Biography

• Qing Xie is currently the director of Department of Infectious Disease in Ruijin Hospital, Shanghai Jiaotong University School of Medicine; Director of Severe Viral hepatitis Clinical Center in Shanghai Jiaotong University School of Medicine and Ph.D. Mentor，as well as a director of Shanghai Clinical Quality Control Center of Infectious Diseases. Also Prof.Xie is the former Vice director of Chinese Medical Association of Infectious Diseases Branch, Vice president of the Chinese Medical Doctor Association branch of infection，the Former director of infectious diseases branch of Shanghai Medical Association. She is also the associate editor of Chinese Journal of Infectious Diseases. Professor Xie currently focuses on the basic and clinical research of infectious disease including clinical management of liver diseases,pathogenesis of liver injury and regeneration. Prof. Xie has conducted many multicenter clinical trails as principal investigator in the filed of liver diseases, and has built long term follow up clinical database and Bio-bank. As a principal investigators she has more than 30 grants from China National Natural Science committee and Shanghai Municipal government and National key projects from China. She has published over 300 papers in peer-reviewed journals including BMJ,J Heaptology, Hepatology,AJG,Clinic Infect Dis and J infect Dis. Also she is the associate editor of two books: Hepatitis C-Clinical diagnosis and treatment, Drug-Induced and Toxic Liver Disease.

Publications(#:corresponding author or first author)

1. Wei Tang,Zhujun Cao, Mingfeng Han, Zhengyan Wang, Junwen Chen, Wenjin Sun, Yaojie Wu,   Wei Xiao, Shengyong Liu, Erzhen Chen, Wei Chen, Xiongbiao Wang, Jiuyong Yang, Jun Lin, Qingxia Zhao, Youqin Yan, Zhibin Xie, Dan Li, Yaofeng Yang, Leshan Liu, Jieming Qu, Guang Ning, Guochao Shi, Qing Xie#.Hydroxychloroquine in patients with mainly mild to moderate coronavirus disease 2019: open label, randomised controlled trial.BMJ 2020;369:m1849 | doi: 10.1136/bmj.m1849

2. Zhujun Cao, Yuhan Liu, Minghao Cai,Yumin Xu,Xiaogang Xiang,Gangde Zhao, Wei Cai, Hui   Wang, Weijing Wang,and Qing Xie#.The Use of NACSELD and EASL-CLIF Classification Systems of ACLF in the Prediction of Prognosis in Hospitalized Patients With Cirrhosis.Am J Gastroenterol. 2020 Dec;115(12):2026-2035

3. Lei Fan,Rongtao Lai,Ningning Ma,Yunxia Dong,Yu Li,Qian Wu,Junwen Qiao,Henglei Lu,Likun Gong,Zhouteng Tao,Jing Chen,Qing Xie#,Jin Ren.miR-552-3p modulates transcriptional activities of FXR and LXR to ameliorate hepatic glycolipid metabolism disorder.Journal of Hepatology，2021,74,(1) :8-19

4. Xiaogang Xiang, Dechun Feng, Seonghwan Hwang, Tianyi Ren, Xiaolin Wang, Eszter Trojnar, Csaba Matyas, Ruidong Mo, Dabao Shang, Yong He, Wonhyo Seo,  Vijay H. Shah, Pal Pacher, Qing Xie#, Bin Gao.Interleukin-22 ameliorates acute-on-chronic liver failure by reprogramming of impaired regeneration pathways. Journal of Hepatology 2020 vol. 72：736–74

5. Lai R, Xiang X, Mo R, Bao R, Wang P, Guo S, Zhao G, Gui H, Wang H, Bao S, Xie Q#. Protective effect of Th22 cells and intrahepatic IL-22 in drug induced hepatocellular injury. J Hepatol. 2015 Jul;63(1):148-55

6. Kwan R, Chen L, Looi K, Tao GZ, Weerasinghe SV, Snider NT, Anne Conti M, Adelstein RS, Xie Q#, Omary MB. PKC412 normalizes mutation-related keratin filament disruption and hepatic injury in mice by promoting keratin-myosin binding. Hepatology. 2015 Dec;62(6):1858-69

7. Toy M, Salomon JA, Jiang H, Gui H, Wang H, Wang J, Richardus JH, Xie Q#. Population health impact and cost-effectiveness of monitoring inactive chronic hepatitis B and treating eligible patients in Shanghai, China. Hepatology. 2014 Jul;60(1):46-55

8. Xie Q#, Khaoustov VI, Chung CC, Sohn J, Krishnan B, Lewis DE, Yoffe B. Effect of tauroursodeoxycholic acid on endoplasmic reticulum stress-induced caspase-12 activation. Hepatology. 2002 Sep;36(3):592-601

9. Fan R, Zhou B, Xu M, Tan D, Niu J, Wang H, Ren H, Chen X, Wang M, Ning Q, Shi G, Sheng J, Tang H, Bai X, Liu S, Lu F, Peng J, Sun J, Xie Q#, Hou J; Chronic Hepatitis B Study Consortium. Association Between Negative Results From Tests for HBV DNA and RNA and Durability of Response After Discontinuation of Nucles(t)ide Analogue Therapy. Clin Gastroenterol Hepatol. 2020 Mar;18(3):719-727

10. Jie Lu,Yan Huang,Peiyun Wang,Qing Li,Ziqiang Li,Jiayuan Jiang,Qing Guo,Honglian Gui,Qing Xie#.Dynamics of HEV Antibodies and Development of a Multi-factorial Model to Improve the Diagnosis of Current HEV Infection in Resource-limited Settings.J Clin Microbiol，2021 ,59(2): e02321-20