1） 抗体应答的转录调控机制

抗体应答是体液免疫反应的核心环节之一，其异常会导致免疫功能低下、自身免疫性疾病或B细胞肿瘤。我们利用小鼠遗传学模型、流式细胞分析等免疫学手段、谱系追踪以及高通量二代测序，深入研究：抗体应答反应过程中关键免疫细胞分化的转录和表观遗传学机制；免疫记忆形成、维持和召回的转录机制；以及自身免疫状态下的抗体应答失调机制。

2） B细胞和抗体介导的抗肿瘤免疫

肿瘤微环境中存在B细胞，并和T细胞等形成异位淋巴组织。B细胞通过分泌抗体、细胞因子和抗原递呈等功能，在肿瘤免疫和免疫治疗中发挥重要作用。我们利用临床结肠癌标本和动物模型，采用单细胞多组学技术、抗体表达和谱系追踪等，深入研究：肠癌中异位淋巴组织形成的机制及功能；B细胞和浆细胞在肠癌中克隆演化过程；鉴定肠癌中促癌和抗癌的抗体

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2. Zhu L, Zhang H, Hu Q, Zhang M, Zhang W, Huang C (黄传新)*. Bach2 antagonizes leukotriene B4-Ltb4r1-JunB signaling to constrain Tfh13 cell differentiation. Cell Rep. 2026 Apr 7;45(4):117220.

3. Yu Y, Ma J, Zhou M, Gu X, Zhou Y, Li Z, Zhang T, Gong W, Huang C (黄传新)*, Xiang J*. NUDT21-mediated Alternative Polyadenylation of CDK19 Reprograms Cholesterol Biosynthesis to Drive Colorectal Cancer Progression. Adv Sci (Weinh). 2026 Feb;13(7):e18346.

4. Xu T, Zhang T, Xu C, Yang F, Zhang W, Huang C (黄传新)*. Notch2 signaling governs activated B cells to form memory B cells. Cell Rep. 2024 Jul 9;43(7):114454

5. Xu C, Zhang T, Wang H, Zhu H, Huang C (黄传新)*, Pan M*; Integrative single-cell analysis reveals distinct adaptive immune signatures in the cutaneous lesions of pemphigus. Journal of Autoimmunity, 2024, 142:103128-103139

6. Hu Q, Xu T, Zhang M, Zhang H, Liu Y, Li HB, Chen C, Zheng J, Zhang Z, Li F, Shen N, Zhang W, Melnick A*, Huang C (黄传新)*. Diverging regulation of Bach2 protein and RNA expression determine cell fate in early B cell response. Cell Rep. 2022 Jul 5;40(1):111035.

7. Chen X, Xu Y, Chen Q, Zhang H, Zeng Y, Geng Y, Shen L, Li F, Chen L, Chen GQ, Huang C (黄传新)*, Liu J*. The phosphatase PTEN links platelets with immune regulatory functions of mouse T follicular helper cells. Nat Commun. 2022 May 19;13(1):2762

8. Zhang H, Dai D, Hu Q, Yang F, Xue Y, Li F, Shen N, Zhang M*, Huang C (黄传新)*. Bach2 attenuates IL-2R signaling to control Treg homeostasis and Tfr development. Cell Rep. 2021 May 11;35(6):109096.