目前已知RNA上含有100余种化学修饰，其中m6A, m1A, m5C, pseudoUridine, APA是RNA上最主要的几种化学修饰。课题组团队在m6A领域已经做出了系列原创性研究，积累了扎实的学术基础和构建了坚实的实验平台。目前m6A的研究已经成为了一个热点领域，但是大家对于其它类型的RNA修饰关注不是很多，特别是不同的RNA修饰之间如何协调应对外界不同类型的刺激从而协同调控RNA的水平和功能鲜有研究。免疫细胞以及相应的生理病理条件下的免疫反应为研究这一重大前沿问题提供了一个非常好的模型和角度。我们目前的初步研究成果表明各种不同的RNA修饰在T细胞激活的过程中发挥着关键的主动的动态作用，而且这些修饰之间存在着功能上的相互作用和协调。

在接下来的研究中将在以下几个方面开展工作：

（1） m1A RNA 表观遗传修饰在免疫细胞中的功能以及分子机制；

（2） pseudoUridine在免疫细胞中的功能以及其作用的分子机制；

（3） APA在免疫细胞中的功能以及其作用的分子机制；

（4） 开发这些RNA修饰的干预策略应用于肿瘤和炎症的临床前免疫治疗；

（5）不同RNA修饰类型之间的协同作用及其规律。

There are more than 100 types of different chemical RNA modification, among which m6A, m1A, m5C, pseudoUridine and APA are the major ones. HBL lab has made a series of pioneering discoveries in the m6A studies, won international reputations in the field, and laid solid experimental foundation. m6A research has been the frontier of the epigenetics field, but it is under explored for other types of RNA modifications, especially the cross-talks among those RNA modifications in response to environmental stimulation are unknown. Immune cells, especially T cells and macrophages in various inflammatory disease and tumor, provide an ideal perspective to explore this frontier. Combine mouse reverse genetics and state-of-art omics techniques, our research focuses on the following areas:

(1)  Function of m1A modification in T cells and macrophages;

(2)  Function of pseudoUridine modification in T cells and macrophages;

(3)  Function of APA modification in T cells and macrophages;

(4)  Develop inhibitors to those RNA modification and apply to tumor immunotherapy;

(5)  Cross-talks of those RNA modifications.

实验室主页：
https://huabingli.wixsite.com/lilab

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