Biography

• Feng Gao, M.D., Ph.D., doctoral supervisor and advanced professor of Shanghai Jiao Tong University School of Medicine. He is also the special expert honored by the State of Council of P.R. China. Dr. Gao is currently a principal investigator in the Department of Molecular Biology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, and also serves as vice chairman of the Shanghai Clinical Laboratory Physicians Association as well as chief member of the Clinical Immunology Technology of Shanghai Society of Immunology. He was awarded the Shanghai Leading Talents in 2013 and the Shanghai Academic Research Leaders in 2011, and won the title of the Third National "Bethune's Good Doctor". Dr. Gao has dedicated to study the mechanisms underlying extracellular matrix and tumor metastasis and has found the new role of CD44 and hyaluronan in breast cancer cells collective invasion. He has been granted by the National High-tech Research and Development Program (863 Program) and the National Natural Science Foundation of China. Dr. Gao has published more than 100 papers in journals such as Oncogene, J Biol Chem, FASEB J, FEBS J, and has obtained two National Invention Patent. Dr. Gao is awarded the Distinguished Doctoral Supervisor of Shanghai Jiao Tong University and the Doctoral Supervisor of the Zhiyuan Honorary Program for Ph.D. Students of Shanghai Jiao Tong University School of Medicine.

Selected publications

1. Qian Guo, Yaqi Qiu, Yiwen Liu, Yiqing He, Guoliang Zhang, Yan Du, Cuixia Yang, Feng Gao*. Cell adhesion molecule CD44v10 promotes stem-like properties in triple-negative breast cancer cells via glucose transporter GLUT1-mediated glycolysis. J Biol Chem. 2022 Oct 12:102588.

2. Yan Du, Manlin Cao, Yiwen Liu, Yiqing He, Cuixia Yang, Guoliang Zhang, Youben Fan, Feng Gao*. Tumor microenvironment remodeling modulates macrophage phenotype in breast cancer lymphangiogenesis. FASEB J. 2022 Apr;36(4):e22248.

3. Guoliang Zhang, Yiqing He, Yiwen Liu, Yan Du, Cuixia Yang, Feng Gao*. Reduced hyaluronan cross-linking induces breast cancer malignancy in a CAF-dependent manner. Cell Death Dis. 2021 Jun 7; 12(6):586.

4. Cuixia Yang, Yumeng Sheng, Xiaoxing Shi, Yiwen Liu, Yiqing He, Yan Du, Guoliang Zhang, Feng Gao*. CD44/HA signaling mediates acquired resistance to a PI3Kα inhibitor. Cell Death Dis. 2020 Oct 6;11(10):831.

5. Xiaoyan Chen, Xiaoxing Shi, Yiwen Liu, Yiqing He, Yan Du, Guoliang Zhang, Cuixia Yang, Feng Gao*. Remodelling of the bone marrow microenvironment by stromal hyaluronan modulates the malignancy of breast cancer cells. Cell Commun Signal. 2020 Jun 9;18(1):89.

6. Cuixia Yang, Manlin Cao, Yiwen Liu, Yiqing He, Yan Du, Guoliang Zhang, Feng Gao*. Inducible Formation of Leader Cells Driven by CD44 Switching Gives Rise to Collective Invasion and Metastases in Luminal Breast Carcinomas. Oncogene. 2019 Nov; 38(46):7113-7132.

7. Guoliang Zhang, Renquan Lu, Man Wu, Yiwen Liu, Yiqing He, Jing Xu, Cuixia Yang, Yan Du, Feng Gao *. Colorectal cancer-associated ~ 6 kDa hyaluronan serves as a novel biomarker for cancer progression and metastasis. FEBS J. 2019 Aug;286(16):3148-3163.

8. Zhiming Jin, Guoliang Zhang, Yiwen Liu, Yiqing He, Cuixia Yang, Yan Du, Feng Gao*. The suppressive role of HYAL1 and HYAL2 in the metastasis of colorectal cancer. J Gastroenterol Hepatol. 2019 Oct;34(10):1766-1776.

9. Boke Zhang, Yan Du, Yiqing He, Yiwen Liu, Guoliang Zhang, Cuixia Yang, Feng Gao*. INT-HA induces M2-like macrophage differentiation of human monocytes via TLR4-miR-935 pathway. Cancer Immunol Immunother. 2019 Feb;68(2):189-200.

10. Yan Du, Manlin Cao, Yiwen Liu, Yiqing He, Cuixia Yang, Man Wu, Guoliang Zhang, Feng Gao*. Low-molecular-weight hyaluronan (LMW-HA) accelerates lymph node metastasis of melanoma cells by inducing disruption of lymphatic intercellular adhesion. Oncoimmunology. 2016 Sep 9;5(11):e1232235.

11. Guoliang Zhang, Lin Guo, Cuixia Yang, Yiwen Liu, Yiqing He, Yan Du, Wenjuan Wang, Feng Gao*. A novel role of breast cancer-derived hyaluronan on inducement of M2-like tumor-associated macrophages formation. Oncoimmunology. 2016 Apr 29;5(6):e1172154.

12. Man Wu, Manlin Cao, Yiqing He, Yiwen Liu, Cuixia Yang, Yan Du, Wenjuan Wang, Feng Gao*. A novel role of low molecular weight hyaluronan in breast cancer metastasis. FASEB J. 2015 Apr;29(4):1290-8.

13. Mengsi Yu, Huizhen Zhang, Yiwen Liu, Yiqing He, Cuixia Yang, Yan Du, Man Wu, Guoliang Zhang, Feng Gao*. The cooperative role of S1P3 with LYVE-1 in LMW-HA-induced lymphangiogenesis. Exp Cell Res. 2015 Aug 1;336(1):150-7.

14. Cuixia Yang, Yiwen Liu, Yiqing He, Yan Du, Wenjuan Wang, Xiaoxing Shi, Feng Gao*. The use of HA oligosaccharide-loaded nanoparticles to breach the endogenous hyaluronan glycocalyx for breast cancer therapy. Biomaterials. 2013 Sep;34(28): 6829-6838.

15. Muqing Zhou, Yan Du, Yiwen Liu, Yingzhi Wang, Yiqing He, Cuixia Yang, Wenjuan Wang, Feng Gao*. Clinical and experimental studies regarding the expression and diagnostic value of carcinoembryonic antigen-related cell adhesion molecule 1 in non-small-cell lung cancer. BMC Cancer. 2013 Jul 25;13:359

16. Cuixia Yang, Manlin Cao, Hua Liu, Yiqing He, Jing Xu, Yan Du, Yiwen, Liu, Wenjuan Wang, Lian Cui, Jiajie Hu, Feng Gao*. The high and low molecular weight forms of hyaluronan have distinct effects on CD44 clustering. J Biol Chem. 2012 Dec 14; 287(51):43094-107.

17. Feng Gao*, Yiwen Liu, Yiqing He, Cuixia Yang, Yingzhi Wang, Xiaoxing Shi, Wei Guo. Hyaluronan oligosaccharides promote excisional wound healing through enhanced angiogenesis. Matrix Biol. 2010 Mar;29(2):107-16.