Biography

• PI, Head of High-Throughput Sequencing Platform, National Translational Medicine Center (Shanghai), Ruijin Hospital affiliated to the Medical School of Shanghai Jiao Tong University.

• 1983 Medical School of Shanghai Jiao Tong University，Medicine, Bachelor of Medicine;

• 2000 University of Antwerp, Biochemistry, Doctor of Science;

• 1983-1990 Shanghai No.6 People’s hospital, Pediatrician；

• 2001-2017 Chines National Human Genome Center, Assistant Director, Prof. ,PI；

• 2018-Now National Translational Medicine Center (Shanghai), Ruijin Hospital affiliated to the Medical School of Shanghai Jiao Tong University, Head of the High-Throughput Sequencing Platform, Prof., PI；

• Engaged in the research on genomics, functional genomics and epigenomics of model organisms, pathogens, genetic diseases and tumors for decades. In recent years, focusing on the integrated analysis of tumor multi genomics, studied the genetic basis of genomic structure and functional variation in tumor occurrence and development, illustrated the pathological mechanism of ALL drug resistance recurrence in children with PRPS mutation for the first time. Undertaken a dozen of the international cooperation and national genome projects, such as “973” “863” “Key R&D Program “ projects. Published more than 100 papers in Nature, Science, Nature Genetics, Nature Medicine and other international academic journals. Won the second prizes of National Natural Science Award twice and the first prizes of Shanghai Natural Science Award twice, respectively.

Publications

1. Zhang, Xiaonan; Tan, Yun; Ling, Yun; Lu, Gang; Liu, Feng; Yi, Zhigang; Jia, Xiaofang; Wu, Min; Shi, Bisheng; Xu, Shuibao; Chen, Jun; Wang, Wei; Chen, Bing; Jiang, Lu; Yu, Shuting; Lu, Jin g; Wang, Jinzeng; Xu, Mingzhu; Yuan, Zhenghong; Zhang, Qin; Zhang, Xinxin; Zhao, Guoping; Wang, Shengyue*; Chen, Saijuan; Lu, Hongzhou; Viral and host factors related to the clinical outcome of COVID-19, Nature, 2020 Jul;583(7816):437-440. doi: 10.1038/s41586-020-2355-0

2. Benshang Li; Hui Li; Yun Bai; Renate Kirschner-Schwabe; Jun J Yang; Yao Chen; Gang Lu; Ga nnie Tzoneva; Xiaotu Ma; Tongmin Wu; Wenjing Li; Haisong Lu; Lixia Ding; Huanhuan Liang; Xiaohang Huang; Minjun Yang; Lei Jin; Hui Kang; Shuting Chen; Alicia Du; Shuhong Shen; Jianping Ding; Hong zhuan Chen; Jing Chen; Arend von Stackelberg; Longjun Gu; Jinghui Zhang; Adolfo Ferrando; Jingyan Tang; Shengyue Wang*; Bin-Bing S Zhou; Negative feedback-defective PRPS1 mutants resistance in relapsed childhood ALL, Nature Medicine, 2015 Jun;21(6):563-71. doi: 10.1038/nm.3840.

3. Zheng, Huajun; Zhang, Wenbao; Zhang, Liang; Zhang, Zhuangzhi; Li, Jun; Lu, Gang; Zhu, Yon gqiang; Wang, Yuezhu; Huang, Yin; Liu, Jing; Kang, Hui; Chen, Jie; Wang, Lijun; Chen, Aojun; Yu, Shuting; Gao, Zhengchao; Jin, Lei; Gu, Wenyi; Wang, Zhiqin; Zhao, Li; Shi, Baoxin; Wen, Hao; Lin, Renyong; Jones, Malcolm K; Brejova, Brona; Vinar, Tomas; Zhao, Guoping; McManus, Donald P; Chen, Zhu; Zhou, Yan; Wang, Shengyue*; The genome of the hydatid tapeworm Echinococcus granulosus, Nature Genetics, 2013, 45(10): 1168-1175 doi: 10.1038/ng.2757. (通讯作者)

4. Yan Zhou; Huajun Zheng; Yangyi Chen; Lei Zhang; Kai Wang; Jing Guo; Zhen Huang; Bo Zhang; Wei Huang; Ke Jin; Tonghai Dou; Masami Hasegawa; Li Wang; Yuan Zhang; Jie Zhou; Lin Tao; Zhiwei C ao; Yixue Li; Tomas Vinar; Brona Brejova; Dan Brown; Ming Li; David J. Miller; David Blair; Yang Zhong; Zhu Chen; Feng Liu; Wei Hu; Zhi-Qin Wang; Qin-Hua Zhang; Huai-Dong Song; Saijuan Chen; Xue nian Xu; Bin Xu; Chuan Ju; Yucheng Huang; Paul J. Brindley; Donald P. McManus; Zheng Feng; Ze-Gua ng Han; Gang Lu; Shuangxi Ren; Yuezhu Wang; Wenyi Gu; Hui Kang; Jie Chen; Xiaoyun Chen; Shuting Chen; Lijun Wang; Jie Yan; Biyun Wang; Xinyan Lv; Lei Jin; Bofei Wang; Shiyin Pu; Xianglin Zhang; Wei Zhang; Qiuping Hu; Genfeng Zhu; Jun Wang; Jun Yu; Jian Wan; Huanming Yang; Zemin Ning; Matthew Beriman; Chia-Lin Wei; Yijun Ruan; Guoping Zhao; Shengyue Wang*; The Schistosoma japonicumgeno me reveals features of host-parasite interplay, Nature, 2009 Jul 16; 460 (7253):345-51. doi: 10.1038/nature08140

5. The Chinese SARS Molecular Epidemiology Consortium#；Molecular evolution of the SARS coronavirus during the course of the SARS epidemic in China. Science 2004 Mar 12;303(5664):1666-9. doi: 10.1126/science.1092002

6. Watanabe H, Fujiyama A, Hattori M, Taylor TD, Toyoda A, Kuroki Y, Noguchi H, BenKahla A, Lehrach H, Sudbrak R, Kube M, Taenzer S, Galgoczy P, Platzer M, Scharfe M, Nordsiek G, Blocker H, Hellmann I, Khaitovich P, Paabo S, Reinhardt R, Zheng HJ, Zhang XL, Zhu GF, Wang BF, Fu G, Ren SX, Zhao GP, Chen Z, Lee YS, Cheong JE, Choi SH, Wu KM, Liu TT, Hsiao KJ, Tsai SF, Kim CG, OOta S, Kitano T, Kohara Y, Saitou N, Park HS, Wang SY, Yaspo ML, Sakaki Y. DNA sequence and comparative analysis of chimpanzee chromosome 22. Nature 2004 May 27；429(6990):382-8. doi: 10.1038/nature02564

7. Shuang-Xi Ren, Gang Fu, Xiu-Gao Jiang, Rong Zeng, You-Gang Miao, Hai Xu, Yi-Xuan Zhang, Hui Xiong, Gang Lu, Ling-Feng Lu, Hong-Quan Jiang, Jia Jia, Yue-Feng Tu, Ju-Xing Jiang, Wen-Yi Gu, Yue-Qing Zhang, Zhen Cai, Hai-Hui Sheng, Hai-Feng Yin, Yi Zhang, Gen-Feng Zhu, Ma Wan, Hong-Lei Huang, Zhen Qian, Sheng-Yue Wang, Wei Ma, Zhi-Jian Yao, Yan Shen, Bo-Qin Qiang, Qi-Chang Xia, Xiao-Kui Guo, Antoine Danchin, Isabelle Saint Girons, Ronald L Somerville, Yu-Mei Wen, Man-Hua Shi, Zhu Chen, Jian-Guo Xu, Guo-Ping Zhao Unique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing. Nature 2003 Apr 24;422(6934):888-93.doi: 10.1038/nature01597

8. Wei Hu, Qing Yan, Da-Kang Shen, Feng Liu, Zhi-Dong Zhu, Huai-Dong Song, Xiang-Ru Xu, Zhao-Jun Wang, Yi-Ping Rong, Ling-Chun Zeng, Jian Wu, Xin Zhang, Ju-Jun Wang, Xue-Nian Xu, Sheng-Yue Wang, Gang Fu, Xiang-Lin Zhang, Zhi-Qin Wang, Paul J Brindley, Donald P McManus, Chun-Liang Xue, Zheng Feng, Zhu Chen, Ze-Guang Han. Evolutionary and biomedical implications of a Schistosoma japonicum complementary DNA resource. Nature Genetics. 2003 Oct;35(2):139-47. doi: 10.1038/ng1236

9. Qi Feng, Yujun Zhang, Pei Hao, Shengyue Wang#, Gang Fu, Yucheng Huang, Ying Li, Jingjie Zhu, Yilei Liu, Xin Hu, Peixin Jia, Yu Zhang, Qiang Zhao, Kai Ying, Shuliang Yu, Yesheng Tang, Qijun Weng, Lei Zhang, Ying Lu, Jie Mu, Yiqi Lu, Lei S Zhang, Zhen Yu, Danlin Fan, Xiaohui Liu, Tingting Lu, Can Li, Yongrui Wu, Tongguo Sun, Haiyan Lei, Tao Li, Hao Hu, Jianping Guan, Mei Wu, Runquan Zhang, Bo Zhou, Zehua Chen, Ling Chen, Zhaoqing Jin, Rong Wang, Haifeng Yin, Zhen Cai, Shuangxi Ren, Gang Lv, Wenyi Gu, Genfeng Zhu, Yuefeng Tu, Jia Jia, Yi Zhang, Jie Chen, Hui Kang, Xiaoyun Chen, Chunyan Shao, Yun Sun, Qiuping Hu, Xianglin Zhang, Wei Zhang, Lijun Wang, Chunwei Ding, Haihui Sheng, Jingli Gu, Shuting Chen, Lin Ni, Fenghua Zhu, Wei Chen, Lefu Lan, Ying Lai, Zhukuan Cheng, Minghong Gu, Jiming Jiang, Jiayang Li, Guofan Hong, Yongbiao Xue, Bin Han. Sequence and analysis of rice chromosome 4. Nature 2002 Nov 21;420(6913):316-20 DOI: 10.1038/nature01183

10. Wang Sheng-Yue#, Cruts, M., Del-Favero, J., Zhang, Y., Tissir F., Potier, M.C., Patterson, D., Nizetic, D., Bosch, A., Chen, H.M. Bennett, L., Estivill, X., Kessling, A., Antonarakis, S.E., Van Broeckhoven, C. A high-resolution physical mapping of the human chromosome 21 short arm using yeast artificial chromosomes. Genome Res. 1999 Nov;9 (11):1059-73