Research Interests

• Failure of chemotherapy or immunotherapy to effectively remove leukemia stem cells (LSCs) is the underlying mechanism of leukemia relapse. Recent studies have revealed that bone marrow (BM) niche provides a refuge for LSC to escape treatment. However, the role of different cellular components of the BM niche in the therapeutic resistance of leukemia is largely unclear.

  (1)BM niche regulates the mechanism of resistance to CAR-T immunotherapy in acute lymphoblastic leukemia (ALL)

  (2) BM vascular niche regulates drug-resistant relapse of MLL-AF4-positive ALL in infants and children

  (3) Role of chemotherapy-activated BM vascular niche in the immunotherapy of AML and its mechanism