Research Interests

• Current research interests of Dr. Tian include the molecular mechanism of tumorigenesis and development, molecular targeted therapy. Dr. Tian has undertaken many important research projects such as National Natural Science Foundation of China, Natural Science Foundation of Shanghai and Specialized Research Fund for the Doctoral Program of Higher Education of China. Dr. Tian has published over 20 papers in international journals including Hepatology, Cancer Research, Oncogene. Dr. Tian is a reviewer of  Advanced Science, Cell Death and Differentiation, Oncogene, Cell Death & Disease,  Theranostics, Cellular Oncology, Acta Biochimica et Biophysica Sinica, Frontiers of Medicine, Cell Biology and Toxicology, etc.

Publications

1. Zhou Q, Li J, Ge C, Chen J, Tian W, Tian H*. SNX5 suppresses clear cell renal cell carcinoma progression by inducing CD44 internalization and epithelial-to-mesenchymal transition. Mol Ther Oncolytics. 2022;24:87-100

2. Zhou Q, Tian W, Jiang Z, Huang T, Ge C, Liu T, Zhao F, Chen T, Cui Y, Li H, Yao M, Li J, Tian H*. A Positive Feedback Loop of AKR1C3-Mediated Activation of NF-κB and STAT3 Facilitates Proliferation and Metastasis in Hepatocellular Carcinoma. Cancer Res, 2021;81(5):1361-1374.Sun T*, Wei L, Tian H*, Zhan W, Ma H, Nie D, Wang S, Chen X, Tang G*. Novel PET/CT tracers for targeted imaging of membrane receptors to evaluate cardiomyocyte apoptosis and tissue repair process in a rat model of myocardial infarction. Apoptosis, 2021 Aug;26(7-8):460-473

3. Zhou Q, Huang T, Jiang Z, Ge C, Chen X, Zhang L, Zhao F, Zhu M, Chen T, Cui Y, Li H, Yao M, Li J, Tian H*. Upregulation of SNX5 predicts poor prognosis and promotes hepatocellular carcinoma progression by modulating the EGFR-ERK1/2 signaling pathway. Oncogene. 2020;39(10):2140-2155.

4. Cao Y, Wang J, Tian H*, Fu GH*. Mitochondrial ROS accumulation inhibiting JAK2/STAT3 pathway is a critical modulator of CYT997-induced autophagy and apoptosis in gastric cancer. J Exp Clin Cancer Res. 2020;39(1):119.

5. Wei L, Zhou Q, Tian H*, Su Y, Fu GH, Sun T*. Integrin β3 promotes cardiomyocyte proliferation and attenuates hypoxia-induced apoptosis via regulating the PTEN/Akt/mTOR and ERK1/2 pathways. Int J Biol Sci. 2020;16(4):644-654.

6. Jiang Z, Zhou Q, Ge C, Yang J, Li H, Chen T, Xie H, Cui Y, Shao M, Li J, Tian H*. Rpn10 promotes tumor progression by regulating hypoxia-inducible factor 1 alpha through the PTEN/Akt signaling pathway in hepatocellular carcinoma.Cancer Lett. 2019;447:1-11.

7. Hou H, Ge C, Sun H, Li H, Li J, Tian H*.Tunicamycin inhibits cell proliferation and migration in hepatocellular carcinoma through suppression of CD44s and the ERK1/2 pathway.Cancer Sci. 2018;109(4):1088-1100.

8. Tian H, Ge C, Zhao F, Zhu M, Zhang L, Huo Q, Li H, Chen T, Xie H, Cui Y, Yao M, Li J*.Downregulation of AZGP1 by Ikaros and histone deacetylase promotes tumor progression through the PTEN/Akt and CD44s pathways in hepatocellular carcinoma.Carcinogenesis. 2017;38(2):207-217.

9. Tian H, Ge C, Li H, Zhao F, Hou H, Chen T, Jiang G, Xie H, Cui Y, Yao M, Li J*.Ribonucleotide reductase M2B inhibits cell migration and spreading by early growth response protein 1-mediated phosphatase and tensin homolog/Akt1 pathway in hepatocellular carcinoma.Hepatology. 2014;59(4):1459-70.