Biography

• Duan Yourong received her doctor's degree in June 2002 at the National Biomaterial Engineering Research Center of Sichuan University. From June 2002 to May 2004, She worked in the post doctoral mobile station of the School of Pharmacy of West China Medical University. In May 2004, She joined the State Key Laboratory of Polymer Materials, School of Materials, Donghua University; In 2005, She was transferred to the State Key Laboratory of Oncogenes and Related Genes of Shanghai Cancer Research Institute. Duan Yourong has a multidisciplinary research background and is engaged in the research of drug carriers. She is committed to technological development in the field of biomaterials and translational medicine. Focusing on the key scientific issues of tumor drug resistance, she has explored and developed a variety of new strategies to overcome tumor drug resistance based on nanotechnology and biomaterials. In recent years, She has published more than 100 papers. 20 Chinese invention patents were authorized, 4 of which were successfully transferred to the company.

Publications

1. Jiali Zhang, Qianqian Guo, Dai Dai, Jian Yu, Liting Wang , Zhihua Wu , Huihua Ding , Nan Shen , Yourong Duan.Rapamycin-encapsulated costimulatory ICOS/CD40L-bispecific nanoparticles restrict pathogenic helper T-B-cell interactions while in situ suppressing mTOR for lupus treatment. Biomaterials 2022,121766

2. Qianqian Guo , Chuanrong Chen , Zhihua Wu , Wei Zhang , Liting Wang , Jian Yu , Longxia Li  , Jiali Zhang , Yourong Duan. Engineered PD-1/TIGIT dual-activating cell-membrane nanoparticles with dexamethasone act synergistically to shape the effector T cell/Treg balance and alleviate systemic lupus erythematosus. Biomaterials, 2022.285:121517

3. Quan Wang#, Hongshu Jing#, Jun Lin, Zhihua Wu, Yu Tian, Ke Gong, Qianqian Guo, Xupeng Yang, Liting Wang, Zhaojun Li*, Yourong Duan*, Programmed prodrug breaking the feedback regulation of P-selectin in plaque inflammation for atherosclerotic therapy. Biomaterials, 2022. 288: 121705.

4. Chuanrong Chen#, Qianqian Guo#, Hao Fu, Jian Yu, Liting wang, Ying Sun, Jiali Zhang*, Yourong Duan*.Asynchronous blockade of PD-L1 and CD155 by polymeric nanoparticles inhibits triple-negative breast cancer progression and metastasis. Biomaterials. 2021,275:120988.

5. Wang Quan#; Tian Yu#; Liu Lei#; Chen Chuanrong; Zhang Wei; Wang Liting; Guo Qianqian; Ding Li; Fu Hao; Song Hongjiang*; Shi Junyu*; Duan Yourong*; Precise Targeting Therapy of Orthotopic Gastric Carcinoma by siRNA and Chemotherapeutic Drug Codelivered in pH-Sensitive Nano Platform., Advanced Healthcare Materials, 2021,(20)10：2100966

6. Chen, Chuanrong#; Shen, Ming#; Liao, Hongze*; Guo, Qianqian; Fu, Hao; Yu, Jian*; Duan, Yourong*; A paclitaxel and microRNA-124 coloaded stepped cleavable nanosystem against triple negative breast cancer. Journal of Nanobiotechnology, 2021,(55)19

7. Gong Ke#; Jiao Juyang#; Xu Chaoqun; Dong Yang; Li Dongxiao; He Di; Zhao De; Yu Jian; Sun Ying; Zhang Wei*;Bai Min*; Duan Yourong*; The targetable nanoparticle BAF312@cRGD-CaP-NP represses tumor growth and angiogenesis by downregulating the S1PR1/P-STAT3/VEGFA axis in triple-negative breast cancer, Journal of Nanobiotechnology,2021, (165)19

8. Guo Qianqian#; Dong Yang; Zhang Yanhua; Fu Hao; Chen Chuanrong; Wang Liting; Yang Xupeng; Shen Ming; Yu Jian; Chen Meiwan*; Zhang Jiali*; Duan Yourong*; Sequential Release of Pooled siRNAs and Paclitaxel by Aptamer-Functionalized Shell-Core Nanoparticles to Overcome Paclitaxel Resistance of Prostate Cancer. ACS Applied Materials & Interfaces, 2021,(12)13 13990–1400

9. Wang, Qi#; He, Yang; Shen, Ming; Huang, Lili; Ding, Li; Hu, Jian; Dong, Yang; Fu, Hao; Wang, Quan; Sun,Ying; Zhang, Lin*; Cao, Jun*; Duan, Yourong*; Precision Embolism: Biocompatible Temperature-Sensitive Hydrogels as Novel Embolic Materials for Both Mainstream and Peripheral Vessels, Advanced Functional Materials, 2021,(20)31：2011170

10. Zhao, De#; Wu, Zhihua; Zhang, Wei; Yu, Jian; Li, He*; Di, Wen*; Duan, Yourong*; Substrate-Induced Growth of Micro/Nanostructured Zn(OH)F Arrays for Highly Sensitive Microfluidic Fluorescence Assays., ACS Appl Mater Interfaces, 2021,(24)13：28462-28471

11. Liting Wang#, Qing Shen#, Hongze Liao*, Hao Fu, Qi Wang, Jian Yu, Wei Zhang, Chuanrong Chen, Yang Dong, Xupeng Yang, Qianqian Guo, Jiali Zhang, Jian Zhang, Wei Zhang, Houwen Lin*, Yourong Duan*.Multi-Arm PEG/Peptidomimetic Conjugate Inhibitors of DR6/APP Interaction Block Hematogenous Tumor Cell Extravasation. Adv Sci. 2021,(11)8:2003558

12. Zhang Jiali*, Chen Chuanrong*, Fu Hao, Yu Jian, Sun Yin, Huang Hui, Tang yanjia#, Shen Nan#, Duan Yourong#.MicroRNA-125a-Loaded Polymeric Nanoparticles Alleviate Systemic Lupus Erythematosus by Restoring Effector/Regulatory T Cells Balance. ACS Nano. 2020, 28;14(4):4414-4429.

13. Zhao De*,Wu Zhihua*,Yu Jian, Wang Hongzhi ,Li Yaogang#,Duan Yourong #. Highly sensitive microfluidic detection of carcinoembryonic antigen via a synergetic fluorescence enhancement strategy based on the micro/nanostructure optimization of ZnO nanorod arrays and in situ ZIF-8 coating. Chemical Engineering Journal.2020, 383: 123230