Dr. Yingbin Liu, a leading biliary and pancreatic surgeon and oncologist, has been engaged in the field of hepatobiliary and pancreatic cancer between bedside and bench since 1984. His current research is focused on comprehensive diagnosis and treatment of biliary and pancreatic tumors, and on tumorigenesis and heterogeneity of tumor microenvironment.

Dr. Liu accomplished an innovative study on binding pancreaticojejunostomy anastomosis technique in 2005, which made a significant breakthrough in clinical surgery. In addition, he put forward the concept of total mesopancreas excision for pancreatic head carcinoma for the first time in China.

His research also cast a light on understanding the mechanisms that underlie hepatobiliary and pancreatic cancer. He identified somatic mutation and single cell heterogeneity of gallbladder cancer, and proposed the key tumor-driving genes and signal pathways (e.g. ErbB signal pathway) and their regulations on microenvironment. He has supervised more than 30 postgraduate and Ph.D. students and post-doctoral scholars and published more than 70 papers in peer-reviewed journals, including Nature Genetics, Journal of Hepatology, Gut and many others, in the research field of stomach, liver and gallbladder cancers.

Dr. Liu’s clinical and research contributions have been acknowledged by numerous awards, including Distinguished Professor of Yangtze River Scholars, Laureate of National ‘May 1st’ Labor Medal, and National Science and Technology Award.

Sep 1997 – Jul 2000: Ph.D. of General Surgery, Zhejiang University School of Medicine. Thesis advisor: Professor Shuyou Peng.

Sep 1994 – Jul 1997: M.S. of General Surgery, Jiangxi Medical College.  Thesis advisor: Professor Xiaoqiang Jiang.

Jun 2020 – Present: Chief Physician, Department of Biliary and Pancreatic Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University

Sep 2008 – Jun 2020: Chief Physician, Department of General Surgery, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University

Jul 2000 – Aug 2008: Associate Chief Physician, Department of General Surgery, The Second Affiliated Hospital of Zhejiang University School of Medicine

Sep 1984 – Aug 1994: Resident Surgeon & Attending Physician, Department of General Surgery, Baode County People’s Hospital, Shanxi Province

Surgical therapy of malignancy of digestive system

Clinical and basic research of biliary and pancreatic disease

Molecular biological mechanism research on tumorigenesis and development of gallbladder cancer

Standardized surgical resection of cholangiocarcinoma

Standardized surgical resection and comprehensive treatment of pancreatic cancer

Distinguished Professor of Yangtze River Scholars from the Ministry of Education（2012）

Laureate of National Millions of Talents Program（2014）

Distinguished Experts with Outstanding Contributions from the National Health and Family Planning Commission（2017）

Laureate of National ‘May 1st’ Labor Medal（2014）

Shanghai Master（2019）

Shanghai Science and Technology Elite（2018）

Shanghai Leading Talent（2011）

Shanghai Excellent Academic Leader（2011）

International Fellow of the American College of Surgeons (2016)

Shanghai Natural Science Award（2016)

Huaxia Medical Science and Technology Award（2016)

Natural Science Award of Colleges and Universities of the Ministry of Education (2017)

Science and Technology Progress Award of the Ministry of Education (2017)

Chinese Medical Science and Technology Award (2017)

the 19th Wu Jie Ping Medical Research Award, Paul Janssen Pharmaceutical Research Award (2018)National Science and Technology Progress Award (2005)

the National 863 Science and Technology Program of the Ministry of Science and Technology

the National Natural Science Foundation of China (9 funds, including 1 Key Project and 1 International Cooperation Project)

the Key Basic Program of Shanghai Committee of Science and Technology

the Nano Special Fund of Shanghai

the Natural Science Foundation of Zhejiang Province

the Key Program of Science and Technology Department of Zhejiang Province

the Program of Health Department of Zhejiang Province

Member, Division of Liver, Branch of Surgery, Chinese Medical Association.

Council Member, Branch of Surgery, Chinese Medical Doctor Association

Vice Director, Specialty Committee of Surgery, Shanghai Surgical Society

Vice Director, Specialty Committee of General Surgery, Shanghai Medical Association

Director, Specialty Committee of General Surgery, Shanghai Medical Doctor Association

Director designate, Specialty Committee of Biliary Tract Cancer, Chinese Anticancer Association.

Vice Director, Specialty Committee of Pancreatic Disease, China Research Hospital Association

Chinese Journal of Practical Surgery

Chinese Journal of Surgery

Chinese Medical Journal

Chinese Medical Journal (English version)

Chinese Journal of Digestive Surgery

Chinese Journal of Hepatobiliary Surgery

Shanghai Medical Journal

Journal of Surgery Concepts & Practice

79 publications referenced in Pubmed

Yijian Zhang, Chunman Zuo, Liguo Liu, Yunping Hu, Bo Yang, Shimei Qiu, Yang Li, Dongyan Cao, Zheng Ju, Jing Ge, Qiu Wang, Ting Wang, Lu Bai, Yang Yang , Guoqiang Li, Ziyu Shao, Yuan Gao, Yongsheng Li, Rui Bian, Huijie Miao, Lin Li, Xuechuan Li, Chengkai Jiang, Siyuan Yan, Ziyi Wang, Zeyu Wang, Xuya Cui  , Wen Huang, Dongxi Xiang, Congjun Wang, Qiyun Li, Xiangsong Wu, Wei Gong , Yun Liu, Rong Shao, Fatao Liu, Maolan Li, Luonan Chen, Yingbin Liu. Single-cell RNA-sequencing atlas reveals an MDK-dependent immunosuppressive environment in ErbB pathway-mutated gallbladder cancer. J Hepatol. 2021 Nov;75(5):1128-1141. (IF=30.083)

Fatao Liu, Yongsheng Li, Dongjian Ying, Shimei Qiu, Yong He, Maolan Li, Yun Liu, Yijian Zhang, Qin Zhu, Yunping Hu, Liguo Liu, Guoqiang Li, Weihua Pan, Wei Jin, Jiasheng Mu, Yang Cao & Yingbin Liu . Whole-exome mutational landscape of neuroendocrine carcinomas of the gallbladder. Signal Transduction and Targeted Therapy. 2021 Feb 10;6(1):55. (IF=13.496)

Maolan Li, Fatao Liu, Fei Zhang, Weiping Zhou, Xiaoqing Jiang, Yuan Yang, Kai Qu, Yueqi Wang, Qiang Ma, Ting Wang, Lu Bai, Zheng Wang, Xiaoling Song, Yidi Zhu, Ruiyan Yuan, Yuan Gao, Yongchen Liu, Yunpeng Jin, Huaifeng Li, Shanshan Xiang, Yuanyuan Ye, Yijian Zhang, Lin Jiang, Yunping Hu, Yajuan Hao, Wei Lu, Shili Chen, Jun Gu, Jian Zhou, Wei Gong, Yong Zhang, Xuefeng Wang, Xiyong Liu, Chang Liu, Houbao Liu, Yun Liu, Yingbin Liu. Genomic ERBB2/ERBB3 mutations promote PD-L1-mediated immune escape in gallbladder cancer: a whole-exome sequencing analysis. Gut. 2019, 68(6): 1024-1033.（IF=17.943）

YunPing Hu, YunPeng Jin, XiangSong Wu, Yang Yang, YongSheng Li, HuaiFeng Li, ShanShan Xiang, XiaoLing Song, Lin Jiang, YiJian Zhang, Wen Huang, ShiLi Chen, FaTao Liu, Chen Chen, Qin Zhu, HongZhuan Chen, Rong Shao, Ying-Bin Liu. LncRNA-HGBC stabilized by HuR promotes gallbladder cancer progression by regulating miR-502-3p/SET/AKT axis. Molecular Cancer. 2019 Nov 21;18(1):167.（IF=10.679）

Maolan Li, Zhou Zhang, Xiaoguang Li, Junyi Ye, Xiangsong Wu, Zhujun Tan, Chang Liu, Baiyong Shen, Xu’an Wang, Wenguang Wu, Daizhan Zhou, Di Zhang, Ting Wang, Bingya Liu, Kai Qu, Qichen Ding, Hao Weng, Qian Ding, Jiasheng Mu, Yijun Shu, Runfa Bao, Yang Cao, Peizhan Chen, Tianyu Liu, Lin Jiang, Yunping Hu, Ping Dong, Jun Gu, Wei Lu, Weibin Shi, Jianhua Lu, Wei Gong, Zhaohui Tang, Yong Zhang, Xuefeng Wang, Y Eugene Chin, Xiaoling Weng, Hong Zhang, Wei Tang, Yonglan Zheng, Lin He, Hui Wang, Yun Liu & Yingbin Liu. Whole-exome and targeted gene sequencing of gallbladder carcinoma identifies recurrent mutations in the ErbB pathway. Nat Genet. 2014 Aug;46(8):872-6. (IF= 27.959)