Research direction： clinical and basic research on parenteral nutrition-associated liver disease; Neonatal parenteral nutrition support; clinical and basic research on short bowel syndrome
Wang Ying, chief physician and doctoral supervisor, is currently the director of the division of pediatric gastroenterology and nutrition, Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine. She graduated from the Shanghai Jiao Tong University School of Medicine in 2012 with Ph.D. in pediatrics. From 2014 to 2015, she served as a visiting scholar at the University of North Carolina. From 2015 to 2016, she participated in the Global Scholars Research Training Program of Harvard Medical School and achieved excellent scores. Five scientific projects were granted, including two National Natural Science Foundations of China, and three provincial and ministerial scientific research funds. In 2017, she was sponsored by Shanghai Pujiang Program. She has won the second prize in the National Science and Technology Progress Award, the first prize in the Shanghai Science and Technology Progress Award, the Song Qingling pediatric medicine Award, and so on. She published 30 SCI papers as the first author or corresponding author.
Current academic position: Member of Group of Gastroenterology, Chinese Pediatric Society, Chinese Medical Association; Member of Group of Youth, Parenteral and Enteral Nutrition Society, Chinese Medical Association; Member of Group of Gastroenterology , Hepatology and Nutrition, Parenteral and Enteral Nutrition Society, Chinese Medical Association；Member of Group of Pediatrics, Parenteral and Enteral Nutrition Society, Chinese Medical Association; Member of Group of Pediatric Gastroenterology, Pediatrician Society, Chinese Medical Doctor Association；Deputy leader of Group of Gastroenterology, Pediatric Society, Shanghai Medical Association; Member and Secretary of Parenteral and Enteral Nutrition Society, Shanghai Medical Association; Standing committee member of Pediatric Nutrition, Chinese Maternal and Child Health Association; Member of Medical Food and Nutrition Support Branch, Chinese Nutrition Society；Member of Children's Health and Drug Research Committee of China Traditional Chinese Medicine Association.
Wang Y#, Tao YX, Cai W, Tang QY, Feng Y, Wu J. Protective effect of parenteral glutamine supplementation on hepatic function in very low birth weight infants. Clin Nutr. 2010;29(3):307-311.
Wang Y#, Cai W, Tao YX, Tang QY, Feng Y, Wu J. Glutamine supplementation in preterm infants receiving parenteral nutrition leads to an early improvement in liver function. Asia Pac J Clin Nutr. 2013;22(4):530-536.
Yan W#, Wang Y#, Xiao Y, et al. Palmitate induces TRB3 expression and promotes apoptosis in human liver cells. Cell Physiol Biochem. 2014;33(3):823-834.
Wang Y#, Zhou KJ, Tang QY, Hong L, Feng Y, Lu LN, Wang WP, Cai W. Effect of an Olive Oil-Based Lipid Emulsion Compared With a Soybean Oil-Based Lipid Emulsion on Liver Chemistry and Bile Acid Composition in Preterm Infants Receiving Parenteral Nutrition: A Double-Blind, Randomized Trial. JPEN J Parenter Enteral Nutr. 2016 Aug;40(6):842-50.
Wang Y#, Feng Y, Lu LN, Wang WP, He ZJ, Xie LJ, Hong L, Tang QY, Cai W. The effects of different lipid emulsions on the lipid profile, fatty acid composition, and antioxidant capacity of preterm infants: A double-blind, randomized clinical trial. Clin Nutr. 2016 Oct;35(5):1023-31.
Yan W#, Hong L#, Wang Y#, Feng Y, Lu L, Tao Y, Wu J, Ruan H, Tang Q, Cai W. Retrospective Dual-Center Study of Parenteral Nutrition-Associated Cholestasis in Premature Neonates: 15 Years' Experience. Nutr Clin Pract. 2017 Jun;32(3):407-413.
Huang J, Yu Q, Wen J, Yan W, Lu L, Tao Y, Cai W, Wang Y*. Peripherally inserted central catheter-related complications in infants with intestinal failure. Asia Pac J Clin Nutr. 2018;27(6):1225-1229.
Zhang T, Wang N, Yan W, Lu L, Tao Y, Li F, Wang Y*, Cai W*. Effect of a fish oil-based lipid emulsion on intestinal failure-associated liver disease in children. Eur J Clin Nutr. 2018 Oct;72(10):1364-1372.
Xiao Y, Zhou K, Lu Y, Yan W, Cai W*, Wang Y*. Administration of antibiotics contributes to cholestasis in pediatric patients with intestinal failure via the alteration of FXR signaling. Exp Mol Med. 2018 Nov 30;50(12):1-14.
Yan JK, Zhang T, Dai LN, Gu BL, Zhu J, Yan WH, Cai W*, Wang Y*. CELF1/p53 axis: a sustained antiproliferative signal leading to villus atrophy under total parenteral nutrition. FASEB J. 2019 Mar;33(3):3378-3391.
Zhang T#, Wang Y#, Yan W, Lu L, Tao Y, Jia J, Cai W. Microbial alteration of small bowel stoma effluents and colonic feces in infants with short bowel syndrome. J Pediatr Surg. 2020 Jul;55(7):1366-1372.
Wang N, Yan W, Hong L, Lu L, Feng Y, Wu J, Tao Y, Ruan H, Tang Q, Cai W, Wang Y*. Risk factors of parenteral nutrition-associated cholestasis in very-low-birthweight infants. J Paediatr Child Health. 2020 Nov;56(11):1785-1790
Feng H, Zhang T, Yan W, Lu L, Tao Y, Cai W, Wang Y*. Micronutrient deficiencies in pediatric short bowel syndrome: a 10-year review from an intestinal rehabilitation center in China. Pediatr Surg Int. 2020 Dec;36(12):1481-1487
Wei Z, Lu L, Zheng Y, Yan W, Tao Y, Xiao Y, Cai W*, Wang Y*. Variants in the Enteric Smooth Muscle Actin γ-2 Cause Pediatric Intestinal Pseudo-obstruction in Chinese Patients. J Pediatr Gastroenterol Nutr. 2021 Jan 1;72(1):36-42.
Wang N, Wang J, Zhang T, Huang L, Yan W, Lu L, Jia J, Tao Y, Cai W*, Wang Y*. Alterations of gut microbiota and serum bile acids are associated with parenteral nutrition-associated liver disease. J Pediatr Surg. 2021 Apr;56(4):738-744.
Tian X#, Wang Y#, Lu Y, Wang W, Du J, Chen S, Zhou H, Cai W, Xiao Y. Conditional depletion of macrophages ameliorates cholestatic liver injury and fibrosis via lncRNA-H19. Cell Death Dis. 2021 Jun 24;12(7):646.
Wang Y#, Chen S, Yan W, Lu L, Tao Y, Xiao Y, Cai W. Congenital Short-Bowel Syndrome: Clinical and Genetic Presentation in China. JPEN J Parenter Enteral Nutr. 2021 Jul;45(5):1009-1015
Wang Y#, Li Z, Wu JL, Zhang L, Liu M, Tan M, Botma A, Liu M, Mulder KA, Abrahamse-Berkeveld M, Cai W. A partially hydrolyzed formula with synbiotics supports adequate growth and is well tolerated in healthy, Chinese term infants: A double-blind, randomized controlled trial. Nutrition. 2021 Nov-Dec;91-92:111472.
Xiao Y#, Wang Y#, Liu Y#, Wang W, Tian X, Chen S, Lu Y, Du J, Cai W. A nonbile acid farnesoid X receptor agonist tropifexor potently inhibits cholestatic liver injury and fibrosis by modulating the gut-liver axis. Liver Int. 2021 Sep;41(9):2117-2131
Yan W, Xiao Y, Zhang Y, Tao Y, Cao Y, Liu K, Cai W*, Wang Y*. Monogenic mutations in four cases of neonatal-onset watery diarrhea and a mutation review in East Asia. Orphanet J Rare Dis. 2021 Sep 9;16(1):383
Xiao Y, Sun Y, Lu Y, Du J, Tian X, Cai W*, Wang Y*. Loss function of Bcr mutation causes gastrointestinal dysmotility and brain developmental defects. Neurogastroenterol Motil. 2021 Dec;33(12):e14190
Chen S, Xiao Y, Liu Y, Tian X, Wang W, Jiang L, Wu W, Zhang T, Cai W*, Wang Y*. Fish oil-based lipid emulsion alleviates parenteral nutrition-associated liver diseases and intestinal injury in piglets. JPEN J Parenter Enteral Nutr. 2022 Mar;46(3):709-720.
Liu K, Lu L, Chen S, Gu B, Cai H, Wang Y*, Cai W*. Loss-of-function variants within LMOD1 actin-binding site 2 cause pediatric intestinal pseudo-obstruction by impairing protein stability and actin nucleation. FASEB J. 2022 Mar;36(3):e22194.
Cao Y, Yan WH, Lu LN, Tao YJ, Feng HX, Wu QQ, Chu YJ, Cai W*, Wang Y*. Catheter-related bloodstream infections in children with intestinal failure: a 6-year review from an intestinal rehabilitation center in China. World J Pediatr. 2022 Apr;18(4):271-277.
Wang J, Yan W, Lu L, Tao Y, Huang L, Cai W*, Wang Y*. Intestinal Continuity Alleviates Pediatric Intestinal Failure-Associated Liver Disease. Front Surg. 2022 May 16;9:881782
Wu Q#, Wang Y#, Wang W, Zhang Y, Yan W, Lu L, Tao Y, Tang Q. Efficacy and safety of parenteral nutrition with iron sucrose for anemia prevention in preterm infants: A randomized, double-blind controlled study. Asia Pac J Clin Nutr. 2022;31(2):222-228
Wang Y#, Liu Y#, Gao B, Yan J, Cai W, Jiang L. Untargeted Metabolomics Reveal Parenteral Nutrition-Associated Alterations in Pediatric Patients with Short Bowel Syndrome. Metabolites. 2022 Jun 27;12(7):600
Zhu J#, Wang Y#, Wang W#, Wu B, Lu Y, Du J, Cai W, Xiao Y. Mptx2 defends against peritoneal infection by methicillin-resistant staphylococcus aureus. Int Immunopharmacol. 2022 Jul;108:108856.
Jiang L, Wang N, Cheng S, Liu Y, Chen S, Wang Y*, Cai W*. RNA-sequencing identifies novel transcriptomic signatures in intestinal failure-associated liver disease. J Pediatr Surg. 2022 Sep;57(9):158-165
Wang W#, Wang Y#, Liu Y, Tian X, Chen S, Lu Y, Wu B, Xiao Y, Cai W. Lactobacillus plantarum supplementation alleviates liver and intestinal injury in parenteral nutrition-fed piglets. JPEN J Parenter Enteral Nutr. 2022 Jun 22. doi: 10.1002/jpen.2429. Epub ahead of print.