Ottawa-Shanghai Joint School of Medicine

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SHEN Jun

MD & Ph.D

Chief Physician & Associate Professor

Email: shenjun@vip.163.com

Tel: +86 21 58752345

Research highlight: inflammatory bowel diseases, mucosal barrier, microbiota

Summary

  • Jun Shen MD, PhD. Chief Physician at the department of gastroenterology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, & Associate Professor of Gastroenterology at Shanghai Jiaotong University. Since 2009, he is the management core of the IBD unit at the department of gastroenterology, Renji Hospital and one of the founders of Shanghai Inflammatory Bowel Disease Research Center, with research focus on clinical and translational researches in IBD.

  • He is classified in the top-ranking scientist in IBD in China contributing so far to more than 80 peer-reviewed full papers.

  • Besides these academic activities, Jun Shen is the members of almost all Chinese IBD Organizations.

PUBLICATIONS:

  • Refereed Chapters in Books:

  1. Shen Jun, Ran Zhihua. Diagnostic and therapeutic dilemma in Inflammatory Bowel Disease [Chinese](Science Press, 2015) pp. 3-11; pp170-180

  • Papers in refereed Journals:

  1. Cai C, Zhu S, Tong J, Wang T, Feng Q, Qiao Y, Shen J. Relating the transcriptome and microbiome by paired terminal ileal Crohn disease. iScience. 2021 May 5;24(6):102516.

  2. Chen Y, Shen J. Mucosal immunity and tRNA, tRF, and tiRNA. J Mol Med (Berl). 2021 Jan;99(1):47-56.

  3. Lyu Y, Zhou Y, Shen J. An Overview of Tissue-Resident Memory T Cells in the Intestine: From Physiological Functions to Pathological Mechanisms. Front Immunol. 2022 May 31;13:912393.

  4. Yueying C, Jing F, Tian Y, Yuqi Q, Jun S. Bioelectrical impedance analysis-based nomogram construction for predicting secondary loss of response to infliximab in bio-naïve Crohn's disease patients. Biomed Pharmacother. 2021 Oct;142:112076.

  5. Chen Y, Li H, Feng J, Suo S, Feng Q, Shen J. A Novel Radiomics Nomogram for the Prediction of Secondary Loss of Response to Infliximab in Crohn's Disease. J Inflamm Res. 2021 Jun 24;14:2731-2740.

  6. Chen Y, Li H, Feng Q, Shen J. Development and Validation of an Interleukin-6 Nomogram to Predict Primary Non-response to Infliximab in Crohn's Disease Patients. Front Pharmacol. 2021 Apr 14;12:654985.

  7. Guo C, Shen J. Cytoskeletal Organization and Cell Polarity in the Pathogenesis of Crohn's Disease. Clin Rev Allergy Immunol. 2021 Apr;60(2):164-174.

  8. Yang E, Shen J. The roles and functions of Paneth cells in Crohn's disease: A critical review. Cell Prolif. 2021 Jan;54(1):e12958.

  9. Mao R, Liang J, Shen J, Ghosh S, Zhu LR, Yang H, Wu KC, Chen MH; Chinese Society of IBD, Chinese Elite IBD Union; Chinese IBD Quality Care Evaluation Center Committee. Lancet Gastroenterol Hepatol. Implications of COVID-19 for patients with pre-existing digestive diseases. 2020 May;5(5):425-427.

  10. Chen Y, Shen J. Core indicators of an evaluation and guidance system for quality of care in inflammatory bowel disease centers: A critical review. EClinicalMedicine. 2022 Apr 7;46:101382.

  11. Xu Y, Shen J, Ran Z. Emerging views of mitophagy in immunity and autoimmune diseases. Autophagy. 2019 Apr 5:1-15.

  12. Qiao YQ, Cai CW, Shen J, Zheng Q, Ran ZH. Circular RNA expression alterations in colon tissues of Crohn's disease patients. Mol Med Rep. 2019 May; 19 (5):4500-4506.

  13. Zhang Y, Chen D, Wang F, Li X, Xue X, Jiang M, Xu B, Chu Y, Wang W, Wu K, Mao R, Shen J, Yang S, Liang J. Comparison of the efficiency of different enemas on patients with distal ulcerative colitis. Cell Prolif. 2019 Mar; 52 (2):e12559.

  14. Jiang H, Shen J, Ran Z. Epithelial-mesenchymal transition in Crohn's disease. Mucosal Immunol. 2018 Mar; 11 (2):294-303.

  15. Cui YD, Shen J. The effect of immunomodulator on the operation of inflammatory bowel disease and the strategy of perioperative withdrawal. Chin J Inflamm Bowel Dis. 2018 Oct; 2(4): 267-269. Chinese

  16. Qian X, Wang T, Shen J, Ran Z. Low dose of azathioprine is effective to induce and maintain remission in active Crohn disease: A prospective observational study. Medicine (Baltimore). 2018 Aug;97(34):e11814.

  17. Hanyang L, Xuanzhe L, Xuyang C, Yujia Q, Jiarong F, Jun S, Zhihua R. Application of Zebrafish Models in Inflammatory Bowel Disease. Front Immunol. 2017 May 3;8:501.

  18. Jin S, Zhao D, Cai C, Song D, Shen J, Xu A, Qiao Y, Ran Z, Zheng Q. Low-dose penicillin exposure in early life decreases Th17 and the susceptibility to DSS colitis in mice through gut microbiota modification. Sci Rep. 2017 Mar 8;7:43662.

  19. Zhao D, Cai C, Zheng Q, Jin S, Song D, Shen J, Ran Z. Vancomycin pre-treatment impairs tissue healing in experimental colitis: Importance of innate lymphoid cells. Biochem Biophys Res Commun. 2017 Jan 29;483(1):237-244.

  20. Li X, Shen J, Ran Z. Crosstalk between the gut and the liver via susceptibility loci: Novel advances in inflammatory bowel disease and autoimmune liver disease. Clin Immunol. 2017 Feb;175:115-123.

  21. Zhou Y, Shen J, Ran ZH. Research progress of new oral biological agents in the treatment of inflammatory bowel disease. Chin J Gastroentero1. 2017; 22 (8): 498-501.Chinese

  22. Zhao ZJ, Shen J. Circular RNA participates in the carcinogenesis and the malignant behavior of cancer. RNA Biol. 2017 May 4;14(5):514-521.

  23. Lu JT, Xu AT, Shen J, Ran ZH. Crosstalk between intestinal epithelial cell and adaptive immune cell in intestinal mucosal immunity. J Gastroenterol Hepatol. 2017 May;32(5):975-980.

  24. Peng JC, Feng Q, Zhu J, Shen J, Qiao YQ, Xu JR, Ran ZH. Usefulness of spectral computed tomography for evaluation of intestinal activity and severity in ileocolonic Crohn's disease. Therap Adv Gastroenterol. 2016 Nov;9(6):795-805.

  25. Qian XX, Peng JC, Xu AT, Zhao D, Qiao YQ, Wang TR, Shen J, Ran ZH. Noncoding Transcribed Ultraconserved Region (T-UCR) uc.261 Participates in Intestinal Mucosa Barrier Damage in Crohn's Disease. Inflamm Bowel Dis. 2016 Dec;22(12):2840-2852.

  26. Zhao D, Xu A, Dai Z, Peng J, Zhu M, Shen J, Zheng Q, Ran Z. WNT5A transforms intestinal CD8αα⁺ IELs into an unconventional phenotype with pro-inflammatory features. BMC Gastroenterol. 2015 Dec 10;15:173.

  27. Shen J, Mao AP, Zhu MM, Zhao P, Xu JJ, Zuo Z. Ulcerative Colitis Database: An Integrated Database and Toolkit for Gene Function and Medication Involved in Ulcerative Colitis. Inflamm Bowel Dis. 2015; 21: 1872-82.

  28. Mao AP, Shen J, Zuo Z. Expression and regulation of long noncoding RNAs in TLR4 signaling in mouse macrophages. BMC Genomics. 2015;16:45.

  29. Peng JC, Shen J, Zhu Q, Ran ZH. The impact of Clostridum difficile on surgical rate among ulcerative colitis patients: A systemic review and meta-analysis. Saudi J Gastroenterol. 2015 Jul-Aug;21(4):208-12.

  30. Qiao YQ, Huang ML, Zheng Q, Wang TR, Xu AT, Cao Y, Zhao D, Ran ZH, Shen J*. CNTNAP3 associated ATG16L1 expression and Crohn's disease. Mediators Inflamm. 2015; 2015: 404185.

  31. Qi F, Jun S, Qi QY, Chen PJ, Chuan GX, Jiong Z, Rong XJ. Utility of the diffusion-weighted imaging for activity evaluation in Crohn's disease patients underwent magnetic resonance enterography. BMC Gastroenterol. 2015; 15: 12.

  32. Wang TR, Peng JC, Qiao YQ, Zhu MM, Zhao D, Shen J*, Ran ZH. Helicobacter pylori regulates TLR4 and TLR9 during gastric carcinogenesis. Int J Clin Exp Pathol. 2014; 7: 6950-5.

  33. Mao AP, Shen J, Zuo Z. Expression and regulation of long noncoding RNAs in TLR4 signaling in mouse macrophages. BMC Genomics. 2015; 16: 45.

  34. Peng JC, Ran ZH, Shen J*. Seasonal variation in onset and relapse of IBD and a model to predict the frequency of onset, relapse, and severity of IBD based on artificial neural network. Int J Colorectal Dis. 2015; 30: 1267-73.

  35. Xu J, Lin H, Feng X, Tang M, Shen J*, Ran Z. Different therapeutic approaches on quality of life in patients with inflammatory bowel disease. BMC Gastroenterol. 2014; 14: 199.

  36. Shen J, Zuo ZX, Mao AP. Effect of probiotics on inducing remission and maintaining therapy in ulcerative colitis, Crohn's disease, and pouchitis: meta-analysis of randomized controlled trials. Inflamm Bowel Dis. 2014; 20: 21-35.

  37. Shen J, Qiao YQ, Ran ZH, Wang TR. Up-regulation and Pre-activation of TRAF3 and TRAF5 in Inflammatory Bowel Disease. Int J Med Sci. 2013; 10: 156-163.

  38. Shen J, Qiao YQ, Ran ZH, Wang TR. Different Activation of TRAF4 and TRAF6 in Inflammatory Bowel Disease. Mediators Inflamm. 2013;2013: 647936.

  39. Shen J, Qiao Y, Ran Z, Wang T, Xu J, Feng J. Intestinal protein expression profile identifies inflammatory bowel disease and predicts relapse. Int J Clin Exp Pathol. 2013; 6: 917-925.

  40. Qiao YQ, Huang ML, Xu AT, Zhao D, Ran ZH, Shen J*. LncRNA DQ786243 affects Treg related CREB and Foxp3 expression in Crohn's disease. J Biomed Sci. 2013 Dec 1;20:87.

  41. Xu J, Tang M, Shen J*. Trends and Factors Affecting Hospitalization Costs in Patients with Inflammatory Bowel Disease: A Two-Center Study over the Past Decade. Gastroenterol Res Pract. 2013;2013:267630

  42. Shen J, Ran ZH, Tong JL, Xiao SD. Meta-analysis: The utility and safety of heparin in the treatment of active ulcerative colitis. Aliment Pharmacol Ther. 2007; 26:653-663.

  43. Shen J, Ran ZH, Zhang Y, Cai Q, Yin HM, Zhou XT, Xiao SD. Biomarkers of altered coagulation and fibrinolysis as measures of disease activity in active inflammatory bowel disease: A gender-stratified, cohort analysis. Thromb Res. 2009; 123: 604-611.

  44. Shen Jun, Ran Zhi Hua, Yin Hong Min, Zhou Xiao Tian, Xiao Shu Dong. Meta-analysis: the effect and adverse events of Lactobacilli versus placebo in maintenance therapy for Crohn's disease. Intern Med J. 2009; 39: 103-109.

  45. Shen Jun, Ran Zhi Hua, Tong Jin Lu, Chen Xiang, Xiao Shu Dong. Are endoscopic grading and scoring systems in inflammatory bowel disease the same? Saudi Medical Journal. 2008; 29: 1432-1437.

  46. Shen Jun, Qian Xiaoxian, Ran Zhihua, Tong Jinlu, Qiao Yuqi and Huang Meilan. Activated expression of CD27-CD70 co-stimulatory molecules in inflamed and non-inflamed tissues of intestinal mucosa in patients with inflammatory bowel disease. Sci Res Essays. 2011; 6: 793–798.

  47. Xu AT, Li Y, Zhao D, Shen J, Xu XT, Qiao YQ, Zhu MM, Wang TR, Cui Y, Ai LY, Ran ZH. High suppressor of cytokine signaling-3 expression impairs STAT3-dependent protective effects of interleukin-22 in ulcerative colitis in remission. Inflamm Bowel Dis. 2015; 21: 241-50.

  48. Tong JL, Feng Q, Shen J, Qiao YQ, Zheng Q, Gu Y, Chen XY, Li XB, Dai J, Hua J, Xu JR, Ran ZH. Computed tomography enterography versus balloon-assisted enteroscopy for evaluation of small bowel lesions in Crohn's disease. J Gastroenterol Hepatol. 2013; 28: 1180-1186.

  49. Peng JC, Shen J, Ran ZH. Transcribed ultraconserved region in human cancers. RNA Biol. 2013; 10: 1771-1777.

  50. 50.Qiao YQ, Shen J, Gu Y, Tong JL, Xu XT, Huang ML, Ran ZH. Gene expression of tumor necrosis factor receptor associated-factor (TRAF)-1 and TRAF-2 in inflammatory bowel disease. J Dig Dis. 2013; 14: 244-250.

  51. Huang ML, Xu XT, Shen J, Qiao YQ, Dai ZH, Ran ZH. Prevalence and factors related to hepatitis B and C infection in inflammatory bowel disease patients in China: A retrospective study. J Crohns Colitis. 2013. pii: S1873-9946(13)00310-3.

  52. adalimumab in Crohn's disease: meta-analysis of placebo-controlled trials. J Dig Dis. 2011; 12: 165-172.

  53. Tong JL, Ran ZH, Shen J, Fan GQ, Xiao SD. Association between fecal bile acids and colorectal cancer: a meta-analysis of observational studies. Yonsei Med J 2008; 49: 792-803.

  54. Nie F, Shen J, Tong JL, Xu XT, Zhu MM, Ran ZH. Meta-analysis: the efficacy and safety of monoclonal antibody targeted to epidermal growth factor receptor in the treatment of patients with metastatic colorectal cancer. J Dig Dis. 2009; 10: 247-257.

  55. Tong JL, Ran ZH, Shen J, Xiao SD. Sequential therapy vs. standard triple therapies for Helicobacter pylori infection: a meta-analysis. J Clin Pharm Ther. 2009; 34: 41-53.

  56. Tong JL, Ran ZH, Shen J, Zhang CX, Xiao SD. Meta-analysis: the effect of supplementation with probiotics on eradication rates and adverse events during Helicobacter pylori eradication therapy. Aliment Pharmacol Ther. 2007; 25: 155-168.

  57. Shen Jun, Qiao Yuqi, Ran Zhihua, Tong Jinlu, Zhu Mingming, Wang Tianrong, Huang Meilan. [Different expression of cysteine-aspartic acid protease-3 in patients with inflammatory bowel disease]. Chinese Journal of Clinical Gastroenterology. 2012; 24: 195-197. Chinese

  58. Shen Jun, Qiao Yuqi, Ran Zhihua, Tong Jinlu, Zhu Mingming, Wang Tianrong, Huang Meilan. [Expression and clinical significance of Obestatin and Ghrelin in patients with inflammatory bowel disease. ]Chinese Journal of Gastroenterology and Hepatology. 2012; 21: 1073-1076. Chinese

  59. Shen Jun, Qiao Yuqi, Ran Zhihua, Tong Jinlu, Zhu Mingming, Wang Tianrong, Huang Meilan. [Research on diagnostic value of Presenilin 1 to differentiate ulcerative colitis from Crohn’s disease]. Chinese Journal of Clinical Research. 2012; 26; 2054-2056. Chinese

  60. Shen Jun, Qiao Yuqi, Ran Zhihua, Tong Jinlu, Zhu Mingming, Wang Tianrong, Huang Meilan. [High expression of Wnt9b and its significance in patients with ulcerative colitis]. Modern Digestion & Intervention. 2012; 17: 208-211. Chinese

  61. Shen Jun, Ran Zhihua, Huang Meilan, Wang Tianrong, Qian Xiaoxian, Zhang Feng, Qiao Yuqi. [TRAF5 expression in peripheral blood in patients with inflammatory bowel disease and its correlation with endoscopic disease activity]. Chinese Journal of Clinical Gastroenterology. 2011; 23: 84-86. Chinese

  62. Shen Jun, Ran Zhihua, Tong Jinlu, Huang Meilan, Wang Tianrong. [Plasma TRAF3 expression in patients with inflammatory bowel disease]. Modern Digestion & Intervention. 2010; 15: 195-198. Chinese

  63. Shen Jun, Qian Xiaoxian, Ran Zhihua, Tong Jinlu, Xu Xitao, Qiao Yuqi, Huang Meilan. [Activated expression of CD27 in patients with inflammatory bowel disease.] Chinese Journal of Gastroenterology and Hepatology. 2010; 19: 842-845. Chinese

  64. Shen Jun, Ran Zhi-hua, Zheng Qing, Tong Jin-lu, Cai Qing, Zhu Ming-ming, Huang Mei-lan, Wang Tian-rong. [Study on activation of CD40-CD154 co-stimulatory pathway and its correlation with endoscopic disease activity in patients with inflammatory bowel disease]. Chinese Journal of Digestive Endoscopy. 2010; 27: 80-84. Chinese

  65. Shen Jun, Ran Zhihua, Nie Fang, Tong Jinlu, Zhu Mingming, Cai Qing, Huang Meilan, Wang Tianrong. [Plasma levels of TRAF1 in patients with inflammatory bowel disease and its clinical significance]. Chinese Journal of Gastroenterology and Hepatology. 2009; 18: 896-899. Chinese

  66. Shen Jun, Ran Zhihua, Tong Jinlu, Cai Qing, Huang Meilan, Wang Tianrong. [Correlation of plasma TRAF2 levels and endoscopic disease activity in patients with inflammatory bowel disease].Chinese Journal of Clinical Research 2010; 27: 212-214. Chinese

  67. Shen Jun, Ran Zhihua, Tong Jinlu, Cai Qing, Huang Meilan, Wang Tianrong, Qian Xiaoxian, Zhang Feng. [Elevated plasma tumor necrosis factor receptor-associated factor-4 in patients with inflammatory bowel disease]. Journal of New Medicine. 2010; 20: 12-15. Chinese

  68. Shen Jun, Ran Zhihua, Tong Jinlu, Nie Fang, Cai Qing, Huang Meilan, Wang Tianrong, Qian Xiaoxian, Zhang Feng. [Activation of TRAF6 in peripheral blood mononuclear cells and plasma in patients with inflammatory bowel disease]. Chinese Journal of Clinical Gastroenterology. 2009; 21: 259-262. Chinese

  69. Shen Jun, Ran Zhihua, Tong Jinlu, Xiao Shudong. [Effect of probiotics on remission, relapse and pouchitis in inflammatory bowel disease: meta-analysis of randomised controlled trials]. Chinese Journal of Gastroenterology and Hepatology. 2008; 17: 114-118. Chinese

  70. Shen Jun, Ran Zhi-hua, Tong Jin-lu, Xiao Shu-dong. [System review of the utility of heparin in the treatment of ulcerative colitis]. Chinese Journal of Gastroenterology. 2007; 12: 685-690. Chinese

  71. Shen Jun, Ran Zhihua, Tong Jinlu, Xiao Shudong. [Effect and adverse events of Lactobacilli in maintenance therapy for Crohn's disease: meta-analysis of randomized controlled trials]. Chinese Journal of Clinical Gastroenterology. 2008; 20:16-21. Chinese

  72. Shen Jun, Zhou Xiaotian, Ran Zhihua, Zhang Yao, Yin Hongmin, Cai Qing, Huang Meilan, Xiao Shudong. [Influence of altered coagulation and fibrinolysis status on disease activity of inflammatory bowel disease]. Chinese Journal of Gastroenterology and Hepatology. 2008; 21: 305-308. Chinese

  73. Shen Jun, Cai Qing, Ran Zhi-hua, Zhang Yao, Zhou Xiaotian, Yin Hongmin, Xiao Shudong. [Altered protein and lipid metabolism in patients with active inflammatory bowel disease]. Chinese Journal of Digestion. 2008; 28: 318-322. Chinese

  74. Shen Jun, Ran Zhi-hua,Tong Jinlu, Chen Xiang, Xiao Shudong. [Study on the concodence of endoscopic grading and scoring systems in inflammatory bowel disease]. Chinese Journal of Digestive Endoscopy. 2008; 25: 239-244. Chinese

  75. Shen Jun, Yin Hongmin, Ran Zhi-hua, Zhou Xiao-tian, Zhang Yao, Cai Qing. [Altered coagulation and fibrinolysis status in Chinese patients with active inflammatory bowel disease and their associations with disease activity]. Chinese Journal of Clinical Gastroenterology. 2009; 21: 18-20. Chinese

  76. Shen Jun, Zhu Qi, Yuan Yaozong, Zhang Zhongwei, Chen Kemin. [Alterations in focal encephalic function in patients of irritable bowel syndrome]. Chinese Journal of Gastroenterology and Hepatology. 2005; 14: 167-171. Chinese

  77. Shen Jun, Zhu Qi, Yuan Yaozong, Zhang Zhongwei, Chen Kemin. [Effect of Changji' an Oral Liquid on Activated Signal Alterative Intensity in Algesthesia Domain in Patients with Diarrhea Type Irritable Bowel Syndrome due to Gan-Pi Disharmony].Chinese Journal of Integrated Traditional and Western Medicine. 2005; 11: 967-969. Chinese

  78. Shen Jun, Zhu Qi, Yuan Yaozong, Zhang Zhongwei, Chen Kemin. [Effect of Changji'an oral liquid on stimulated functional area of brain in patients of irritable bowel syndrome with diarrhea of disharmony between liver and spleen]. Chinese Jounral of Integrated Traditional and Western Medicine on Digestion. 2005; 4: 11-15. Chinese

  79. Shen Jun, Zhu Qi, Yuan Yaozong, Fu Hua, Feng Guowei. [Changes of plasma brain-gut peptides levels in patients with irritable bowel syndrome]. Chinese Journal of Gastroenterology. 2005; 10: 290-292. Chinese

  80. Shen Jun, Zhu Qi. [Role of brain-gut peptides in irritable bowel syndrome]. Foreign Medical Sciences (Section of Digestive Disease). 2004; 24: 169-171. Chinese