Boshi Wang received his PhD in Peking Union Medical College and joined Shanghai Cancer Institute in 2012. He has been doing research in the field of protein ubiquitination and degradation, systematically revealing the roles of deubiquitinase POH1 in tumor cells. Now, his main research interest is the roles of protein modification in transcriptional regulation and tumorigenesis. He has completed two projects from National Natural Science Foundation of China (NSFC) and two talent projects supported by Shanghai government. Now, he is leading two NSFC projects and one NSF-SH project.

Wu C, Liu Y, Wei D, Tao L, Yuan L, Jing T, Wang BS (Corresponding author). Gene Coexpression Network Characterizing Microenvironmental Heterogeneity and Intercellular Communication in Pancreatic Ductal Adenocarcinoma: Implications of Prognostic Significance and Therapeutic Target. Front Oncol. 2022 Jun 1;12:840474.

Xu X, Wang BS (co-first author), Liu Y, Jing T, Xu G, Zhang L, Kun Jiao, Chen Z, Xiang L, Xu C, Yang Z, Liu Y. ETV4 potentiates nuclear YAP retention and activities to enhance the progression of hepatocellular carcinoma. Cancer Lett. 2022 Jul 1;537:215640.

Yang Z, Xu G, Wang BS (co-first author), Liu Y, Zhang L, Jing T, Tang M, Xu X, Jiao K, Xiang L, Fu Y, Tang D, Zhang X, Jin W, Zhuang G, Zhao X, Liu Y. USP12 downregulation orchestrates a protumourigenic microenvironment and enhances lung tumour resistance to PD-1 blockade. Nat Commun. 2021 Aug 11;12(1):4852.

Jing T, Wang BS, Yang Z, Liu Y, Xu G, Xu X, Jiao K, Chen Z, Xiang L, Zhang L, Liu Y. Deubiquitination of the repressor E2F6 by USP22 facilitates AKT activation and tumor growth in hepatocellular carcinoma. Cancer Lett. 2021 Oct 10;518:266-277.

Wang BS (Corresponding author), Jing T, Jin W, Chen J, Wu C, Wang M, Liu Y. KIAA1522 potentiates TNFα-NFκB signaling to antagonize platinum-based chemotherapy in lung adenocarcinoma. J Exp Clin Cancer Res. 2020 Aug 27;39(1):170.

Hu H, Wang BS (co-first author), Jiang C, Li R, Zhao J.Endothelial progenitor cell-derived exosomes facilitate vascular endothelial cell repair through shuttling miR-21-5p to modulate Thrombospondin-1 expression. Clin Sci (Lond). 2019 Jul 25;133(14):1629-1644.

Wang BS, Xu XL, Yang ZJ, Zhang L, Liu Y, Ma AH, Xu GQ, Tang M, Jing TT, Wu L, Liu YZ. POH1 contributes to hyperactivation of TGF-β signaling and facilitates hepatocellular carcinoma metastasis through deubiquitinating TGF-β receptors and caveolin-1. EBioMedicine. 2019 Mar; 41:320-332.

Liu Y, Zhang L, Wang BS, Yang ZJ, Xu GQ, Ma AH, Tang M, Jing TT, Wu L, Xu XL, Liu YZ. Requirement for POH1 in differentiation and maintenance of regulatory T cells. Cell Death & Differentiation. 2019 Mar; 26(4):751-762.

Zhang L, Liu Y, Wang BS, Xu GQ, Yang ZJ, Tang M, Ma AH, Jing TT, Xu XL, Zhang XR, Liu YZ. POH1 deubiquitinates pro-interleukin-1β and restricts inflammasome activity. Nature Communications. 2018 Oct; 9(1):4225.

Liu YZ, Wang BS (co-first author), Jiang YY, Cao J, Hao JJ, Zhang Y, Xu X, Cai Y, Wang MR. MCMs expression in lung cancer: implication of prognostic significance. Journal of Cancer. 2017 Oct; 8(18):3641-3647.

Qian Y, Wang BS (co-first author), Ma AH, Zhang L, Xu GQ, Ding Q, Jing TT, Wu L, Liu Y, Yang ZJ, Liu YZ. USP16 Downregulation by Carboxyl-terminal Truncated HBx Promotes the Growth of Hepatocellular Carcinoma Cells. Scientific Reports. 2016 Sep; 6:33039.

Wang BS, Ma AH, Zhang L, Jin WL, Qian Y, Xu GQ, Qiu BJ, Yang ZJ, Liu Y, Xia Q, Liu YZ. POH1 deubiquitylates and stabilizes E2F1 to promote tumour formation. Nature Communications. 2015 Oct; 6:8704.

Wang BS, Yang Y, Lu HZ, Shang L, Zhang Y, Hao JJ, Shi ZZ, Wang XM, Liu YZ, Zhan QM, Jia XM, Wang MR. Inhibition of atypical protein kinase Cι induces apoptosis through autophagic degradation of β-catenin in esophageal cancer cells. Molecular Carcinogenesis. 2014 Jul; 53(7):514-25.

Wang BS, Yang Y, Yang H, Liu YZ, Hao JJ, Zhang Y, Shi ZZ, Jia XM, Zhan QM, Wang MR. PKCι Counteracts Oxidative Stress by Regulating Hsc70 in an Esophageal Cancer Cell Line. Cell stress & Chaperons. 2013 May; 18(3):359-66.

Wang BS, Liu YZ, Yang Y, Zhang Y, Hao JJ, Yang H, Wang XM, Zhang ZQ, Zhan QM, Wang MR. Autophagy negatively regulates cancer cell proliferation via selectively targeting VPRBP protein. Clinical Science. 2013 Feb; 124(3):203-14.