Ze Zhou , Xiang-Jun Qiu , Xiang-Hei Feng , Jian Sun , Qun-Shan Wang , Qiu-Fen Lu , Peng-Pai Zhang , Bo Liu , Wei Li , Mu Chen , Yan Zhao , Bin-Feng Mo , Xin Zhou , Xi Zhang , Ying-Xue Hua , Jin Guo , Fang-Fang Bi , Ya-Jun Cao , Feng Ling , Sheng-Ming Shi and Yi-Gang Li . Artificial intelligence-assisted analysis on the association between exposure to ambient fine particulate matter and incidence of arrhythmias in outpatients of Shanghai community hospitals. Environment International. 2020 Jun; doi: 10.1016/j.envint.2020.105745. IF=13.352

4. Yi-He Chen , Hui Lin , Qian Wang , Jian-Wen Hou , Zhi-Jie Mao and Yi-Gang Li .  Protective role of silibinin against myocardial ischemia/reperfusion injury-induced cardiac dysfunction. International Journal of Biological Sciences. 2020 Apr 27;16(11):1972-1988. IF=10.75（通讯82）

5. Xing-Xing Cai , Yu-Li Yang , Yichen Shen , Wei Wang , Li Qian , Jing Cai , Run-Min Chi , Yu-Dong Fei , Shun-Xuan Yu , Le Wei , Jian-Wen Hou , Qian Wang , Jian-Guo Zhang , Deng-Bin Wang , Ma-Wei Jiang  and Yi-Gang Li . Noninvasive Stereotactic Body Radiotherapy for Renal Denervation in a Swine Model. Journal of the American College of Cardiology 2019;74:1697–1709. IF=27.203.

6. Yu-Dong Fei , Qian Wang , Jian-Wen Hou , Wei Li , Xing-Xing Cai , Yu-Li Yang , Liu-Hui Zhang , Zhi-Xing Wei , Tai-Zhong Chen , Yue-Peng Wang and Yi-Gang Li . Macrophages facilitate post myocardial infarction arrhythmias: roles of gap junction and KCa3.1. Theranostics 2019;9(22):6396-6411. IF=11.6.

7. Jian-Wen Hou , Yu-Dong Fei , Wei Li , Yi-He Chen , Qian Wang , Ying Xiao, Yue-Peng Wang and Yi-Gang Li . The transient receptor potential melastatin 4 channel inhibitor 9-phenanthrol modulates cardiac sodium channel. British Journal of Pharmacology 2018;175(23):4325-4337. IF=9.473.

8. Qing Zhou , Si-Si Wei , Hong Wang , Qian Wang , Wei Li , Gang Li , Jian-Wen Hou , Xiao-Meng Chen , Jie Chen , Wei-Ping Xu , Yi-Gang Li and Yue-Peng Wang. Crucial Role of ROCK2-Mediated Phosphorylation and Upregulation ofFHOD3 in the Pathogenesis of Angiotensin II-Induced Cardiac Hypertrophy. Hypertension 2017;69(6):1070-1083. IF=9.897.

9. Qian Wang , Ying Yu , Peng-Pai Zhang , Yi-He Chen, Chang-Yi Li, Jie Chen, Yue-Peng Wang  and Yi-Gang Li . The crucial role of activin A/ALK4 pathway in the pathogenesis of Ang-II-induced atrial fibrosis and vulnerability to atrial fibrillation. Basic Research in Cardiology 2017;112(4): 47-63. IF=12.416.

10. Jing Ren , Quanfu Xu , Xiao-Meng Chen , Wei Li , Kai Guo , Yang Zhao , Qian Wang , Zhi-Tao Zhang , Hui-Sheng Peng  and Yi-Gang Li . Superaligned Carbon Nanotubes Guide Oriented Cell Growth and Promote Electrophysiological Homogeneity for Synthetic Cardiac Tissues. Advanced Materials 2017;29(44). IF=32.086.

11. Ji-Fang Ma , Fan Yang , Saagar N Mahida , Ling Zhao , Xiao-Min Chen , Michael L Zhang , Zhi-Jun Sun , Yan Yao , Yi-Xin Zhang , Gu-Yan Zheng , Jie Dong , Ming-Jun Feng , Rui Zhang , Jian Sun , Shuo Li , Qun-Shan Wang , Hui-Qing Cao , Emelia J Benjamin , Patrick T Ellinor , Yi-Gang Li and Xiao-Li Tian . TBX5 mutations contribute to early-onset atrial fibrillation in Chinese and Caucasians. Cardiovascular Research 2016;109: 442-450. IF=13.081.

12. Chang-Yi Li , Qing Zhou , Ling-Chao Yang , Yi-He Chen , Jian-Wen Hou , Kai Guo , Yue-Peng Wang and Yi-Gang Li . Dual-specificity phosphatase 14 protects the heart from aortic banding-induced cardiac hypertrophy and dysfunction through inactivation of TAK1-P38MAPK/-JNK1/2 signaling pathway. Basic Research in Cardiology 2016;111(2):19. IF=12.416.