Biography

• Professor Yuanjin Xu, doctoral supervisor and chief physician of Department of Oral Surgery, Shanghai Ninth People’s Hospital affiliated to Shanghai Jiao Tong University School of Medicine. She is the distinguished lecture of Ottawa-Shanghai Joint School of Medicine and the lecture of the curriculum Oral Anatomy and Physiology towards undergraduates. She was also the visiting scholar of Osaka Dental University and Tufts University School of Dental Medicine.

• She serves concurrently as editor of the textbook Oral Anatomy and Physiology which projected by National Health Commission of the People’s Republic of China. Besides, she is the executive member of China Medicinal Biotechnology Association-3D Printing Professional Committee and Chinese Association of Plastics and Aesthetics- Digital and Precision Medicine Branch. Additionally, she is also the member of China Medicinal Biotechnology Association- Biomaterial Group.

• Her research focuses on regeneration of oral and maxillofacial bone and cartilage, fabrication of biological scaffold materials applied in repair of oral and maxillofacial osteochondral defects together with their mechanisms, as well as effects of traditional Chinese medicine including quercetin and icariin on osteogenesis and chondrogenesis of mesenchymal stem cells.

• In recent years, she has published a series of original articles in academic journals including Biomaterials. The contents of these articles covered the in vivo and in vitro research of polyphenols, construction of scaffold materials, fabrication of drug delivery system and establishment of animal models of bone and cartilage defect.

• As the project leader, she has successfully applied and taken charge of more than 10 scientific projects funded by the National Natural Science Foundation of China or Shanghai Science and Technology Committee. She has been honored the third prize of Shanghai Science and Technology Progress Award as one of the major participants. Besides, as one of the major inventors, she has been authorized 7 patents for invention.

• As an oral and maxillofacial surgeon, professor Xu is always devoted herself to the diagnosis and treatment of oral and maxillofacial diseases, especially in minimally invasive extraction of complicated impacted teeth and supernumerary teeth, as well as the treatment of jaw benign lesion.

Publications

1. Yuning Zhou#, Yue Hu#, Mamoru Uemura, Lunguo Xia*, Xinge Yu*, Yuanjin Xu*. The fabrication and the effect of strontium-substituted calcium silicate/silk fibroin on bone regeneration in vitro and in vivo. Bioengineering and Biotechnology. 2022, doi:10.3389/fbioe.2022.842530.

2. Zhipeng Gui#, Yue Hu#, Yuning Zhou, Kaili Lin*, Yuanjin Xu*. Effect of quercetin on chondrocyte phenotype and extracellular matrix expression. Chinese Journal of Natural Medicines. 2022, 18(12):922-933.

3. Yue Hu#, Zhipeng Gui#, Yuning Zhou, Lunguo Xia*, Kaili Lin*, Yuanjin Xu*. Quercetin alleviates rat osteoarthritis by inhibiting inflammation and apoptosis of chondrocytes, modulating synovial macrophages polarization to M2 macrophages. Free Radical Biology and Medicine, 2019, 145: 146-160.

4. Lunguo Xia, Wudi Ma, Yuning Zhou, Zhipeng Gui, Aihua Yao, Deping Wang, Akimichi Takemura, Mamoru Uemura, Kailin Lin*, Yuanjin Xu*. Stimulatory Effects of Boron Containing Bioactive Glass on Osteogenesis and Angiogenesis of Polycaprolactone: In Vitro Study. BioMed Research International. 2019, doi:10.1155/2019/8961409.

5. Wenjun Sun#, Yuning Zhou#, Xinran Zhang, Wei Xia,Yuanjin Xu*, Kaili Lin*. Injectable nano-structured silicon-containing hydroxyapatite microspheres with enhanced osteogenic differentiation and angiogenic factor expression. Ceramics International. 2018, 44(16): 20457-20464.

6. Zhipeng Gui, Yuning Zhou, Yue Hu, Lunguo Xia, Yuanjin Xu. Effect of quercetin on angiogenesis and its molecular mechanism in human umbilical vein endothelial cells. China Journal of Oral and Maxillofacial Surgery. 2018, 16(5):385-390.

7. Yuning Zhou, Yuqiong Wu, Wudi Ma, Xinquan Jiang, Akimichi Takemra, Mamoru Uemura, Lunguo Xia*, Kaili Lin*, Yuanjin Xu*. The effect of quercetin delivery system on osteogenesis and angiogenesis under osteoporotic conditions. Journal of Materials Chemistry B. 2017,5(3): 612-625.

• Yuning Zhou, Wudi Ma, Zhipeng Gui, Lunguo Xia, Yuanjin Xu. Osteogenesis ability of bone marrow-derived mesenchymal stem cells derived from diabetic rabbits. China Journal of Oral and Maxillofacial Surgery, 2017, 15 (2): 103-108.