Research Interests

• My research interest is the mechanisms of the development of the digestive system neoplasms, including hepatocellular carcinogenesis (HCC) and pancreatic cancer, from the aspect of cellular basic biological function regulation and also combined with the microenvironment or systematic clues. We preferred to study the mechanisms from aspects of cell cycle, cell mitosis, nucleolar function and microenvironment inputs. Our research articles were published in Gastroenterology, Journal of Hepatology, Cancer Research and et al.

• One of our main findings is to report the role of RacGAP1 in mediating cell cytokinesis in HCC and reveal new RacGAP1 dependent molecular links between cytokinesis and the Hippo pathway. As cytokinesis failure was tolerant in normal hepatocytes, strategies that blocking cancer cell cytokinesis might be promising in HCC treatment. Recently, we are interested in exploring mechanisms that specifically regulate cytokinesis and revealing their function in liver function and liver diseases. We are also interested in seeking important players that regulate nucleolar function and nuclear architecture to coordinate with cell cycle progress and microenvironment stress in cancers.