Biography

• He received his PhD from the Institute of Genetics and Developmental Biology, Chinese Academy of Sciences in 2003, then worked as a postdoctoral researcher at the Institute of Biochemistry, Faculty of Medicine, University of Cologne, Germany from 2003 to 2009.In October 2009, he joined Shanghai Cancer Institute as a talent introduction, and is currently the leader of the neurotransmitter and tumor microenvironment research group.

• His researches has been supported by the National Natural Science Foundation of China for key projects, major research projects, general projects, the 12th Five-Year Plan Period, the National High Technology Research and Development Program (863 Program), the Shanghai Municipal Education Commission Research and Innovation Program, and the Shanghai Jiao Tong University Medical-Industrial Crossover Research Fund, etc. He has published more than 60 SCI papers as corresponding author in international journals such as Gastroenterology, Gut, Hepatology, Journal of Hepatology, Clincal Cancer Research, Cancer Research, Oncogene, etc. He is the president of Matrix Biology Committee of Chinese Physiological Society and vice chairman of Cancer Metabolism and Therapy Committee of Precision Medicine Committee of Chinese Medical Doctor Association. He is an outstanding leader of Shanghai, as well as an outstanding leader of Shanghai Health System. He has applied for 9 national invention patents, obtained 6 national patent authorizations and 1 international PCT patent authorization. He was awarded the second prize of Shanghai Medical Science and Technology as first author.

Publications

1. Wang X, Hu LP, Qin WT, Yang Q, Chen DY, Li Q, Zhou KX, Huang PQ, Xu CJ, Li J, Yao LL, Wang YH, Tian GA, Yang JY, Yang MW, Liu DJ, Sun YW, Jiang SH, Zhang XL, Zhang ZG*. Identification of a subset of immunosuppressive P2RX1-negative neutrophils in pancreatic cancer liver metastasis. Nature Communications, 2021 Jan 8; 12(1):174. (Corresponding author)

2. 2)Nie HZ, Huang PQ, Jiang SH, Yang Q, Hu LP, Yang XM, Li J, Wang YH, Li Q, Zhang YF, Zhu L, Zhang YL, Yu YQ, Xiao GG, Sun YW, Ji JG, Zhang ZG*. The short isoform of PRLR suppresses the pentose phosphate pathway and nucleotide synthesis through the NEK9-Hippo axis in pancreatic cancer.  Theranostics, 2021 Feb 6;11(8):3898-3915. (Corresponding author)

3. Zhang N, Sundquist J, Sundquist K, Zhang ZG*, Ji J. Combined Use of Aspirin and Selective Serotonin Reuptake Inhibitors Is Associated With Lower Risk of Colorectal Cancer: A Nested Case-Control Study. Am J Gastroenterol. 2021 Feb 26. (Corresponding author)

4. Jiang SH, Hu LP, Wang X, Li J, Zhang ZG*. Neurotransmitters: emerging targets in cancer. Oncogene. 2020 Jan;39(3):503-515. (Corresponding author)

5. Jiang SH, Zhu LL, Zhang M, Li RK, Yang Q, Yan JY, Zhang C, Yang JY, Dong FY, Dai M, Hu LP, Li J, Li Q, Wang YH, Yang XM, Zhang YL, Nie HZ, Zhu L, Zhang XL, Tian GA, Zhang XX, Cao XY, Tao LY, Huang S, Jiang YS, Hua R, Luo KQ, Gu JR, Sun YW, Hou SW, Zhang ZG*. GABRP regulates chemokine signaling, macrophage recruitment, and tumor progression in pancreatic cancer through tuning KCNN4-mediated Ca2+ signaling in a GABA-independent manner. Gut, 2019 Nov;68(11):1994-2006. (Corresponding author)

6. Hu LP, Zhang XX, Jiang SH, Tao LY, Li Q, Zhu LL, Yang MW, Huo YM, Jiang YS, Tian GA, Cao XY, Zhang YL, Yang Q, Yang XM, Wang YH, Li J, Xiao GG, Sun YW, Zhang ZG*. Targeting Purinergic Receptor P2Y2 prevents the growth of pancreatic ductal adenocarcinoma by inhibiting cancer cell glycolysis. Clin Cancer Res, 2019 Feb 15;25(4):1318-1330. (Corresponding author)

7. Yang XM, Cao XY, He P, Li J, Feng MX, Zhang YL, Zhang XL, Wang YH, Yang Q, Zhu L, Nie HZ, Jiang SH, Tian GA, Zhang XX, Liu Q, Ji J, Zhu X, Xia Q, Zhang ZG*. Overexpression of Rac GTPase activating Protein 1 Contributes to Proliferation of Cancer Cells by Reducing Hippo Signaling to Promote Cytokinesis. Gastroenterology, 2018 Oct;155(4):1233-1249. (Corresponding author)

8. Zhang YL, Li Q, Yang XM, Fang F, Li J, Wang YH, Yang Q, Zhu L, Nie HZ, Zhang XL, Feng MX, Jiang SH, Tian GA, Hu LP, Lee HY, Lee SJ, Xia Q, Zhang ZG*, SPON2 Promotes M1-like Macrophage Recruitment and Inhibits Hepatocellular Carcinoma Metastasis by Distinct Integrin-Rho GTPase-Hippo Pathways. Cancer Research, 2018 May 1;78(9):2305-2317. (Corresponding author, Highlight)

9. Jiang SH, Li J, Dong FY, Yang JY, Liu DJ, Yang XM, Wang YH, Yang MW, Fu XL, Zhang XX, Li Q, Pang XF, Huo YM, Li J, Zhang JF, Lee HY, Lee SJ, Qin WX, Gu JR, Sun YW, Zhang ZG*. Increased Serotonin Signaling Contributes to the Warburg Effect in Pancreatic Tumor Cells under Metabolic Stress and Promotes Growth of Pancreatic Tumors in Mice. Gastroenterology, 2017 Jul;153(1):277-291. (Corresponding author)

10. Nie H, Li J, Yang XM, Cao QZ, Feng MX, Xue F, Wei L, Qin W, Gu J, Xia Q, Zhang ZG*. Mineralocorticoid receptor suppresses cancer progression and Warburg effect by modulating miR-338-3p-PKLR axis in hepatocellular carcinoma. Hepatology, 2015 Oct;62(4):1145-59. (Corresponding author)

11. Li J, Yang XM, Wang YH, Feng MX, Liu XJ, Zhang YL, Huang S, Wu Z, Xue F, Qin WX, Gu JR, Xia Q, Zhang ZG*. Monoamine oxidase A suppresses Hepatocellular Carcinoma metastasis by inhibiting the adrenergic system and its transactivation of EGFR signaling. Journal of Hepatology, 2014 Jun;60(6):1225-34. (Corresponding author)

12. Zhao SJ, Jiang YQ, Xu NW, Li Q, Zhang Q, Wang SY, Li J, Wang YH, Zhang YL, Jiang SH, Wang YJ, Huang YJ, Zhang XX, Tian GA, Zhang CC, Lv YY, Dai M, Liu F, Zhang R, Zhou D, Zhang ZG*. SPARCL1 suppresses osteosarcoma metastasis and recruits M1 macrophages by autocrine activation of canonical WNT/β-catenin signaling through stabilization of the WNT-receptor complex. Oncogene, 2018 Feb 22;37(8):1049-1061 (Corresponding author)

13. Li Q, Zhu CC, Ni B, Zhang ZZ, Jiang SH, Hu LP, Wang X, Zhang XX, Huang PQ, Yang Q, Li J, Gu JR, Xu J, Luo KQ, Zhao G, Zhang ZG*. Lysyl oxidase promotes liver metastasis of gastric cancer via facilitating the reciprocal interactions between tumor cells and cancer associated fibroblasts. EBioMedicine. 2019 Nov; 49:157-171. (Corresponding author)

14. Li J, Wang YH, Ma MZ, Jiang SH, Zhang XL, Zhang YL, Yang XM, Xu CJ, Tian GA, Li Q, Wang Y, Zhu L, Nie HZ, Feng MX, Xia Q, Gu JR, Xu Q, Zhang ZG*. Autocrine CTHRC1 activates hepatic stellate cells and promotes liver fibrosis by activating TGF-β signaling. EBioMedicine. 2019 Feb; 40:43-55. (Corresponding author)

15. Yang MW, Tao LY, Jiang YS, Yang JY, Huo YM, Liu DJ, Li J, Fu XL, He R, Lin C, Liu W, Zhang JF, Hua R, Li Q, Jiang SH, Hu LP, Tian GA, Zhang XX, Niu N, Lu P, Shi J, Xiao GG, Wang LW, Xue J*, Zhang ZG*, Sun YW*. Perineural Invasion Reprograms the Immune Microenvironment through Cholinergic Signaling in Pancreatic Ductal Adenocarcinoma. Cancer Res. 2020, 80, 1991-2003. (Co- Corresponding author)

16. Zhou Y, Liu F, Xu QY, Yang BK, Li X, Jiang SH, Hu LP, Zhang XL, Zhu LL, Li Q, Zhu X, Shao HF, Dai M, Shen YF, Ni Bo, Wang S, Zhang ZG*, Teng YC*. Inhibiting Importin 4-mediated nuclear import of CEBPD enhances chemosensitivity by repression of PRKDC-driven DNA damage repair in cervical cancer. Oncogene. 2020 Aug;39(34):5633-5648. (Co- Corresponding author)

17. Liu F, Dai M, Xu QY, Zhu X, Zhou Y, Jiang SH, Wang YH, Ai ZH, Ma L, Zhang YL, Hu LP, Yang Q, Li J, Zhao SJ, Zhang ZG*, Teng YC*. SRSF10-mediated IL1RAP alternative splicing regulates cervical cancer oncogenesis via mIL1RAP-NF-κB-CD47 axis. Oncogene. 2018 May;37(18):2394-2409. (Co- Corresponding author)

18. Xu QY, Ge QL, Zhou Y, Yang BK, Yang Q, Jiang SH, Jiang RZ, Ai ZH, Zhang ZG*, Teng YC*. MELK promotes Endometrial carcinoma progression via activating mTOR signaling pathway. EBioMedicine. 2020 Jan;51:102609. (Co- Corresponding author)