研究方向包括：

1. 感染与自身免疫病   

   实验室主要关注一种特殊的左手螺旋核酸—Z型核酸，已知病毒感染可以导致Z型核酸的产生，在肠炎、皮炎等自身免疫疾病中发现内源的Z型核酸可以诱导炎症反应。

   我们想要探索的科学问题包括：

   1.1 Z型核酸在抗感染免疫中的功能

   1.2 Z型核酸在疾病中的功能及调控

   1.3 其他特殊构象核酸的生理学功能

2. 抗肿瘤免疫

        探索干细胞技术在肿瘤免疫治疗中的应用。

科研项目：

1.   国家自然科学基金 面上项目 (2023) 32370918

2.  上海市公卫优青项目 (2023) GWVI-11.2-YQ45

3.  上海交通大学医学院/上海市免疫所PI启动经费 (2023)

1. Qiannan Tang; Rachel E. Rigby; George R. Young; Astrid Korning Hvidt; Tanja Davis; Tiong Kit Tan; Anne Bridgeman; Alain R. Townsend; George Kassiotis; Jan Rehwinkel; Adenosine-to-inosine editing of endogenous Z-form RNA by the deaminase ADAR1 prevents spontaneous MAVS- dependent type I interferon responses, Immunity, 2021, 54(9): 1961-1975.e5

2. Qiannan Tang; Xinlu Wang; Guangxia Gao; The Short Form of the Zinc Finger Antiviral Protein Inhibits Influenza A Virus Protein Expression and Is Antagonized by the Virus-Encoded NS1, Journal of Virology, 2017, 2(91): e01909-16

3. Qiannan Tang; Z-nucleic acids: Uncovering the functions from past to present, European Journal of Immunology, 2022, 52(11): 1700-1711

4. Le Qin; Yuanbin Cui; Tingjie Yuan; Dongmei Chen; Ruocong Zhao; Shanglin Li; Zhiwu Jiang; Qiting Wu; Youguo Long; Suna Wang; Zhaoyang Tang; Huixia Pan; Xiaoping Li; Wei Wei; Jie Yang; Xuequn Luo; Zhenfeng Zhang; Qiannan Tang; Pentao Liu; Robert Weinkove; Yao Yao; Dajiang Qin; Jean Paul Thiery; Peng Li; Co-expression of a PD-L1-specific chimeric switch receptor augments the efficacy and persistence of CAR T cells via the CD70-CD27 axis, Nature Communications, 2022, 13(1): 6051

5. Shanglin Li; Ruocong Zhao; Diwei Zheng; Le Qin; Yuanbin Cui; Yao Li; Zhiwu Jiang; Mengjun Zhong; Jingxuan Shi; Ming Li; Xindong Wang; Zhaoyang Tang; Qiting Wu; Youguo Long; Duo Hu; Suna Wang; Yao Yao; Shuang Liu; Li-Hua Yang; Zhenfeng Zhang; Qiannan Tang; Pentao Liu; Yangqiu Li; Peng Li; DAP10 integration in CAR-T cells enhances the killing of heterogeneous tumors by harnessing endogenous NKG2D, Molecular Therapy - Oncolytics, 2022, 26: 15-26

             6. Yuanbin Cui, Tingjie Yuan,Ying Wang, Di Diwei Zheng, Le Qin, Shanglin Li, Zhiwu Jiang, Shouheng Lin, Wenjing Guo, Zhaoduan Liang, Yi Li, Yao Yao, Xingguo Liu, Qiannan Tang, Hai-Yan Tu, Xu-Chao Zhang, Zhaoyang Tang, Yan-Lai Tang, Libin Huang, Xuequn Luo, Nathalie Wong, Zhenfeng Zhang, Dajiang Qin, Jean Paul Thiery, Kailin Xu, Peng Li. T lymphocytes expressing the switchable chimeric Fc receptor CD64 exhibit augmented persistence and antitumor activity. Cell Reports, 2023, Jul25; 42(7):112797.

实验室地址：上海市黄浦区重庆南路280号 上海交通大学医学院西五楼 10楼

邮箱：qiannan.tang@sjtu.edu.cn

电话：021-54591053