Biography

• Dr. Hong Li obtained her Ph.D. degree from Shanghai Jiao Tong University in 2011 and is currently a Professor of State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute. Her major research interests are molecular mechanisms of hypoxia driven HCC progression and finding new uses in cancer for existing drugs. As a principal investigator, she has gotten 4 projects funded by National Natural Science Foundation of China, 1 Shanghai Municipal Health System Outstanding Academic Leaders Foundation Program, 2 grant from Natural Science Foundation of Shanghai, etc. She has authored or co-authored more than 40 papers in international famous magazines and 4 applied patents.

Publications

1. Tengfei Liu, Junming Yu, Chao Ge, Fangyu Zhao, Jing Chen, Chunxiao Miao, Wenjiao Jin, Qingqing Zhou, Qin Geng, Hechun Lin, Hua Tian, Taoyang Chen, Haiyang Xie, Ying Cui, Ming Yao, Xiuying Xiao, Jinjun Li, Hong Li*. Sperm associated antigen 4 promotes SREBP1-mediated de novo lipogenesis via interaction with lamin A/C and contributes to tumor progression in hepatocellular carcinoma, Cancer Lett., 536:215642 (2022)

2. Lili Zhang, Qi Huo, Chao Ge, Fangyu Zhao, Qingqing Zhou, Xiaoxia Chen, Hua Tian, Taoyang Chen, Haiyang Xie, Ying Cui, Ming Yao, Hong Li*, Jinjun Li*. ZNF143-mediated H3K9 trimethylation upregulates CDC6 by activating MDIG in hepatocellular carcinoma, Cancer Res., 80(12): 2599-2611 (2020).

3. Zhen Song, Tengfei Liu, Jing Chen, Chao Ge, Fangyu Zhao, Miaoxin Zhu, Taoyang Chen, Ying Cui, Hua Tian, Ming Yao, Jinjun Li, Hong Li*. HIF-1α-induced RIT1 promotes liver cancer growth and metastasis and its deficiency increases sensitivity to sorafenib, Cancer Lett., 28;460:96-107 (2019).

4. Hechun Lin, Jing Li, Dongdong Cheng, Xiao Zhang, Tao Yu, Fangyu Zhao, Qing Geng, Miaoxin Zhu, Hanwei Kong, Hong Li*, Ming Yao*. Nuclear export protein CSE1L interacts with P65 and promotes NSCLC growth via NF-κB/MAPK pathway. Mol Ther Oncolytics, 10;21:23-36 (2021).

5. Dantong Sun, Yan Zhu, Han Zhao, Tiantian Bian, Tianjun Li, Kewei Liu, Lizong Feng, Hong Li*, Helei Hou*. Loss of ARID1A expression promotes lung adenocarcinoma metastasis and predicts a poor prognosis. Cell Oncol (Dordr). 44(5):1019-1034 (2021).

6. Dantong Sun, Lu Tian, Yan Zhu, Yang Wo, Qiaoling Liu, Shihai Liu, Hong Li*, Helei Hou*. Subunits of ARID1 serve as novel biomarkers for the sensitivity to immune checkpoint inhibitors and prognosis of advanced non-small cell lung cancer. Mol Med. 13;26(1):78 (2020).

7. Tengfei Liu, Junming Yu, Chao Ge, Fangyu Zhao, Chunxiao Miao, Wenjiao Jin, Yang Su, Qin Geng, Taoyang Chen, Haiyang Xie, Ying Cui, Ming Yao, Jinjun Li, Helei Hou*, Hong Li*. B-Cell Receptor-Associated Protein 31 Promotes Metastasis via AKT/β-Catenin/Snail Pathway in Hepatocellular Carcinoma. Front Mol Biosci. 11;8:656151 (2021).

8. Lin Gao, Chao Ge, Tao Fang, Fangyu Zhao, Taoyang Chen, Ming Yao, Jinjun Li, Hong Li*. ANGPTL2 promotes tumor metastasis in hepatocellular carcinoma. J Gastroenterol Hepatol, 30(2):396-404 (2015).

9. Hong Li, Chao Ge, Fangyu Zhao, Mingxia Yan, Chen Hu, Deshui Jia, Hua Tian, Miaoxin Zhu, Taoyang Chen, Guoping Jiang, Haiyang Xie, Ying Cui, Jianren Gu, Hong Tu, Xianghuo He, Ming Yao, Yongzhong Liu, Jinjun Li*. Hypoxia-inducible factor 1 alpha-activated angiopoietin-like protein 4 contributes to tumor metastasis via vascular cell adhesion molecule-1/integrin beta1 signaling in human hepatocellular carcinoma. Hepatology, 54(3):910-919 (2011).