Research Interests

• The pathogenic mechanisms underlying vascular cognitive impairment and dementia (VCID) remain controversial due to the heterogeneity of vascular causes and complexity of disease neuropathology. Our current research emphasis is on the mechanisms involved in chronic cerebral hypoperfusion （CCH）-induced VCID pathological changes, including Aβ accumulation, inflammation, oxidative stress, mitophagy, blood-brain barrier (BBB) disruption, trophic uncoupling and white matter lesions (WMLs).