Shanghai Cancer Institute


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NIE HuiZhen

Email:hznie@shsci.org

phone:021-34206022

Research direction: Hormones and neurotransmitter in tumor; Metabolic reprogramming and macropinocytosis in liver and pancreatic cancer.

Education and Professional Experience

  • 2005.10-2008.07: Ph. D., School of Pharmacy, Shanghai Jiaotong University

  • 2008.07-2009.06: Research assistant, Center for excellence in molecular cell science, Chinese Academy of Sciences.

  • 2009.06-2011.05: Postdoc, School of Pharmacy, Shanghai Jiaotong University

  • 2011.06-2015.11: Research assistant, Shanghai Cancer Institute, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University

  • 2015.11-: Associate Researcher, Shanghai Cancer Institute, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University

  • Dr. Hui-Zhen Nie, female, was born in October 1979. The youth project leader and associate researcher of "State Key Laboratory of Oncogenes and Related Genes" of Shanghai Cancer Institute, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University (SJTU). In recent years, she has presided 2 General programs of National Natural Science Foundation of China (NSFC), 1 Youth program of NSFC, 2 Shanghai Natural Science Foundation, 1 Shanghai Municipal Health and Family Planning Commission General Project, 3 Innovation Fund of State Key Laboratory of Oncogenes and Related Genes, 3 Academician Foundation of Shanghai Cancer Institute. As the third adult, he got the second prize of Shanghai Medical Science and Technology Award.

Representative publication:

  1. Zhang YF#, Li Q#, Huang PQ#, Su T#, Jiang SH, Hu LP, Zhang XL, Sun Y, Pan H, Yang XM, Li J, Gai YZ, Zhu L, Yao LL, Li DX, Sun YW, Zhang ZG, Liu DJ, Zhang YL*, Nie HZ*. A low amino acid environment promotes cell macropinocytosis through the YY1-FGD6 axis in Ras-mutant pancreatic ductal adenocarcinoma. Oncogene. 2022; 41: 1203-1215.

  2. Nie HZ #, Huang PQ #, Jiang SH, Yang Q, Hu LP, Yang XM, Li J, Wang YH, Li Q, Zhang YF, Zhu L, Zhang YL, Yu YQ,Xiao GS, Sun YW*, Ji JG*, Zhang ZG*. The short isoform of PRLR suppresses the pentose phosphate pathway and nucleotide synthesis through the NEK9-Hippo axis in pancreatic cancer. Theranostics. 2021; 11(8): 3898-3915.

  3. Nie HZ, Li J, Yang XM, Cao QZ, Feng MX, Xue F, Wei L, Qin WX, Gu JR, Xia Q, Zhang ZG. Mineralocorticoid receptor suppresses cancer progression and the Warburg effect by modulating the miR-338-3p-PKLR axis in hepatocellular carcinoma. Hepatology. 2015 Oct;62(4):1145-59.

  4. Sun Y, Zhang XX, Huang S, Pan H, Gai YZ, Zhou YQ, Zhu L*, Nie HZ*, Li DX*. Diet-Induced Obesity Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma via CX3CL1/CX3CR1 Axis. J Immunol Res. 2022:5665964.

  5. Wang YH#, Huang S#, Zhu L#, Yang Q, Yang XM, Gu JR, Zhang ZG, Nie HZ*, Li J*. Alternative transcription start site selection in ACSS2 controls its nuclear localization and promotes ribosome biosynthesis in hepatocellular carcinoma. Biochem Biophys Res Commun. 2019;514(3):632-638.

  6. Nie HZ, Cao QZ, Zhu L, Gong YH, Gu JR, He ZP. Acetylcholine Acts on Androgen Receptor to Promote the Migration and Invasion but Inhibit the Apoptosis of Human Hepatocarcinoma. Plos One. 2013, 8(4): e61678.

  7. Nie HZ, Wang ZJ, Zhao WJ, Lu JM, Zhang C, KHL, Wang YL, Shen HL, Xu Z, Yin M*. New nicotinic analogue ZY-1 enhances cognitive functions in a transgenic mice model of Alzheimer’s disease. Neurosci lett. 2013, 537: 29-34.

  8. Nie HZ, Li ZQ, Yan QX ,Wang ZJ , Zhao WJ, Guo LC,Yin M*. Nicotine decreases beta-amyloid through regulating BACE1 transcription in SH-EP1-α4β2 nAChR-APP695 cells. Neurochem Res. 36(5): 904-912, 2011.

  9. Nie HZ, Shi S, RJL, Zhao WJ, Sun YN, Yin M*. Activation of α7 nicotinic receptor affects APP processing by regulating secretase activity in SH-EP1-α7 nAChR-hAPP695 cells. Brain Res. 14;1356: 112-120, 2010.

  10. Nie HZ, ZLQ, RJL, Shen YH, Song L, Wang X, Yin M.  Construction of SH-EP1-α4β2-hAPP695 cell line and effects of nicotinic agonists on β-amyloid in the cells. Cell Mol Neurobiol. 28:103-112,2008.

  11. Zhang S#, Huang PQ#, Dai HJ, Li Q, Hu LP, Peng J, Jiang SH, Xu YQ,  Wu ZP, Nie HZ, Zhang ZG, Yin WJ*, Zhang XL*, Lu JS*. TIMELESS regulates sphingolipid metabolism and tumor cell growth through Sp1/ACER2/S1P axis in ER-positive breast cancer. Cell Death Dis. 2020; 11(10):892.

  12. Yang XM#, Cao XY#, He P#, Li J, Feng MX, Zhang YL, Zhang XL, Wang YH, Yang Q, Zhu L, Nie HZ, Jiang SH, Tian GA, Zhang XX, Liu Q, Ji J, Zhu X, Xia Q*, Zhang ZG*. Overexpression of Rac GTPase activating protein 1 contributes to proliferation of cancer cells by reducing Hippo signaling to promote cytokinesis. Gastroenterology. 2018; 155(4): 1233-1249.

  13. Zhang YL#, Li Q#, Yang XM#, Fang F, Li J, Wang YH, Yang Q, Zhu L, Nie HZ, Zhang XL, Feng MX, Jiang SH, Tian GA, Hu LP, Lee HY, Lee SJ, Xia Q, Zhang ZG*. SPON2 Promotes M1-like macrophage recruitment and inhibits hepatocellular carcinoma metastasis by distinct integrin-Rho GTPase-Hippo pathways. Cancer Res. 2018; 78(9): 2305-2317.

  14. Jiang SH#, Zhu LL#, Zhang M#, Li RK#, Yang Q#, Yan JY, Zhang C, Yang JY, Dong FY, Dai M, Hu LP, Li J, Li Q, Wang YH, Yang XM, Zhang YL, Nie HZ, Zhu L, Zhang XL, Tian GA, Zhang XX, Cao XY, Tao LY, Huang S, Jiang YS, Hua R, Qian Luo K, Gu JR, Sun YW*, Hou S*, Zhang ZG*. GABRP regulates chemokine signalling, macrophage recruitment and tumour progression in pancreatic cancer through tuning KCNN4-mediated Ca2+ signalling in a GABA-independent manner. Gut. 2019 Nov;68(11):1994-2006.