Research Interests

• The mechanism of the thyroid diseases such as autoimmune thyroid disease and congenital hypothyroidism

• Huaidong Song is a director and Professor in Department of Molecular Diagnostics & Endocrinology at Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine. He is a winner of “New Century National Hundred, Thousand and Ten Thousand Talent Project (China)”, “National Award for Youth in Science and Technology (China)”, “First Prize of Natural Science Award of the Ministry of Education” (2005), “Second Prize of National Natural Science Award”(2004). He has been funded by more than 10 projects form the National Natural Science Foundation of China and National Key R&D Program of China. His major research interest is to study the pathogenesis of thyroid diseases. His group has discovered 8 novel genes which contributed to the susceptibility of Graves’ disease by Genome-wide association study (GWAS). His group identified that AITD are existed as different subtypes underlining specific molecular mechanisms which needed to be optimal treated. They further discovered the deficiency of genes involved in the late stages of thyroid development resulted in congenital hypothyroidism. Their work has been published more than 150 articles in Journals such as Nature genetics, Science, Nature Communications, PNAS, which have been cited more than 6500.

Selected publications

1. Qian-Yue Zhang*, Xiao-Ping Ye*#, Zheng Zhou*, Chen-Fang Zhu*, Rui Li, Ya Fang, Rui-Jia Zhang, Lu Li, Wei Liu, Zheng Wang, Shi-Yang Song, Sang-Yu Lu, Shuang-Xia Zhao, Jian-Nan Lin #, Huai-Dong Song#. Thyroidal stromal and immune cell subsets promote lymphocyte infiltration and thyrocyte destruction in Hashimoto’s thyroiditis. Nat Commun. 2022 Feb 9;13(1):775. (corresponding author)

2. Rui-Meng Yang *, Ming Zhan *, Qin-Yi Zhou *, Xiao-Ping Ye *, Feng-Yao Wu *, Mei Dong, Feng Sun, Ya Fang, Rui-Jia Zhang, Chang-Run Zhang, Liu Yang, Miao-Miao Guo, Jun-Xiu Zhang, Jun Liang, Feng Cheng, Wei Liu, Bing Han, Yi Zhou , Shuang-Xia Zhao#, Huai-Dong Song#. Upregulation of GBP1 in thyroid primordium is required for developmental thyroid morphogenesis. Genet Med. 2021 Jun 30. doi: 10.1038/s41436-021-01237-3. Online ahead of print. (corresponding author)

3. Chu X*, Pan CM*, Zhao SX*, Liang J*, Gao GQ*, Zhang XM*, Yuan GY, Li CG, Xue LQ, Shen M, Liu W, Xie F, Yang SY, Wang HF, Shi JY, Sun WW, Du WH, Zuo CL, Shi JX, Liu BL, Guo CC, Zhan M, Gu ZH, Zhang XN, Sun F, Wang ZQ, Song ZY, Zou CY, Sun WH, Guo T, Cao HM, Ma JH, Han B, Li P, Jiang H, Huang QH, Liang L, Liu LB, Chen G, Su Q, Peng YD, Zhao JJ, Ning G#, Chen Z#, Chen JL#, Chen SJ#, Huang W#, Song HD#. A genome-wide association study identifies two new risk loci for Graves' disease. Nat Genet. 2011 Aug 14;43(9):897-901. (corresponding author)

4. Sun F*, Zhang JX*, Yang CY*, Gao GQ*, Zhu WB, Han B, Zhang LL, Wan YY, Ye XP, Ma YR, Zhang MM, Yang L, Zhang QY, Liu W, Guo CC, Chen G, Zhao SX, Song KY, Song HD. The genetic characteristics of congenital hypothyroidism in China by comprehensive screening of 21 candidate genes. Eur J Endocrinol. 2018 Jun;178(6):623-633. (corresponding author)

5. Zhang QY, Liu W, Li L, Du WH, Zuo CL, Ye XP, Zhou Z, Yuan FF, Ma YR, Sun F, Yu SS, Xie HJ, Zhang CR, Ying YX, Yuan GY, Gao GQ, Liang J, Zhao SX, Song HD. Genetic study in a large cohort supported different pathogenesis of Graves' diseases and Hashimoto's hypothyroidism. J Clin Endocrinol Metab. 2020 Jul 1;105(7):dgaa170. doi: 10.1210/clinem/dgaa170. (corresponding author)

6. Zhao SX*, Xue LQ*, Liu W*, Gu ZH*, Pan CM*, Yang SY*, Zhan M, Wang HN, Liang J, Gao GQ, Zhang XM, Yuan GY, Li CG, Du WH, Liu BL, Liu LB, Chen G, Su Q, Peng YD, Zhao JJ, Ning G, Huang W, Liang L, Qi L, Chen SJ, Chen Z, Chen JL, Song HD#. Robust evidence for five new Graves' disease risk loci from a staged genome-wide association analysis. Hum Mol Genet. 2013;22(16):3347-62. (corresponding author)

7. Song HD*#, Liang J*, Shi JY*, Zhao SX*, Liu Z*, Zhao JJ*, Peng YD, Gao GQ, Tao J, Pan CM, Shao L, Cheng F, Wang Y, Yuan GY, Xu C, Han B, Huang W, Chu X, Chen Y, Sheng Y, Li RY, Su Q, Gao L, Jia WP, Jin L, Chen MD, Chen SJ, Chen Z, Chen JL. Functional SNPs in the UGRP1 promoter are associated with susceptibility to Graves’ disease. Hum Mol Genet. 2009 Mar 15;18(6):1156-70. (corresponding author)

8. Zhao SX, Liu W, Liang J, Gao GQ, Zhang XM, Yao Y, Wang HN, Yuan FF, Xue LQ, Ma YR, Zhang LL, Ye XP, Zhang QY, Sun F, Zhang RJ, Yang SY, Zhan M, Du WH, Liu BL, Chen X, Song ZY, Li XS, Li P, Ru Y, Zuo CL, Li SX, Han B, Zhu H, Qiao J, Xuan M, Su B, Sun F, Ma JH, Chen JL, Tian HM, Chen SJ, Song HD. Assessment of Molecular Subtypes in Thyrotoxic Periodic Paralysis and Graves Disease Among Chinese Han Adults: A Population-Based Genome-Wide Association Study. JAMA Netw Open. 2019 May 3;2(5):e193348. (corresponding author)

9. Epidemiology group: Jian-Feng He*,  Guo-Wen Peng, Jun Min,  De-Wen Yu, Wen-Jia Liang, Shu-Yi Zhang, Rui-Heng Xu# Virology group: Huan-Ying Zheng*,  Xin-Wei Wu*, Jun Xu, Zhan-Hui Wang, Ling Fang, Xin Zhang, Hui Li, Xin-Ge Yan, Jia-Hai Lu, Zhi-Hong Hu, Ji-Cheng Huang, Zhuo-Yue Wan#,  Jin-Lin Hou#, Jin-Yan Lin# Molecular biology group: Huai-Dong Song*,  Sheng-Yue Wang*,  Xiang-Jun Zhou*, Guo-Wei Zhang, Bo-Wei Gu, Hua-Jun Zheng, Xiang-Lin Zhang, Mei He, Kui Zheng, Bo-Fei Wang, Gang Fu, Xiao-Ning Wang, Sai-Juan Chen, Zhu Chen# Data analysis group: Pei Hao*,  Hua Tang*,  Shuang-Xi Ren*,  Yang Zhong*，Zong-Ming Guo, Qi Liu,11 You-Gang Miao, Xiang-Yin Kong, Wei-Zhong He, Yi-Xue Li, Chung-I Wu#，Guo-Ping Zhao#§ Chinese University of Hong Kong group: Rossa W. K. Chiu*,  Stephen S. C. Chim, Yu-kwan Tong, Paul K. S. Chan, John S. Tam, Y. M. Dennis Lo#.  Molecular Evolution of the SARS Coronavirus During the Course of the SARS Epidemic in China. Science 2004;303(5664):1666-9. (Co-first author)

10. Song HD*, Tu CC*, Zhang GW*, Wang SY*, Zheng K, Lei LC, Chen QX, Gao YW, Zhou HQ, Xiang H, Zheng HJ, Chern SW, Cheng F, Pan CM, Xuan H, Chen SJ, Luo HM, Zhou DH, Liu YF, He JF, Qin PZ, Li LH, Ren YQ, Liang WJ, Yu YD, Anderson L, Wang M, Xu RH, Wu XW, Zheng HY, Chen JD, Liang G, Gao Y, Liao M, Fang L, Jiang LY, Li H, Chen F, Di B, He LJ, Lin JY, Tong S, Kong X, Du L, Hao P, Tang H, Bernini A, Yu XJ, Spiga O, Guo ZM, Pan HY, He WZ, Manuguerra JC, Fontanet A, Danchin A, Niccolai N, Li YX, Wu CI, Zhao GP#. Cross-host evolution of severe acute respiratory syndrome coronavirus in palm civet and human. Proc Natl Acad Sci U S A. 2005;102(7):2430-5. (Co-first author)