王锋-上海市免疫学研究所

2016-至今，研究员，课题组组长（PI），上海市免疫学研究所，上海交通大学医学院

2010-2016，博士后，斯坦福大学医学院，合作导师: Mark M. Davis

2005-2010，博士研究生，北京生命科学研究所，合作导师: 邓兴旺

2001-2005，生物学，学士，北京师范大学

本实验室主要研究T细胞的抗原识别，信号转导和功能调节机制，以及抗原特异性T细胞在肿瘤等重大疾病的作用。我们将综合应用免疫学、分子细胞、生物化学和计算生物学等多种技术手段在以下三个方向进行探索：（1）T细胞信号、功能和TCR组库在肿瘤和自身免疫疾病中的作用；（2）代谢产物调控免疫系统的分子机制和功能；（3）T细胞免疫治疗的基础和临床转化研究。

项目编号	项目类型	项目名称	起止年月	备注
82541045	国家自然科学基金专项项目	基于功能免疫受体组库与临床影像组学的肺结节人工智能诊断模型构建	2026/01-2028/12	项目负责人
82230055	国家自然科学基金重点项目	T细胞抗原识别调节肠道免疫耐受和炎症机制	2023/01-2027/12	项目负责人
SQ2022YFA090022-1	科技部国家重点研发计划	实体瘤响应工程免疫细胞的设计合成与应用	2023/01-2027/12	子课题负责人
82101879	国家自然科学基金青年项目	天然小分子化合物Lawsone在多发性硬化症中的作用及机制探究	2022/01-2024/12	项目负责人（杨翠霞）
2021YFC2502300	科技部国家重点研发计划青年科学家项目（青年973计划）	TCR-T治疗急性髓系白血病新方法的研发	2021/12-2024/11	项目骨干（罗凌杰）
NA	国家万人计划青年拔尖人才	免疫细胞识别和信号的代谢调节机制	2021/12-2023/12	项目负责人
82003013	国家自然科学基金青年项目	致癌病毒和驱动突变肿瘤新抗原及靶向TCR的筛选和验证研究	2021/01-2023/12	项目负责人（罗凌杰）
82003011	国家自然科学基金青年项目	天然代谢产物伊维菌素对T细胞抗肿瘤效应的影响及作用机制研究	2021/01-2023/12	项目负责人（王秦兰）
82071852	国家自然科学基金面上项目	免疫检查点阻断条件下共生菌对Treg细胞功能和肠道炎症反应的调节机制	2021/01-2024/12	项目负责人
20410713800	上海市科学技术委员会国际合作项目	新型冠状病毒抗原T细胞免疫识别及受体组库动态研究	2020/10-2023/09	项目负责人
SQ2018YFA090045-01	科技部国家重点基础研究发展计划(973计划)	重要病原体疫苗的人工合成	2019/07-2024/06	骨干参与
18JC1414100	上海市科学技术委员会基础研究重点项目	基于T细胞受体和免疫检查点基因编辑的抗肿瘤免疫策略	2018/07-2021/06	项目负责人
81701553	国家自然科学基金青年项目	硫酸胆固醇对T细胞受体信号的调控机制	2018/01-2020/12	项目负责人（蚁瑞荣）
1710000163	上海市教委高校特聘教授	基于代谢产物的免疫调节机制	2017/09-2020/08	项目负责人
KJ3-0214-16-0133	上海交通大学医学院院基金	基于代谢产物的免疫调节机制研究	2016/11-2022/10	项目负责人
17PJ1408400	上海市科学技术委员会浦江人才计划	胆固醇代谢的免疫调节	2017/07-2019/06	项目负责人
81771739	国家自然科学基金面上项目	硫酸胆固醇在实验性自身免疫性脑脊髓炎中的作用机制	2018/01-2021/12	项目负责人

1. Huang K, Li X, Liang W, Wu S, Ye Y, Lu Y, Zheng J, Wang W, Zheng Q, Fu G, Gao S, Wang F#. PTMA safeguards mitochondrial integrity to sustain metabolic function and antitumor activity of CD8 T Cells. Science Immunology, 2026 Jan 23;11(115):eadz7275. doi: 10.1126/sciimmunol.adz7275.

2. Li X, Liang W, Wang W, Sherman E, Huang K, Wang F#. The TCR-SUB1-DOCK2 signaling axis governs autoimmunity by regulating CD4+ T cell migratory capacity. Immunity, 2025. Epub 2025 Dec 9. doi: 10.1016/j.immuni.2025.11.009.

3. Liang W, Liang Y, Yu M, Ji C, Wang F#. TCR signaling-enhancing mutation alters lipid metabolism of thymocytes and impairs anti-tumor immunity of mature T cells. PNAS, 2025 Oct 21;122(42):e2507154122. doi: 10.1073/pnas.2507154122.

4. Qu Y, Liang W, Yu M, Wang C, Luo M, Zhong L, Li Z, Wang F#. MYO1F in neutrophils is required for the response to immune checkpoint blockade therapy. Journal of Experimental Medicine. 2025 Jun 2;222(6):e20241957. doi: 10.1084/jem.20241957.

5. Wang Y, Li R, Tong R, Chen T, Sun M, Luo L, Li Z, Chen Y, Zhao Y, Zhang C, Wei L, Lin W, Chen H, Qian K, Chen AF, Liu J, Chen L, Li B, Wang F, Wang L, Su B, Pu J#. Integrating single-cell RNA and T cell/B cell receptor sequencing with mass cytometry reveals dynamic trajectories of human peripheral immune cells from birth to old age. Nature Immunology. 2025 Feb;26(2):308-322. doi: 10.1038/s41590-024-02059-6. Epub 2025 Jan 29. PMID: 39881000; PMCID: PMC11785523.

6. Yang C, Ma Y, Lu Q, Qu Y, Li Y, Cheng S, Xiao C, Chen J, Wang C, Wang F, Xiang AP, Huang W, Tang X, Zheng H. 2-Bromo-1,4-Naphthalenedione promotes CD8+ T cell expansion and limits Th1/Th17 to mitigate experimental autoimmune encephalomyelitis. Journal of Neuroinflammation. 2024 Jul 27;21(1):181. doi: 10.1186/s12974-024-03172-x. PMID: 39068463; PMCID: PMC11283727.

7. Zhang M, Xu W, Luo L, Guan F, Wang X, Zhu P, Zhang J, Zhou X#, Wang F#, Ye S#. Identification and affinity enhancement of T-cell receptor targeting a KRASG12V cancer neoantigen. Communications Biology, 2024 Apr 29;7(1):512. doi: 10.1038/s42003-024-06209-2.

8. Deng S, Zhang Y, Wang H, Liang W, Xie L, Li N, Fang Y, Wang Y, Liu J, Chi H, Sun Y, Ye R, Shan L, Shi J, Zan Shen Z, Wang Y, Wang S, Brosseau J, Wang F, Liu G, Quan Y, Xu J. ITPRIPL1 binds CD3ε to impede T cell activation and enable tumor immune evasion. Cell, 2024 Apr 5:S0092-8674(24)00310-6. doi: 10.1016/j.cell.2024.03.019.

9. Liu Z, Zhang Y, Ma N, Yang Y, Ma Y, Wang F, Wang Y, Wei J, Chen H, Tartarone A, Velotta JB, Dayyani F, Gabriel E, Wakefield CJ, Kidane B, Carbonelli C, Long L, Liu Z, Su J, Li Z. Progenitor-like exhausted SPRY1+CD8+ T cells potentiate responsiveness to neoadjuvant PD-1 blockade in esophageal squamous cell carcinoma. Cancer Cell, 2023 Oct 7:S1535-6108(23)00327-6. doi: 10.1016/j.ccell.2023.09.011.

10. Wang Y, Liu Y, Wang Y, Wu Y, Chen Z, Wang F#, Wan X#, Wang F#, Sun X. Macrophage Sult2b1 promotes pathological neovascularization in age-related macular degeneration. Life Science Alliance, 2023; 7;6(11):e202302020. doi: 10.26508/lsa.202302020.

11. Tong R, Luo L, Zhao Y, Sun M, Li R, Zhong J, Chen Y, Hu L, Li Z, Shi J, Lyu Y, Hu L, Guo X, Liu Q, Shuang T, Zhang C, Yuan A, Sun L, Zhang Z, Qian K, Chen L, Lin W, Chen A, Wang F#, Pu J#. Characterizing the cellular and molecular variabilities of peripheral immune cells in healthy recipients of BBIBP-CorV inactivated SARS-CoV-2 vaccine by single-cell RNA sequencing. Emerging Microbes & Infections, 2023; 12(1):e2187245. doi: 10.1080/22221751.2023.2187245.

12. Miao N, Wang Z, Wang Q, Xie H, Yang N, Wang Y, Wang J, Kang H, Bai W, Wang Y, He R, Yan K, Wang Y, Hu Q, Liu Z, Li F, Wang F, Ginhoux F, Zhang X, Yin J, Lu L, Wang J. Oxidized mitochondrial DNA induces gasdermin D oligomerization in systemic lupus erythematosus. Nature Communications, 2023; 14(1):872. doi: 10.1038/s41467-023-36522-z.

13. Zhao X, Xu M, Zhao Z, Wang Y, Liu Y, Zhang T, Wan X, Jiang M, Luo X, Shen Y, Chen L, Zhou M, Wang F#, Sun X#. Bifidobacterium promotes retinal ganglion cell survival by regulating the balance of retinal glial cells. CNS Neuroscience and Therapeutics, 2023; 29(Suppl. 1):146–160. doi: 10.1111/cns.14165.

14. Liang W, Yi R, Wang W, Shi Y, Zhang J, Xu X, Wang Q, Liu M, Wang F#. Enhancing the antitumor immunity of T cells by engineering the lipid-regulatory site of the TCR/CD3 complex. Cancer Immunology Research, 2023; 11(1):93-108. doi: 10.1158/2326-6066. CIR-21-1118.

15. Wang Q, Zhu T, Miao N, Qu Y, Wang Z, Chao Y, Wang J, Wu W, Xu X, Xu C, Xia L, Wang F#. Disulfiram bolsters T cell anti-tumor immunity through direct activation of LCK-mediated TCR signaling. EMBO Journal, 2022; e110636. doi: 10.15252/embj.2022110636.

16. Zhao X, Liang W, Wang Y, Yi R, Luo L, Wang W, Sun N, Yu M, Xu W, Sheng Q, Lu L, Pang J, Lv Z#, Wang F#. Ontogeny of RORγt+ cells in the intestine of newborns and its role in the development of experimental necrotizing enterocolitis. Cell & Bioscience, 2022.

17. Wang Y, Jin H, Wang Y, Yao Y, Yang C, Meng J, Tan X, Nie Y, Xue L, Xu B, Zhao H, Wang F#. Sult2b1 deficiency exacerbates ischemic stroke by promoting pro-inflammatory macrophage polarization in mice. Theranostics, 2021; 11(20):10074-10090. doi:10.7150/thno.61646.

18. Luo L, Liang W, Pang J, Xu G, Chen Y, Guo X, Wang X, Zhao Y, Lai Y, Liu Y, Li B, Su B, Zhang S, Baniyash M, Shen L, Chen L, Ling Y, Wang Y, Liang Q, Lu H, Zhang Z, Wang F#. Dynamics of TCR repertoire and T cell function in COVID-19 convalescent individuals. Cell Discovery, 2021，28;7(1):89. doi: 10.1038/s41421-021-00321-x.

19. Qian Y, Yu W, Grzeskowiak C, Li J, Huang H, Guo J, Chen L, Wang F, Zhao F, Boehmer L, Metzner T, Leppert J, Chien Y, Kuo C, Davis MM. Nanoparticle-enabled innate immune stimulation activates endogenous tumor infiltrating T cells with broad antigen specificities. PNAS, 2021, doi.org/10.1073/pnas.2016168118.

20. Zhao X, Luo X, Sun R, Wang F#, and Sun X#. The interaction between microglia and macroglia in glaucoma, Frontiers in Neuroscience, 2021, doi: 10.3389/fnins.2021.610788.

21. Wang Y, Zhao X, Gao M, Wan X, Guo Y, Qu Y, Chen Y, Li T, Liu H, Jiang M, Wang F#, and Sun X#. Myosin 1f-mediated Activation of Microglia Contributes to the Photoreceptor Degeneration in a Mouse Model of Retinal Detachment. Cell Death & Disease, 2021, DOI:10.21203/rs.3.rs-80015/v1.

22. Zhao X, Gao M, Liang J, Chen Y, Wang Y, Wang Y, Xiao Y, Zhao Z, Wan X, Jiang M, Luo X, Wang F#, and Sun X#. SLC7A11 Reduces Laser-Induced Choroidal Neovascularization by Inhibiting RPE Ferroptosis and VEGF Production. Frontiers in Cell and Developmental Biology, 2021, Doi: 10.3389/fcell.2021.639851.

23. Ren X, Wen W, Fan X, Hou W, Su B, Cai P, Li J, Liu Y, Tang F, Zhang F, Yang Y, He J, Ma W, He J, Wang P, Cao Q, Chen F, Chen Y, Cheng X, Deng G, Deng X, Ding W, Feng Y, Gan R, Guo C, Guo W, He S, Chen J, Liang J, Li Y, Lin J, Ling Y, Liu H, Liu J, Liu N, Liu S, Luo M, Ma Q, Song Q, Sun W, Wang G, Wang F, Wang Y, Wen X, Wu Q, Xu G, Xie X, Xiong X, Xing X, Xu H, Yin C, Yu D, Yu K, Yuan J, Zhang B, Zhang P, Zhang T, Zhao J, Zhao P, Zhou J, Zhou W, Zhong S, Zhong X, Zhang S, Zhu L, Zhu P, Zou B, Zou J, Zou Z, Bai F, Huang X, Zhou P#, Jiang Q#, Huang Z#, Bei J#, Wei L#, Bian X#, Liu X#, Cheng T#, Li X#, Zhao P#, Wang F#, Wang H#, Su B#, Zhang Z#, Qu K#, Wang X#, Chen J#, Jin R#, Zhang Z#. COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas. Cell, 2021, DOI: 10.1016/j.cell.2021.01.053.

24. Sun S, Luo L, Liang W, Yin Q, Guo J, Rush MA, Lv Z, Liang Q, Fischbach AM, Sonnenburg LJ, Dodd D, Davis MM#, Wang F#. Bifidobacterium alters the gut microbiota and modulates the functional metabolism of Treg cells in the context of CTLA-4 blockade. PNAS, 2020, DOI:https://doi.org/10.1073/pnas.1921223117.

25. Li Y, Wang Y, Yao Y, Griffiths BB, Feng L, Tao T, Wang F, Xu B, Stary CM, Zhao H. Systematic Study of the Immune Components after Ischemic Stroke Using CyTOF Techniques, Journal of Immunology Research, 2020, DOI:https://doi.org/10.1155/2020/9132410.

26. Zeng J, Dong S, Luo Z, Xie X, Fu B, Li P, Liu C, Yang X, Chen Y, Wang X, Liu Z, Wu J, Yan Y, Wang F, Chen J, Zhang J, Long G, Goldman SA, Li S, Zhao Z, Liang Q. The Zika Virus Capsid Disrupts Corticogenesis by Suppressing Dicer Activity and miRNA Biogenesis. Cell Stem Cell, 2020, DOI:https://doi.org/10.1016/j.stem.2020.07.012.

27. Zhang S, Liang W, Luo L, Sun S, Wang F#. The role of T cell trafficking in CTLA-4-blockade induced gut immunopathology. BMC Biology, 2020, 18:29. doi.org/10.1186/s12915-020-00765-9.

28. Leng Q#, Tarbe M, Long Q, Wang F#. Preexisting heterologous T cell immunity and neoantigen immunogenicity. Clinical & Translational Immunology, 2020, 9:3. doi: 10.1002/cti2.1111.

29. Hu Z, Qu G, Yu X, Jiang H, Teng XL, Ding L, Hu Q, Guo X, Zhou Y, Wang F, Li HB, Chen L, Jiang J, Su B#, Liu J#, Zou Q#. Acylglycerol Kinase Maintains Metabolic State and Immune Responses of CD8+ T Cells. Cell Metabolism, 2019, 30(2):290-302.

30. Wang Y, Jin H, Wang W, Wang F#, Zhao H#. Myosin1f-mediated neutrophil migration contributes to acute neuroinflammation and brain injury after stroke in mice. Journal of Neuroinflammation, 2019, 16(1):77. doi: 10.1186/s12974-019-1465-9.

31. Wang F#, Yin Q, Chen L, and Davis MM#. Bifidobacterium can mitigate intestinal immunopathology in the context of CTLA-4 blockade. PNAS, 2018, 115(1): 157-161.

32. Wang F, Beck-García K, Zorzin C, Schamel WW, and Davis MM. Inhibition of T cell receptor signaling by cholesterol sulfate, a naturally occurring derivative of membrane cholesterol. Nature Immunology, 2016, 17(7): 844-850.

33. Zhu P, Wang Y, Oin N, Wang F, Wang J, Deng XW, Zhu D. An Arabidopsis small nucleolar RNA monitors the efficient pre-rRNA processing during ribosome biogenesis. PNAS, 2016, 113(42): 11967-11972.

34. Roh KH, Lillemeier BF, Wang F, and Davis MM. The coreceptor CD4 is expressed in distinct nanoclusters and does not colocalize with T-cell receptor and active protein tyrosine kinase p56lck. PNAS, 2015, 112(13): 1604-1613.

35. Wang F, Deng XW. Plant ubiquitin-proteasome pathway and its role in gibberellin signaling. Cell Research, 2011, 21(9): 1286-1294.

36. Wang F, Zhu D, Huang X, Li S, Gong Y, Yao Q, Fu X, Fan LM, and Deng XW. Biochemical insights on degradation of Arabidopsis DELLA proteins gained from a cell-free assay system. Plant Cell, 2009, 21(8): 2378-2390.

37. Liu Y, Wang F, Zhang H, He H, Ma L, and Deng XW. Functional characterization of the Arabidopsis ubiquitin-specific protease gene family reveals specific role and redundancy of individual members in development. Plant Journal, 2008, 55(5): 844-856.

38. Feng S, Martinez C, Gusmaroli G, Wang Y, Zhou J, Wang F, Chen L, Yu L, Iglesias-Pedraz JM, Kircher S, Schafer E, Fu X, Fan LM, and Deng XW. Coordinated regulation of Arabidopsis thaliana development by light and gibberellins. Nature, 2008, 451(7177): 475-479.