Tier 2 Professors

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ZHENG MinHua

Professor

Email: zmhtiger@yeah.net

Tel: 021-

Research Interests: 1. The minimally invasive treatment of gastrointestinal tumors, the optimization, and standardization of laparoscopic gastrointestinal tumor surgery-related surgical methods.

2. The development and clinical application of endoscopic robotic arm and 4k/3D fluorescent laparoscopy, and application of artificial intelligence in minimally invasive surgery.

3. The mechanisms related to drug resistance and metastasis of gastrointestinal tumors. Such as, the influence of epigenetic inheritance on gastrointestinal tumor metastasis, and the potential application of cell death (pyroptosis, ion-induced cell death) in cancer treatment.

Biography

  • Professor Minhua Zheng assumes the director of General Surgery Department, director of Gastrointestinal Surgery Department, Ruijin Hospital affiliated to Shanghai JiaoTong University, School of Medicine. He is also the director of Shanghai Minimally Invasive Surgery Center. He holds the post of Chinese Society of Laparo-Endoscopic Surgery (CSLES), governor of Endoscopic and Laparoscopic Surgeon of Asia (ELSA), board member of International Federation of Societies of Endoscopic Surgeons (IFSES),fellow of the Royal College of Surgeons of England(FRCS). As one of the leading experts in minimally invasive surgery of gastrointestinal cancer, Professor Minhua Zheng has been long engaged in clinical and research work. He serves as the chief editor of Annals of Laparoscopic and Endoscopic Surgery, deputy chief editor of Chinese Journal of Digestive Surgery, etc.

Publications

  1. Zheng M, Boni L, Uranues S, Chen WT, Fingerhut A. Academic surgery amid the COVID-19 pandemic: A perspective of the present and future challenges. Int J Surg. 2022;104:106726. doi:10.1016/j.ijsu.2022.106726

  2. Xu L, Su X, He Z, et al. Short-term outcomes of complete mesocolic excision versus D2 dissection in patients undergoing laparoscopic colectomy for right colon cancer (RELARC): a randomised, controlled, phase3, superiority trial. Lancet Oncol. 2021;22(3):391-401. doi:10.1016/S1470-2045(20)30685-9

  3. Yalikun A, Ma J, Zheng M, Zang L: ASO Author Reflections: Totally Laparoscopic Distal Gastrectomy with Modified Billroth-II with Braun Reconstruction Could Be Technically Feasible and Effective in Preventing Bile Reflux. Ann Surg Oncol 2022, 29(4):2368-2369.

  4. Aikemu Batuer,Shao Yanfei,Yang Guang et al. NDRG1 regulates Filopodia-induced Colorectal Cancer invasiveness via modulating CDC42 activity.[J] .Int J Biol Sci, 2021, 17: 1716-1730.

  5. Cai Zhenghao,Song Haiqin,Fingerhut Abe et al. A greater lymph node yield is required during pathological examination in microsatellite instability-high gastric cancer.[J] .BMC Cancer, 2021, 21: 319.

  6. Yalikun Abudushalamu,Aikemu Batuer,Li Shuchun et al. A Modified Billroth-II with Braun Anastomosis in Totally Laparoscopic Distal Gastrectomy: Initial Experience Compared with Roux-en-Y Anastomosis.[J] .Ann Surg Oncol, 2022, 29: 2359-2367.

  7. Yalikun A, Aikemu B, Li S, Zhang T, Ma J, Zheng M, Zang L: ASO Visual Abstract: A Modified Billroth-II with Braun Anastomosis in Totally Laparoscopic Distal Gastrectomy—Initial Experience Compared with Roux-en-Y Anastomosis. Annals of Surgical Oncology 2022, 29(4):2370-2370.

  8. Jiang Tian-Yu,Zang Lu,Dong Feng et al. Effect of different reinforcement methods on anastomotic leakage prevention after laparoscopic double anastomosis.[J] .J Surg Oncol, 2021, null: S81-S87.

  9. Cai Zhenghao,Ma Junjun,Li Shuchun et al. Impact of microsatellite status on negative lymph node count and prognostic relevance after curative gastrectomy.[J] .J Surg Oncol, 2021, null: S15-S24.

  10. Yang Guang,Huang Ling,Jia Hongtao et al. NDRG1 enhances the sensitivity of cetuximab by modulating EGFR trafficking in colorectal cancer.[J] .Oncogene, 2021, 40: 5993-6006.

  11. Zheng MH, Boni L, Fingerhut A Minimally invasive surgery and the novel coronavirus outbreak: lessons learned in China and Italy Annals of Surgery 2020

  12. Cai ZH, Rui WW, Li SC, Fingerhut A, Sun J, Ma JJ, Zang L, Zhu ZG, Zheng MH Microsatellite status affects tumor response and survival in patients undergoing neoadjuvant chemotherapy for clinical stage Ⅲ gastric cancer: Frontiers in Oncology, section Gastrointestinal Cancers

  13. Zhang LY, Ma JJ, Zang L, Hong HJ, Fingerhut A, Zheng MH Staged laparoscopic management for locally advanced gastric cancer with outlet obstruction J Surg Oncol 2020

  14. Hong HJ, Zhao X, Yu CR, Sun J, Dong F, Zang L, Lu AG, Feng B, Wang ML,  Yu MH, Qiu XJ, Qian BY, Xie L, Fingerhut A, Zheng MH, Ma JJ, Zhong M Comparative study of oncologic efficacy of cephalo-medial to lateral dissection vs. medial to lateral dissection in laparoscopic total mesorectal excision for rectal cancer: a RCT study Ann Surg Oncol 2021

  15. Cai ZH, Ma JJ, Li SC, Fingerhut A, Sun J, Zang L, Zhu ZG, Zheng MH Impact of microsatellite status on negative lymph node count and prognostic relevance after curative gastrectomy Journal of Surgical Oncology 2021

  16. Cai ZH, Song H, Fingerhut A, Sun J, Ma JJ, Zhang L, Li SC, Yu C, Zheng MH, Zang L A greater lymph node yield is required during pathological examination in microsatellite instability-high gastric cancer BMC Cancer 2021

  17. Yang X, Liu M, Li M, et al. Epigenetic modulations of noncoding RNA: a novel dimension of Cancer biology[J]. Mol Cancer, 2020, 19(1): 64.

  18. Yang X, Zhang S, He C, et al. METTL14 suppresses proliferation and metastasis of colorectal cancer by down-regulating oncogenic long non-coding RNA XIST[J]. Mol Cancer, 2020, 19(1): 46.

  19. Zhang S, Yu C, Yang X, et al. N-myc downstream-regulated gene 1 inhibits the proliferation of colorectal cancer through emulative antagonizing NEDD4-mediated ubiquitylation of p21[J]. Journal of experimental & clinical cancer research : CR, 2019, 38(1): 490.

  20. Yu C, Hao X, Zhang S, Hu W, Li J, Sun J, Zheng M. Characterization of the prognostic values of the NDRG family in gastric cancer. Therap Adv Gastroenterol. 2019 Jul 21;12:1756284819858507.

  21. Pan R, Cai W, Sun J, Yu C, Li P, Zheng M. Inhibition of KHSRP sensitizes colorectal cancer to 5-fluoruracil through miR-501-5p-mediated ERRFI1 mRNA degradation. J Cell Physiol. 2019 Jul 16. doi: 10.1002/jcp.29076.

  22. Yu C, Hong H, Zhang S, Zong Y, Ma J, Lu A, Sun J, Zheng M1. Identification of key genes and pathways involved in microsatellite instability in colorectal cancer. Mol Med Rep. 2019 Mar;19(3):2065-2076.

  23. He Z, Zhang S, Xue P, Yan X, Zhou L, Li J, Wang M, Lu A, Ma J, Zang L, Hong H, Dong F, Su H, Sun J, Zhang L, Zheng M, Feng B*. Completely medial access by page-turning approach for laparoscopic right hemi-colectomy: 6-year-experience in single center. Surg Endosc. 2019 Mar;33(3):959-965. doi: 10.1007/s00464-018-6525-1.

  24. Yu C, Hong H, Lu J, Zhao X, Hu W, Zhang S, Zong Y, Mao Z, Li J, Wang M, Feng B, Sun J, Zheng M. Prediction of Target Genes and Pathways Associated With Cetuximab Insensitivity in Colorectal Cancer. Technol Cancer Res Treat. 2018 Jan 1;17:1533033818806905.

  25. Yu C, Xue P, Zhang L, Pan R, Cai Z, He Z, Sun J, Zheng M. Prediction of key genes and pathways involved in trastuzumab-resistant gastric cancer. World J Surg Oncol. 2018 Aug 22;16(1):174.

  26. Mi L, Zhu F, Yang X, Lu J, Zheng Y, Zhao Q, Wen X, Lu A, Wang M*, Zheng M*, Ji J, Sun J*, The metastatic suppressor NDRG1 inhibits EMT, migration and invasion through interaction and promotion of caveolin-1 ubiquitylation in human colorectal cancer cells, Oncogene, 2017, 36(30): 4323-4335

  27. Feng B, Lu JY, Zhang S, Zheng MH. Laparoscopic abdominoperineal resection with trans-abdominal individualized levator transection: interim analysis of a randomized controlled trial[J]. Colorectal Dis. 2017 Jul;19(7):O246-O252

  28. Cai Z, Pan R, Ma J, et al. Tumor Localization for Laparoscopic Colorectal Resection Without Endoscopic Tattooing[J]. Surgical Laparoscopy Endoscopy & Percutaneous Techniques, 2016, 26.

  29. Song H, Kang X, Sun J, et al. Nanoparticle delivery of sterically hindered platinum(iv) prodrugs shows 100 times higher potency than that of cisplatin upon light activation.[J]. Chemical Communications, 2016, 52(11):2281-2283.

  30. Lu J, Jiao T, Li Y, et al. Facilitating retroflexed endoscopic full-thickness resection through loop-mediated or rope-mediated countertraction (with videos)[J]. Gastrointestinal Endoscopy, 2016, 83(1):223-228.