Biography

• Prof. Chen is focused on molecular and systems biological studies of hematological diseases. Following the concepts of systems and integration and by developing the new generation techniques of genomics, transcriptomics, proteomics and metabolomics as well as big data platform for bioinformatics, he has launched Leukemia Genomics Anatomy Project (LGAP) and Leukemia Integrative Chemical Genomics Project (LICG). Focused on the genomic study of leukemia, he tries to give a panoramic view of the molecular mechanisms of development and targeted treatment of leukemia by unraveling systematic leukemogenesis, key signal pathways and regulatory nodes, molecular regulatory networks, and to reveal the rules in the occurrence, development and outcome of leukemia. He also aims to detect a group of new molecular markers and drug targets, and to develop several novel drugs or combination of drugs for targeted therapy. In the meantime, he will strive to explore the theoretical and practical systems of precise medicine of leukemia, and develop a strategic system for the prevention, diagnosis, treatment and control of leukemia.

Publications

1. Chen Z, Chen SJ. Poisoning the Devil. Cell. 2017;168(4):556-560.

2. Zhang XW, Yan XJ, Yang FF, Zhou ZR, Wu ZY, Sun HB, Liang WX, Song AX, Huang QH, Zhou GB, Tong JH, Zhang Y, Wu JH, Hu HY, de Thé H, Chen SJ, Chen Z. Arsenic trioxide controls the fate of the PML-RAR oncoprotein by directly binding PML. Science 2010; 328: 240-243.

3. Jiang L, Gu ZH, Yan ZX, Zhao X, Xie YY, Zhang ZG, Pan CM, Hu CP, Dong Y, Huang JY, Wang L, Shen Y, Meng GY, Zhou JF, Hu JD, Wang JF, Liu YH, Yang LH, Zhang F, Wang JM, Wang Z, Peng ZH, Chen FY, Sun ZM, Ding H, Shi JM, Hou J, Yan JS, Shi JY, Xu L, Li Y, Lu J, Zheng Z, Xue W, Zhao WL, Chen Z, Chen SJ. Exome sequencing identifies somatic mutations of DDX3X in natural killer/T-cell lymphoma. Nature Genetics 2015; 47:1061-1066.

4. Yan XJ, Xu J, Gu ZH, Pan CM, Lu G, Shen Y, Shi JY, Zhu YM, Tang L, Zhang XW, Liang WX, Mi JQ, Song HD, Li KQ, Chen Z, Chen SJ. Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia. Nature Genetics 2011; 43:309-315.

5. Tan Y, Wang XL, Song H, Zhang Y, Zhang RS, Li SF, Jin W, Chen SJ, Fang H, Chen Z, Wang KK. A PML/RARα direct target atlas redefines transcriptional deregulation in acute promyelocytic leukemia. Blood. 2021;137(11):1503-1516.

6. Sun XJ, Chen SJ, Chen Z. Treating leukemia: differentiation therapy for mIDH2 AML. Cell Res. 2019;29:427-428.

7. Lin XJ, Qiao N, Shen Y, Fang H, Xue Q, Cui BW, Chen L, Zhu HM, Zhang SJ, Chen Y, Jiang L, Wang SY, Li JM, Wang BS, Chen B, Chen Z, Chen SJ. Integration of Genomic and Transcriptomic Markers Improves the Prognosis Prediction of Acute Promyelocytic Leukemia. Clin Cancer Res.2021. doi: 10.1158

8. Wang DW, Shao XH, Wang Q, Pan XH, Dai YJ, Yao SX, Yin T, Wang ZG, Zhu J, Xi XD, Chen Z, Chen SJ, Zhang GW. Activated factor X targeted stored in platelets as an effective gene therapy strategy for both hemophilia A and B. Clin Transl Med. 2021;11(3):e375.

9. Wang Q, Zhang L, Zhang GW, Mao JH, Xi XD, Jiang L, Lv G, Lu J, Shen Y, Chen Z, Zhu J, Chen SJ. Inherent hepatocytic heterogeneity determines expression and retention of edited F9 alleles post-AAV/CRISPR infusion. Proc Natl Acad Sci U S A.2021;118(42): e2110887118.

10. Chen L, Zhu HM, Li Y, Liu QF, Hu Y, Zhou JF, Jin J, Hu JD, Liu T, Wu DP, Chen JP, Lai YR, Wang JX, Li J, Li JY, Du X, Wang X, Yang MZ, Yan JS, Ouyang GF, Liu L, Hou M, Huang XJ, Yan XJ, Xu D, Li WM, Li DJ, Lou YJ, Wu ZJ, Niu T, Wang Y, Li XY, You JH, Zhao HJ, Chen Y, Shen Y, Chen QS, Chen Y, Li J, Wang BS, Zhao WL, Mi JQ, Wang KK, Hu J, Chen Z, Chen SJ, Li JM. Arsenic trioxide replacing or reducing chemotherapy in consolidation therapy for acute promyelocytic leukemia (APL2012 trial). Proc Natl Acad Sci U S A.2021;118(6):e2020382118.

11. Jiang L, Li XP, Dai YT, Chen B, Weng XQ, Xiong SM, Zhang M, Huang JY, Chen Z, Chen SJ. Multidimensional study of the heterogeneity of leukemia cells in t(8;21) acute myelogenous leukemia identifies the subtype with poor outcome. Proc Natl Acad Sci U S A.2020;117(33):20117-20126.

12. Wu SF, Xia L, Shi XD, Dai YJ, Zhang WN, Zhao JM, Zhang W, Weng XQ, Lu J, Le HY, Tao SC, Zhu J, Chen Z, Wang YY, Chen SJ. RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation. Proc Natl Acad Sci U S A.2020;117(25):14395-14404.

13. Duan K, Liu BD, Li CS, Zhang HJ, Yu T, Qu JM, Zhou M, Chen L, Meng SL, Hu Y, Peng C, Yuan MC, Huang JY, Wang ZJ, Yu JH, Gao XX, Wang D, Yu XQ, Li L, Zhang JY, Wu X, Li B, Xu YP, Chen W, Peng Y, Hu YQ, Lin LZ, Liu XF, Huang SH, Zhou ZJ, Zhang LH, Wang Y, Zhang Z, Deng K, Xia ZW, Gong Q, Zhang W, Zheng XB, Liu Y, Yang HC, Zhou DB, Yu D, Hou JF, Shi ZL, Chen SJ, Chen Z, Zhang XX, Yang XM. Effectiveness of convalescent plasma therapy in severe COVID-19 patients. ProcNatlAcadSci U S A. 2020;117(17):9490-9496.

14. Xu J, Chen LJ, Yang SS, Sun Y, Wu W, Liu YF, Xu J, Zhuang Y, Zhang W, Weng XQ, Wu J, Wang Y, Wang J, Yan H, Xu WB, Jiang H, Du J, Ding XY, Li B, Li JM, Fu WJ, Zhu J, Zhu L, Chen Z, Fan XF, Hou J, Li JY, Mi JQ, Chen SJ. Exploratory trial of a biepitopic CAR T-targeting B cell maturation antigen in relapsed/refractory multiple myeloma. Proc Natl Acad Sci U S A.2019;116:9543-9551.

15. Chen XJ, Zhang WN, Chen B, Xi WD, Lu Y, Huang JY, Wang YY, Long J, Wu SF, Zhang YX, Wang S, Li SX, Yin T, Lu M, Xi XD, Li JM, Wang KK, Chen Z, Chen SJ. Homoharringtonine deregulates MYC transcriptional expression by directly binding NF-κB repressing factor. Proc Natl Acad Sci U S A. 2019;116:2220-2225.