Biography

• Prof. QU Jieming specializes in pulmonary and critical care medicine. He is a senior expert in the epidemiology, microbiology, diagnosis and treatment of lower respiratory tract infection. He has been exploring the therapeutic effect and biological mechanism of mesenchymal stromal cells as well as the secreted extracellular microvesicles in severe pulmonary infection. He leverages CRISPR-Cas12, LAMP, mNGS, deep learning and other methods to develop novel approaches for rapid pathogen detection and antimicrobial resistance prediction. He is also interested in studying host-microbe interactions aiming to offer new insights into the intervention of pulmonary infection. He currently serves as Director of Scientific Committee of Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, President of Chinese Thoracic Society, and Deputy President of Chest Physicians Society of Chinese Medical Doctor Association. His research has been supported by National key research and development projects (1 project), National Natural Science Foundation of China (7 projects) and National Key Basic Research program (2 sub-projects) and has been awarded for National Science and Technology Progress Award (2nd prize, 2007) and Municipal Science and Technology Progress Award (1st prize, 2020; 2nd prize, 2006). He has more than 300 publications, with 134 of SCI included (Total impact factors: 985).

Publications

1. Qu J, Zhang J, Chen Y, Huang Y, Xie Y, Zhou M, Li Y, Shi D, Xu J, Wang Q, He B, Shen N, Cao B, She D, Shi Y, Su X, Zhou H, Fan H, Ye F, Zhang Q, Tian X, Lai G. Aetiology of severe community acquired pneumonia in adults identified by combined detection methods: a multi-centre prospective study in China. Emerg Microbes Infect. 2022;11(1):556-566.

2. Yu X, Wei D, Xu W, Li Y, Li X, Zhang X, Qu J, Yang Z, Chen E. Reduced sensitivity of SARS-CoV-2 Omicron variant to antibody neutralization elicited by booster vaccination. Cell Discov. 2022;8(1):4.

3. Yu X, Wei D, Xu W, Liu C, Guo W, Li X, Tan W, Liu L, Zhang X, Qu J, Yang Z, Chen E. Neutralizing activity of BBIBP-CorV vaccine-elicited sera against Beta, Delta and other SARS-CoV-2 variants of concern. Nat Commun. 2022;13(1):1788.

4. Liu X, Xu Y, Wu X, Liu Y, Wu Q, Wu J, Zhang H, Zhou M, Qu J. Soluble Immune-Related Proteins as New Candidate Serum Biomarkers for the Diagnosis and Progression of Lymphangioleiomyomatosis. Front Immunol. 2022;13:844914.

5. Poirier AC, Kuang D, Siedler BS, Borah K, Mehat JW, Liu J, Tai C, Wang X, van Vliet AHM, Ma W, Jenkins DR, Clark J, La Ragione RM, Qu J, McFadden J. Development of Loop-Mediated Isothermal Amplification Rapid Diagnostic Assays for the Detection of Klebsiella pneumoniae and Carbapenemase Genes in Clinical Samples. Front Mol Biosci. 2022;8:794961.

6. Zhu YG, Shi MM, Monsel A, Dai CX, Dong X, Shen H, Li SK, Chang J, Xu CL, Li P, Wang J, Shen MP, Ren CJ, Chen DC, Qu JM. Nebulized exosomes derived from allogenic adipose tissue mesenchymal stromal cells in patients with severe COVID-19: a pilot study. Stem Cell Res Ther. 2022;13(1):220.

7. Liu KX, Liu HX, Zhang J, Zhang N, Zhou YZ, Tao MM, Wang HW, Qu JM. Biogeography of the Respiratory Tract Microbiome in Patients With Malignant Tracheal Tumors. Front Oncol. 2021;11:758917.

8. Liu Y, Lu HW, Gu SY, Wang WW, Ge J, Jie ZJ, Jia JG, Gao ZT, Li J, Shi JY, Liang S, Cheng KB, Bai JW, Qu JM, Xu JF. Bronchoscopic airway clearance therapy for acute exacerbations of bronchiectasis. EBioMedicine. 2021;72:103587.

9. Li YN, Wang ZW, Li F, Zhou LH, Jiang YS, Yu Y, Ma HH, Zhu LP, Qu JM, Jia XM. Inhibition of myeloid-derived suppressor cell arginase-1 production enhances T-cell-based immunotherapy against Cryptococcus neoformans infection. Nat Commun. 2022;13(1):4074.

10. Mei H, Zha Z, Wang W, Xie Y, Huang Y, Li W, Wei D, Zhang X, Qu J, Liu J. Surfaceome CRISPR screen identifies OLFML3 as a rhinovirus-inducible IFN antagonist. Genome Biol. 2021;22(1):297.

11. Yu S, Di C, Chen S, Guo M, Yan J, Zhu Z, Liu L, Feng R, Xie Y, Zhang R, Chen J, Wang M, Wei D, Fang H, Yin T, Huang J, Chen S, Lu H, Zhu J, Qu J. Distinct immune signatures discriminate between asymptomatic and presymptomatic SARS-CoV-2pos subjects. Cell Res. 2021;31(11):1148-1162.

12. Liu T*, Dai J*, Yang Z, Yu X, Xu Y, Shi X, Wei D, Tang Z, Xu G, Xu W, Liu Y, Shi C, Ni Q, Yang C, Zhang X, Wang X, Chen E, Qu J. Inactivated SARS-CoV-2 vaccine does not influence the profile of prothrombotic antibody nor increase the risk of thrombosis in a prospective Chinese cohort. Sci Bull (Beijing). 2021;66(22):2312-2319.

13. Shi MM, Yang QY, Monsel A, Yan JY, Dai CX, Zhao JY, Shi GC, Zhou M, Zhu XM, Li SK, Li P, Wang J, Li M, Lei JG, Xu D, Zhu YG, Qu JM. Preclinical efficacy and clinical safety of clinical-grade nebulized allogenic adipose mesenchymal stromal cells-derived extracellular vesicles. J Extracell Vesicles. 2021;10(10):e12134.

14. Guo L, Song Y, Li N, Qin B, Hu B, Yi H, Huang J, Liu B, Yu L, Huang Y, Zhou M, Qu J. A New Prognostic Index PDPI for the Risk of Pneumonia Among Patients With Diabetes. Front Cell Infect Microbiol. 2021;11:723666.

15. Xu Y, Zhang J, Wang M, Liu M, Liu G, Qu H, Liu J, Deng Z, Sun J, Ou HY, Qu J. Mobilization of the nonconjugative virulence plasmid from hypervirulent Klebsiella pneumoniae. Genome Med. 2021;13(1):119.

16. Zhang M, Yu Q, Tang W, Wu Y, Lv J, Sun L, Shi G, Wu M, Qu J, Di C, Xia Z. Epithelial exosomal contactin-1 promotes monocyte-derived dendritic cell-dominant T-cell responses in asthma. J Allergy Clin Immunol. 2021;148(6):1545-1558.

17. Wang X, Zhao Y, Li D, Feng Y, Xie Y, Zhou Y, Zhou M, Wang Y, Qu J, Zuo W. Intrapulmonary distal airway stem cell transplantation repairs lung injury in chronic obstructive pulmonary disease. Cell Prolif. 2021;54(6):e13046.

18. Jiang Y, Li F, Li Y, Duan J, Di C, Zhu Y, Zhao J, Jia X, Qu J. CD69 mediates the protective role of adipose tissue-derived mesenchymal stem cells against Pseudomonas aeruginosa pulmonary infection. Clin Transl Med. 2021;11(11):e563.

19. Liu D, Zeng YY, Shi MM, Qu JM. Glucocorticoids Elevate Pseudomonas aeruginosa Binding to Airway Epithelium by Upregulating Syndecan-1 Expression. Front Microbiol. 2021;12:725483.

20. Zhao B, Liu M, Liu P, Peng Y, Huang J, Li M, Wang Y, Xu L, Sun S, Qi X, Ling Y, Li J, Zhang W, Mao E, Qu J. High Dose Intravenous Vitamin C for Preventing The Disease Aggravation of Moderate COVID-19 Pneumonia. A Retrospective Propensity Matched Before-After Study. Front Pharmacol. 2021;12:638556.

21. Huang J, Xie Y, Yuan D, Guo L, Qu J, Zhou M. Identification of distinct metabolic characteristics of pneumonia in type 2 diabetes mellitus. Clin Transl Med. 2021;11(2):e303.

22. Wang Y, Liu D, Lin H, Chen D, Sun J, Xie Y, Wang X, Ma P, Nie Y, Mei H, Zhao B, Huang X, Jiang G, Jiang X, Qu J, Zhao J, Liu J. Development of a Broadly Applicable Cas12a-Linked Beam Unlocking Reaction for Sensitive and Specific Detection of Respiratory Pathogens Including SARS-CoV-2. ACS Chem Biol. 2021;16(3):491-500.

23. Li LL, Zhu YG, Jia XM, Liu D, Qu JM. Adipose-Derived Mesenchymal Stem Cells Ameliorating Pseudomonas aeruginosa-induced Acute Lung Infection via Inhibition of NLRC4 Inflammasome. Front Cell Infect Microbiol. 2021;10:581535.

24. Shi MM, Zhu YG, Yan JY, Rouby JJ, Summah H, Monsel A, Qu JM. Role of miR-466 in mesenchymal stromal cell derived extracellular vesicles treating inoculation pneumonia caused by multidrug-resistant Pseudomonas aeruginosa. Clin Transl Med. 2021;11(1):e287.

25. Liu J, Zhang S, Dong X, Li Z, Xu Q, Feng H, Cai J, Huang S, Guo J, Zhang L, Chen Y, Zhu W, Du H, Liu Y, Wang T, Chen L, Wen Z, Annane D, Qu J, Chen D. Corticosteroid treatment in severe COVID-19 patients with acute respiratory distress syndrome. J Clin Invest. 2020;130(12):6417-6428.

26. Zuo YH, Wang WQ, Chen QJ, Liu B, Zhang FY, Jin XY, Hang JQ, Li HY, Bao ZY, Jie ZJ, Wang GF, Gao XW, Sun H, Xu JF, Zhang J, Qu JM. Candida in Lower Respiratory Tract Increases the Frequency of Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Retrospective Case-Control Study. Front Cell Infect Microbiol. 2020;10:538005.

27. Zhang YJ, Yang WJ, Liu D, Cao YQ, Zheng YY, Han YC, Jin RS, Han Y, Wang XY, Pan AS, Dai JY, Sun QF, Zhao FQ, Yang QY, Zhang JH, Liu SJ, Da Q, Guo W, Li CQ, Zhang WT, Wu H, Chen XS, Ji AQ, Xiang J, Chen K, Feng XJ, Zhang XF, Cao QQ, Qin L, Li J, Zhou M, Lu Y, Wang CF, Yan FH, Li HC, Qu JM. COVID-19 and early-stage lung cancer both featuring ground-glass opacities: a propensity score-matched study. Transl Lung Cancer Res. 2020;9(4):1516-1527.

28. Liu J, Zhang S, Wu Z, Shang Y, Dong X, Li G, Zhang L, Chen Y, Ye X, Du H, Liu Y, Wang T, Huang S, Chen L, Wen Z, Qu J, Chen D. Clinical outcomes of COVID-19 in Wuhan, China: a large cohort study. Ann Intensive Care. 2020;10(1):99.

29. Liu Z, Li Y, Tian X, Liu Q, Li E, Gu X, Liu M, Xu J, He Z, Huang Y, Xu S, Lai G, Chen Y, Zhang X, Zhang T, Xu J, Zhu L, Qu J, Cao B. Airway-invasion-associated pulmonary computed tomography presentations characteristic of invasive pulmonary Aspergillosis in non-immunocompromised adults: a National Multicenter Retrospective Survey in China. Respir Res. 2020;21(1):173.

30. Qin L, Yang Y, Cao Q, Cheng Z, Wang X, Sun Q, Yan F, Qu J, Yang W. A predictive model and scoring system combining clinical and CT characteristics for the diagnosis of COVID-19. Eur Radiol. 2020;30(12):6797-6807.

31. Mao B, Liu Y, Chai YH, Jin XY, Lu HW, Yang JW, Gao XW, Song XL, Bao H, Wang A, Gu WC, Zhao L, Pan JP, Li F, Zhang TF, Qian YC, Du CL, Ding W, Tu CL, Chu DJ, Li C, Ye L, Luo Y, Zheng CX, Yu RH, Qiu ZM, Cao HF, Ren JW, Zhao JY, Wang CH, Lu HZ, Li J, Hu Y, Liang S, Jie ZJ, Qu JM, Xu JF. Assessing risk factors for SARS-CoV-2 infection in patients presenting with symptoms in Shanghai, China: a multicentre, observational cohort study. Lancet Digit Health. 2020;2(6):e323-e330.

32. Yang X, Ma X, Don O, Song Y, Chen X, Liu J, Qu J, Feng Y. Mesenchymal stem cells combined with liraglutide relieve acute lung injury through apoptotic signaling restrained by PKA/β-catenin. Stem Cell Res Ther. 2020;11(1):182.

33. Tang W, Cao Z, Han M, Wang Z, Chen J, Sun W, Wu Y, Xiao W, Liu S, Chen E, Chen W, Wang X, Yang J, Lin J, Zhao Q, Yan Y, Xie Z, Li D, Yang Y, Liu L, Qu J, Ning G, Shi G, Xie Q. Hydroxychloroquine in patients with mainly mild to moderate coronavirus disease 2019: open label, randomised controlled trial. BMJ. 2020;369:m1849.

34. Feng Y, Ling Y, Bai T, Xie Y, Huang J, Li J, Xiong W, Yang D, Chen R, Lu F, Lu Y, Liu X, Chen Y, Li X, Li Y, Summah HD, Lin H, Yan J, Zhou M, Lu H, Qu J. COVID-19 with Different Severities: A Multicenter Study of Clinical Features. Am J Respir Crit Care Med. 2020;201(11):1380-1388.

35. Liu Y, Mao B, Liang S, Yang JW, Lu HW, Chai YH, Wang L, Zhang L, Li QH, Zhao L, He Y, Gu XL, Ji XB, Li L, Jie ZJ, Li Q, Li XY, Lu HZ, Zhang WH, Song YL, Qu JM, Xu JF; Shanghai Clinical Treatment Experts Group for COVID-19. Association between age and clinical characteristics and outcomes of COVID-19. Eur Respir J. 2020;55(5):2001112.

36. Duan K, Liu B, Li C, Zhang H, Yu T, Qu J, Zhou M, Chen L, Meng S, Hu Y, Peng C, Yuan M, Huang J, Wang Z, Yu J, Gao X, Wang D, Yu X, Li L, Zhang J, Wu X, Li B, Xu Y, Chen W, Peng Y, Hu Y, Lin L, Liu X, Huang S, Zhou Z, Zhang L, Wang Y, Zhang Z, Deng K, Xia Z, Gong Q, Zhang W, Zheng X, Liu Y, Yang H, Zhou D, Yu D, Hou J, Shi Z, Chen S, Chen Z, Zhang X, Yang X. Effectiveness of convalescent plasma therapy in severe COVID-19 patients. Proc Natl Acad Sci U S A. 2020;117(17):9490-9496.

37. Yang W, Cao Q, Qin L, Wang X, Cheng Z, Pan A, Dai J, Sun Q, Zhao F, Qu J, Yan F. Clinical characteristics and imaging manifestations of the 2019 novel coronavirus disease (COVID-19):A multi-center study in Wenzhou city, Zhejiang, China. J Infect. 2020;80(4):388-393.

38. Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, Qiu Y, Wang J, Liu Y, Wei Y, Xia J, Yu T, Zhang X, Zhang L. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020;395(10223):507-513.

39. Zhang J, Hu W, Huang Y, Qu J; Infection Assembly of the Chinese Thoracic Society. Blind Spots of Traditional Microbiological Tests for Severe Community-Acquired Pneumonia in Adults and Availability of Nonculture Techniques: A Nationwide Survey of Physicians in China. J Infect Dis. 2020;221(Suppl 2):S198-S205.

40. Zhou YQ, Shi Y, Yang L, Sun YF, Han YF, Zhao ZX, Wang YJ, Liu Y, Ma Y, Zhang T, Ren T, Dale TP, Forsyth NR, Jin FG, Qu JM, Zuo W, Xu JF. Genetically engineered distal airway stem cell transplantation protects mice from pulmonary infection. EMBO Mol Med. 2020;12(1):e10233.

41. Feng Y, Wang L, Ma X, Yang X, Don O, Chen X, Qu J, Song Y. Effect of hCMSCs and liraglutide combination in ALI through cAMP/PKAc/β-catenin signaling pathway. Stem Cell Res Ther. 2020;11(1):2.

42. Ni Y, Shi G, Qu J. Indoor PM2.5, tobacco smoking and chronic lung diseases: A narrative review. Environ Res. 2020;181:108910.

43. Hu WP, Zhang FY, Zhang J, Hang JQ, Zeng YY, Du CL, Jie ZJ, Jin XY, Zheng CX, Luo XM, Huang Y, Cheng QJ, Qu JM. Initial diagnosis and management of adult community-acquired pneumonia: a 5-day prospective study in Shanghai. J Thorac Dis. 2020;12(4):1417-1426.

44. Huang Y, Jiao Y, Zhang J, Xu J, Cheng Q, Li Y, Liang S, Li H, Gong J, Zhu Y, Song L, Rong Z, Liu B, Jie Z, Sun S, Li P, Wang G, Qu J; Infection Assembly of Shanghai Respiratory Society. Microbial Etiology and Prognostic Factors of Ventilator-associated Pneumonia: A Multicenter Retrospective Study in Shanghai. Clin Infect Dis. 2018;67(suppl_2):S146-S152.

45. Liu HX, Tao LL, Zhang J, Zhu YG, Zheng Y, Liu D, Zhou M, Ke H, Shi MM, Qu JM. Difference of lower airway microbiome in bilateral protected specimen brush between lung cancer patients with unilateral lobar masses and control subjects. Int J Cancer. 2018;142(4):769-778.

46. Wei D, Yu DM, Wang MJ, Zhang DH, Cheng QJ, Qu JM, Zhang XX. Genome-wide characterization of the seasonal H3N2 virus in Shanghai reveals natural temperature-sensitive strains conferred by the I668V mutation in the PA subunit. Emerg Microbes Infect. 2018;7(1):171.

47. Liu D, Yan Y, Chen JW, Yuan P, Wang XJ, Jiang R, Wang L, Zhao QH, Wu WH, Simonneau G, Qu JM, Jing ZC. Hypermethylation of BMPR2 Promoter Occurs in Patients with Heritable Pulmonary Arterial Hypertension and Inhibits BMPR2 Expression. Am J Respir Crit Care Med. 2017;196(7):925-928.

48. Tang XD, Shi L, Monsel A, Li XY, Zhu HL, Zhu YG, Qu JM. Mesenchymal Stem Cell Microvesicles Attenuate Acute Lung Injury in Mice Partly Mediated by Ang-1 mRNA. Stem Cells. 2017;35(7):1849-1859.

49. Liu D, Liu QQ, Guan LH, Jiang X, Zhou DX, Beghetti M, Qu JM, Jing ZC. BMPR2 mutation is a potential predisposing genetic risk factor for congenital heart disease associated pulmonary vascular disease. Int J Cardiol. 2016;211:132-6.

50. Liu D, Wu BX, Sun N, Yan Y, Yuan P, Qu JM, Jing ZC. Elevated Levels of Circulating Bone Morphogenetic Protein 7 Predict Mortality in Pulmonary Arterial Hypertension. Chest. 2016;150(2):367-73.

51. Mao YX, Xu JF, Seeley EJ, Tang XD, Xu LL, Zhu YG, Song YL, Qu JM. Adipose Tissue-Derived Mesenchymal Stem Cells Attenuate Pulmonary Infection Caused by Pseudomonas aeruginosa via Inhibiting Overproduction of Prostaglandin E2. Stem Cells. 2015;33(7):2331-42.

52. Zhang J, Zhang YL, Ma KX, Qu JM. Efficacy and safety of adjunctive anticoagulation in patients with lung cancer without indication for anticoagulants: a systematic review and meta-analysis. Thorax. 2013;68(5):442-50.

53. Liu KX, Zhu YG, Zhang J, Tao LL, Lee JW, Wang XD, Qu JM. Probiotics' effects on the incidence of nosocomial pneumonia in critically ill patients: a systematic review and meta-analysis. Crit Care. 2012;16(3):R109.

54. Xu J, Qu J, Cao L, Sai Y, Chen C, He L, Yu L. Mesenchymal stem cell-based angiopoietin-1 gene therapy for acute lung injury induced by lipopolysaccharide in mice. J Pathol. 2008;214(4):472-81.