Biography

• Executive member of Chinese Hepatology Society, former Chairman of Shanghai Medical Virology Society. Research on hepatitis B virus and SARS-CoV-2, especially viral mutations and its related pathogenesis.

Publications

1. Xinxin ZHANG, Wenhong ZHANG, Saijuan CHEN, Shanghai’s life-saving efforts against the current omicron wave of the COVID-19 pandemic. Lancet 2022 May 28;399(10340):2011-2012.

2. Xiaoqi Yu, Dong Wei, Wenxin Xu, Chuanmiao Liu, Wentian Guo, Xinxin Li, Wei Tan, Leshan Liu, Xinxin Zhang*, Jieming Qu*, Zhitao Yang*, Erzhen Chen*. Neutralizing activity of BBIBP-CorV vaccine-elicited sera against Beta, Delta and other SARS-CoV-2 variants of concern. Nat Commun. 2022 Apr 4;13(1):1788.

3. Dong Wei, Yingying Chen, Xiaoqi Yu, Yang-dian Lai, Wenxin Xu, Ping Ji, Zhitao Yang, Erzhen Chen, Xinxin Zhang*, Ying Wang*. Comparable antigen-specific T cell responses in vaccinees with diverse humoral immune responses after primary and booster BBIBP-CorV vaccination. Emerging Microbes & Infections 2022 on line.

4. Xiaoqi Yu, Dong Wei, Wenxin Xu, Yulong Li, Xinxin Li, Xinxin Zhang*, Jieming Qu*, Zhitao Yang*, Erzhen Chen*. Reduced sensitivity of SARS-CoV-2 Omicron variant to antibody neutralization elicited by booster vaccination. Cell Discovery 2022,8:4.

5. Cesheng Li, Ding Yu, Xiao Wu, Hong Liang, Zhijun Zhou, Yong Xie, Taojing Li, Junzheng Wu, Fengping Lu, Lu Feng, Min Mao, Lianzhen Lin, Huanhuan Guo, Shenglan Yue, Feifei Wang, Yan Peng, Yong Hu, Zejun Wang, Jianhong Yu, Yong Zhang, Jia Lu, Haoran Ning, Huichuan Yang, Daoxing Fu, Yanlin He, Dongbo Zhou, Tao Du, Kai Duan, Demei Dong, Kun Deng, Xia Zou, Ya Zhang, Rong Zhou, Yang Gao, Xinxin Zhang*, Xiaoming Yang*. Twelve-month specific IgG response to SARS-CoV-2 receptor-binding domain among COVID-19 convalescent plasma donors in Wuhan. Nat Commun. 2021,12:4144.

6. Mingjie Wang, Li Chen, MinHui Dong, Jing Li, Beidi Zhu, Zhitao Yang, Qiming Gong, Yue Han, Demin Yu, Donghua Zhang, Fabien Zoulim, Jiming Zhang & Xinxin Zhang*. Viral quasispecies quantitative analysis: a novel approach for appraising the immune tolerant phase of chronic hepatitis B virus infection. Emerging Microbes & Infections, 2021,10:842-851.

7. Effectiveness of convalescent plasma therapy in severe COVID-19 patients. Kai Duana, Bende Liuc, Cesheng Lid, Huajun Zhange, Ting Yuf, Jieming Qug, Min Zhoug, Li Chen, Shengli Meng, Yong Hu, Cheng Peng, Mingchao Yuan, Jinyan Huan, Zejun Wang, Jianhong Yu, Xiaoxiao Gao, Dan Wang, Xiaoqi Yu, Li Li, Jiayou Zhang, Xiao Wu, Bei Li, Yanping Xu, Wei Chen, Yan Peng, Yeqin Hu, Lianzhen Lin, Xuefei Liu, Shihe Huang, Zhijun Zhou, Lianghao Zhang, Yue Wang, Zhi Zhang, Kun Deng, Zhiwu Xia, Qin Gong, Wei Zhang, Xiaobei Zheng, Ying Liu, Huichuan Yang, Dongbo Zhou,Ding Yu, Jifeng Hou, Zhengli Shi, Saijuan Chen, Zhu Chen*, Xinxin Zhang*, Xiaoming Yang*. PNAS 2020 Apr 28;117(17):9490-9496.

8. Nanshan Chen, Min Zhou, Xuan Dong, Jieming Qu, Fengyun Gong, Yang Han, Yang Qiu, Jingli Wang, Ying Liu, Yuan Wei, Jia’an Xia, Ting Yu, Xinxin Zhang*, Li Zhang*. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet, February 15, 2020, Vol 395:507-513.

9. Feng Liu, Li Chen, DeMin Yu, Lin Deng, Rong Chen, Yin Jiang, Liang Chen, Su-Yuan Huang, Qi-Ming Gong, XinXin Zhang*. Evolution Patterns of Hepatitis B Virus Quasispecies under Different Selective Pressures: Correlation with Antiviral Efficacy. Gut 2011,60:1269-1277.

10. Li Chen, Qian Zhang, Demin Yu, Mobin Wan, Xinxin Zhang*. Early changes of hepatitis B virus quasispecies during lamivudine treatment and its prediction for antiviral efficacy. J Hepatology 2009,50:895-905.