Research Interests

• Prof. Chen is engaged in the study of pathogenesis and treatment of leukemia. She initiated Leukemia Genomic Anatomy Project and has obtained a series of novel molecular biomarkers and targets for disease classification, prognosis and targeted therapy. She led the team to innovate the synergistic targeted therapy for acute promyelocytic leukemia(APL) with all-trans retinoic acid and arsenic trioxide, and has turned APL from a fatal malignancy to a curable disease, which has been extended to other types of leukemia. Recently, the exploratory trial of a biepitopic CAR T-targeting B cell maturation antigen (LCAR-B38M) in relapsed/refractory multiple myeloma led by her has achieved significant effects. The above research work has profoundly promoted the development of hematology in China and exerted a considerable influence in international medical communities.