ZHANG XueLi
Associate Professor
Email:xlzhang@shsci.org
phone：021-34206022
Research interests:
1.Extracellular matrix in autoimmune disease and gastrointestinal tumors;
2.Mechanisms of different immune cells involved in tumor microenvironment
Biography
In 2009, Zhang graduated from Jilin University with a master's degree and received her doctor degree in biology from the University of Münster , Germany in July 2013 (supervisor: Prof Lydia Sorokin). From Oct 2013 to Jun 2017, she worked as a postdoctoral researcher at the Institute of Physiological Biochemistry and Pathological Biochemistry, School of Medicine, University of Münster, Germany. ln August 2017, she joined Shanghai Cancer Institute, focused on the research related to the tumor immune microenvironment.
As a project leader, she has chaired one Youth program of National Natural Science Foundation of China, two General Programs of Natural Science Foundation of Shanghai, and one General Program of Shanghai Municipal Health Commission. She has published more than 20 SCI papers as first author/co-first author and corresponding author/co-corresponding author, including Journal of Experimental Medicine, Nature Communications, Cell Death & Disease, Cell reports, Journal of Immunology etc.
Publications #first author，*corresponding author
Zhang XL#, Hu LP#, Yang Q#, Qin WT, Wang X, Xu CJ, Tian GA, Yang XM, Yao LL, Zhu L, Nie HZ, Li Q, Xu Q, Zhang ZG, Zhang YL*, Li J*, Wang YH*, Jiang SH*. CTHRC1 promotes liver metastasis by reshaping infiltrated macrophages through physical interactions withTGF-b receptors in colorectal cancer. Oncogene. 2021. In press.
Zhang XL#, Wang Y#, Song J#, Gerwien H, Chuquisana O, Chashchina A, Denz C, Sorokin L*. The endothelial basement membrane act as a check point for entry of pathogenic T cells into the brain. Journal of Experimental Medicine. 2020, 217(7): e20191339.
Wang Xu#, Hu LP#, Qin WT#, Yang Qin#, Chen DY#, Li Qing, Zhou KX, Huang PQ, Xu CJ, Li J, Yao LL, Wang YH, Tian GA, Yang JY, Yang MW, Liu DJ, Sun YW*, Jiang SH*, Zhang XL*, Zhang ZG*. Identification of a subset of immunosuppressive P2RX1-negative neutrophils in pancreatic cancer liver metastasis. Nature Communications. 2021, 12(1):174.
Zhang XL#, Wu C, Song J, Götte M, Sorokin L*. Syndecan-1, a cell surface proteoglycan, negatively regulates initial leukocyte recruitment to the brain across the choroid plexus in murine experimental autoimmune encephalomyelitis. Journal of Immunology. 2013, 191: 4551-4561.
Zhang S#, Huang PQ#, Dai HJ#, Li Q, Hu LP, Peng J, Jiang SH, Xu YQ, Wu ZP, Nie HZ, Zhang ZG, Yin WJ*, Zhang XL*, Lu JS*. TIMELESS regulates sphingolipid metabolism and tumor cell growth through Sp1/ACER2/S1P axis in ER-positive breast cancer. Cell Death & Disease. 2020, 11(10):892.
Yang Q#, Zhang CC#, Ren Y#, Yi H#, Luo TJ, Xing FL, Bai XF, Cui LN, Zhu LY, Ouyang J, Jiang PC, Fan WR, Qiu JP, Wang FM, Xing X, Zhang ZG, Zhang XL*, Zhang R*. Genomic characterization of Chinese ovarian clear cell carcinoma identifies driver genes by whole exome sequencing. Neoplasia. 2020, 22(9):399-430.
Zhang YL#, Xing X#, Cai LB#, Zhu L, Yang XM, Wang YH, Yang Q, Nie HZ, Zhang ZG, Li J*, Zhang XL*. Integrin a9 Suppresses Hepatocellular Carcinoma Metastasis by Rho GTPase Signaling. Journal of Immunology Research. 2018, 2018: 4602570.
Song J#, Zhang XL#, Buscher K#, Wang Y, Wang H, Di Russo J, Li L, Ludke-Enking S, Zarbock A, Stadtmann A, Striewski P, Wirth B, Kuzmanov I, Wiendl H, Schulte D, Vestweber D, Sorokin L*. Endothelial Basement Membrane Laminin 511 Contributes to Endothelial Junctional Tightness and thereby Inhibits Leukocyte Transmigration, Cell reports, 2017, 18(5):1256-1269.
Zhang S#, Dai Miao#, Wang X, Jiang SH, Hu LP, Zhang XL*, Zhang ZG*. Signalling entrains the peripheral circadian clock. Cellular Signalling. 2020, 69:109433.
10.Qin WT#, Hu LP#, Zhang XL#, Jiang SH, Li J, Zhang, ZG*, Wang X*. The diverse function of PD-1/PD-L pathway beyond cancer. Frontiers in immunology. 2019, 10: 2298.
