Biography

• Dr. Yujun Hao received his Ph.D. in Institute of Genetics and Developmental Biology, Chinese Academy of Sciences in 2009, and worked as postdoctoral fellow with Dr. Zhenghe Wang in Case Western Reserve University school of medicine. Dr. Hao joined Shanghai Cancer Institute and Shanghai Jiao Tong University school of medicine affiliated Renji Hospital in August 2017. He was awarded with Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning (2017); Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support (2017) and Shanghai Academic/Technology Research Leader (2019). His research work focus on the mechanism of how oncogenic mutation of PIK3CA promote the tumorigenesis and targeted therapy strategy for such tumors. Another research interest is the reprogramming of metabolism in cancer and metabolic therapies for cancer.

Publications

1. Hao Y, Wang C, Cao B, Hirsch BM, Song J, Markowitz SD, Ewing RM, Sedwick D, Liu L, Zheng W, Wang Z. Gain of interaction with IRS1 by p110α-helical domain mutants is crucial for their oncogenic functions. Cancer Cell. 2013 May 13;23(5):583-93.

2. Hao Y, Samuels Y, Li Q, Krokowski D, Guan BJ, Wang C, Jin Z, Dong B, Cao B, Feng X, Xiang M, Xu C, Fink S, Meropol NJ, Xu Y, Conlon RA, Markowitz S, Kinzler KW, Velculescu VE, Brunengraber H, Willis JE, LaFramboise T, Hatzoglou M, Zhang GF, Vogelstein B, Wang Z. Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer. Nat Commun. 2016 Jun 20;7:11971.

3. Hao, Y, He B, Wu L, Li Y, Wang C, Wang T, Sun L, Zhang Y, Zhan Y, Zhao Y, Markowitz S, Veigl M, Conlon RA, Wang Z. Nuclear translocation of p85β promotes tumorigenesis of PIK3CA helical domain mutant cancer. Nat Commun. 2022 Apr 13;13(1):1974. (First and co-corresponding author)

4. Wang T, Jin H, Hu J, Li X, Ruan H, Xu H, Wei L, Dong W, Teng F, Gu J, Qin W, Luo X, Hao Y. COL4A1 promotes the growth and metastasis of hepatocellular carcinoma cells by activating FAK-Src signaling. J Exp Clin Cancer Res. 2020 Aug 3;39(1):148.

5. He B, Chao W, Huang Z, Zeng J, Yang J, Luo D, Huang S, Pan H, Hao Y. Hsa_circ_001659 serves as a novel diagnostic and prognostic biomarker for colorectal cancer. Biochem Biophys Res Commun. 2021 Apr 30;551:100-106.