Biography

• Guang Ning is Academician of Chinese Academy of Engineering, tenure Professor of Ruijin Hospital. He received the National Science Fund for Distinguished Young Scholars and “Changjiang” Professor. He is currently president of Ruijin Hospital, Shanghai Jiaotong University School of Medicine, and director of the Shanghai Institute of Endocrine & Metabolic Diseases. He is former Chair of the Chinese Society for Clinical Endocrinologists (2013-2019), president of the Chinese Endocrine Society (2008-2012). He is Editor-in-Chief of the Chinese Journal of Endocrinology and Metabolism, Journal of Diabetes.

• He has been working in the field of endocrine & metabolic diseases for decades and has published over 500 research papers in peer-reviewed journals, including Science, JAMA, Nat Cell Biol, J Am Coll Cardiol, and Nat Med. He is the 4-time winner of the National Science and Technical Progress Award (2nd class) in 2008, 2010, 2012 and 2017 (ranking first place twice). He is the winner of Shulan Medicine Award (2017), Chinese Physician Award (2014), Wu Jieping Medicine Innovation Prize, Bethune Good Doctor, International Endocrinology Award from the American Association of Clinical Endocrinologists, Lifetime Achievement Award from the Israel Diabetes Association and Ministry of Health, Yutaka Seino Outstanding Leadership Award from the Asian Association for the Study of Diabetes, and Honorary Fellowship Award from the American College of Cardiology.

Publications

1. Zhang Y, Wang Y, Ning G, He P, Wang W. Protecting older people: a high priority during the COVID-19 pandemic. Lancet. 2022 Sep 3;400(10354):729-730.

2. Li L, Huang P, Sun X, Wang S, Xu M, Liu S, Feng Z, Zhang Q, Wang X, Zheng X, Dai M, Bi Y, Ning G, Cao Y, Wang W.. The ChinaMAP reference panel for the accurate genotype imputation in Chinese populations. Cell Res. 2021 Dec;31(12):1308-1310.

3. Zheng R, Xu Y, Niu J, Wu S, Li M, Lu J, Wang S, Xu Y, Wang W, Bi Y, Ning G. Type 2 diabetes RCTs in mainland China: insights from a systematic review. Lancet Diabetes Endocrinol. 2021 Feb;9(2):64-66.

4. Cao Y, Li L, Xu M, Feng Z, Sun X, Lu J, Xu Y, Du P, Wang T, Hu R, Ye Z, Shi L, Tang X, Yan L, Gao Z, Chen G, Zhang Y, Chen L, Ning G, Bi Y, Wang W; ChinaMAP Consortium. The ChinaMAP analytics of deep whole genome sequences in 10,588 individuals. Cell Res. 2020 Sep;30(9):717-731.

5. Wang T, Lu J, Shi L, Chen G, Xu M, Xu Y, Su Q, Mu Y, Chen L, Hu R, Tang X, Yu X, Li M, Zhao Z, Chen Y, Yan L, Qin G, Wan Q, Dai M, Zhang D, Gao Z, Wang G, Shen F, Luo Z, Qin Y, Chen L, Huo Y, Li Q, Ye Z, Zhang Y, Liu C, Wang Y, Wu S, Yang T, Deng H, Zhao J, Lai S, Bi Y, DeFronzo RA, Wang W, Ning G; China Cardiometabolic Disease and Cancer Cohort Study Group. Association of insulin resistance and β-cell dysfunction with incident diabetes among adults in China: a nationwide, population-based, prospective cohort study. Lancet Diabetes Endocrinol. 2020 Feb;8(2):115-124.

6. Cao Y, Li L, Feng Z, Wan S, Huang P, Sun X, Wen F, Huang X, Ning G, Wang W. Comparative genetic analysis of the novel coronavirus (2019-nCoV/SARS-CoV-2) receptor ACE2 in different populations. Cell Discov. 2020 Feb 24;6:11.

7. Wang T, Lu J, Su Q, Chen Y, Bi Y, Mu Y, Chen L, Hu R, Tang X, Yu X, Li M, Xu M, Xu Y, Zhao Z, Yan L, Qin G, Wan Q, Chen G, Dai M, Zhang D, Gao Z, Wang G, Shen F, Luo Z, Qin Y, Chen L, Huo Y, Li Q, Ye Z, Zhang Y, Liu C, Wang Y, Wu S, Yang T, Deng H, Li D, Lai S, Bloomgarden ZT, Shi L, Ning G, Zhao J, Wang W; 4C Study Group. Ideal Cardiovascular Health Metrics and Major Cardiovascular Events in Patients With Prediabetes and Diabetes. JAMA Cardiol. 2019 Sep 1;4(9):874-883.

8. Liu R, Hong J, Xu X, Feng Q, Zhang D, Gu Y, Shi J, Zhao S, Liu W, Wang X, Xia H, Liu Z, Cui B, Liang P, Xi L, Jin J, Ying X, Wang X, Zhao X, Li W, Jia H, Lan Z, Li F, Wang R, Sun Y, Yang M, Shen Y, Jie Z, Li J, Chen X, Zhong H, Xie H, Zhang Y, Gu W, Deng X, Shen B, Xu X, Yang H, Xu G, Bi Y, Lai S, Wang J, Qi L, Madsen L, Wang J, Ning G, Kristiansen K, Wang W. Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention. Nat Med. 2017 Jul;23(7):859-868.

9. Cao Y, He M, Gao Z, Peng Y, Li Y, Li L, Zhou W, Li X, Zhong X, Lei Y, Su T, Wang H, Jiang Y, Yang L, Wei W, Yang X, Jiang X, Liu L, He J, Ye J, Wei Q, Li Y, Wang W, Wang J, Ning G. Activating hotspot L205R mutation in PRKACA and adrenal Cushing's syndrome. Science. 2014 May 23;344(6186):913-7.

10. Zhang Z, Zhang H, Li B, Meng X, Wang J, Zhang Y, Yao S, Ma Q, Jin L, Yang J, Wang W, Ning G. Berberine activates thermogenesis in white and brown adipose tissue. Nat Commun. 2014 Nov 25;5:5493.

11. Jiang X, Cao Y, Li F, Su Y, Li Y, Peng Y, Cheng Y, Zhang C, Wang W, Ning G. Targeting β-catenin signaling for therapeutic intervention in MEN1-deficient pancreatic neuroendocrine tumours. Nat Commun. 2014 Dec 17;5:5809

12. Zhu W, Ye L, Shen L, Jiao Q, Huang F, Han R, Zhang X, Wang S, Wang W, Ning G. A prospective, randomized trial of intravenous glucocorticoids therapy with different protocols for patients with graves' ophthalmopathy. J Clin Endocrinol Metab. 2014 Jun;99(6):1999-2007.

13. Wang J, Liu R, Wang F, Hong J, Li X, Chen M, Ke Y, Zhang X, Ma Q, Wang R, Shi J, Cui B, Gu W, Zhang Y, Zhang Z, Wang W, Xia X, Liu M, Ning G. Ablation of LGR4 promotes energy expenditure by driving white-to-brown fat switch. Nat Cell Biol. 2013 Dec;15(12):1455-63.

14. Xu Y, Wang L, He J, Bi Y, Li M, Wang T, Wang L, Jiang Y, Dai M, Lu J, Xu M, Li Y, Hu N, Li J, Mi S, Chen CS, Li G, Mu Y, Zhao J, Kong L, Chen J, Lai S, Wang W, Zhao W, Ning G; 2010 China Noncommunicable Disease Surveillance Group. Prevalence and control of diabetes in Chinese adults. JAMA. 2013 Sep 4;310(9):948-59.

15. Hong J, Zhang Y, Lai S, Lv A, Su Q, Dong Y, Zhou Z, Tang W, Zhao J, Cui L, Zou D, Wang D, Li H, Liu C, Wu G, Shen J, Zhu D, Wang W, Shen W, Ning G; SPREAD-DIMCAD Investigators. Effects of metformin versus glipizide on cardiovascular outcomes in patients with type 2 diabetes and coronary artery disease. Diabetes Care. 2013 May;36(5):1304-11.

16. Cao Y, Xue Y, Xue L, Jiang X, Wang X, Zhang Z, Yang J, Lu J, Zhang C, Wang W, Ning G. Hepatic menin recruits SIRT1 to control liver steatosis through histone deacetylation. J Hepatol. 2013 Dec;59(6):1299-306.

17. Gu W, Hu J, Wang W, Li L, Tang W, Sun S, Cui W, Ye L, Zhang Y, Hong J, Zhu D, Ning G. Diabetic ketoacidosis at diagnosis influences complete remission after treatment with hematopoietic stem cell transplantation in adolescents with type 1 diabetes. Diabetes Care. 2012 Jul;35(7):1413-9.

18. Wang J, Li X, Ke Y, Lu Y, Wang F, Fan N, Sun H, Zhang H, Liu R, Yang J, Ye L, Liu M, Ning G. GPR48 increases mineralocorticoid receptor gene expression. J Am Soc Nephrol. 2012 Feb;23(2):281-93.