本课题组主要使用双光子显微镜活体成像技术，结合小鼠遗传学，传统免疫学和分子生物学研究方法，探索天然免疫细胞，特别是中性粒细胞在炎症过程中的动态及功能。主要研究方向包括：（1）中性粒细胞在慢性炎症反应中的动态及功能。（2）中性粒细胞和巨噬细胞在炎症组织中的分布和亚型的鉴定。（3）以中性粒细胞为靶向的抗炎症药物研究。

1.  Matthias Bartneck1* and Jing Wang*.Therapeutic Targeting of Neutrophil Granulocytes in Inflammatory Liver Disease<br /> .frontier in Immunology,2019,10.  [Link]

2.  Wang J.Neutrophils in tissue injury and repair.Cell Tissue Res, 2018,371(3):531-539.  [Link]

3.  Wang J, Hossain M, Thanabalasuriar A, Gunzer M, Meininger C, Kubes P.Visualizing the Function and Fate of Neutrophils in Sterile Injury and Repair.Science,2017,358(6359): 111-116.  [Link]

4.  Thanabalasuriar A, Neupane AS, Wang J, Krummel MF, Kubes P.iNKT cell emigration out of the lung vasculature requires neutrophils and monocyte-derived dendritic cells in inflammation.Cell Reports ,2016,16(12): 3260-72.  [Link]

5.  Wang J, Kubes P.A Reservoir of Mature Cavity Macrophages that Can Rapidly Invade Visceral Organs to Affect Tissue Repair.Cell,2016,165(3): 668-78.  [Link]

6.  Slaba I, Wang J, Kolaczkowska E, McDonald B, Lee WY, Kubes P.Imaging the Dynamic Platelet-Neutrophil Response in Sterile Liver Injury and Repair in Mice.Hepatology,2015,62(5): 1590-605.  [Link]

7.  Watson RL, Buck J, Levin LR, Winger RC, Wang J, Arase H, Muller WA.Endothelial CD99 signals through soluble adenylyl cyclase and PKA to regulate leukocyte transendothelial migration.The Journal of Experimental Medicine,2015,212(4): 447-56.  [Link]

8.  Dal-Secco D, Wang J, Zeng Z, Kolaczkowska E, Wong C, Petri B, Ransohoff R, Charo I, Jenne C, Kubes P.A dynamic spectrum of monocytes arising from the in situ reprogramming of CCR2+ monocytes at a site of sterile injury.The Journal of Experimental Medicine,2015 ,212(4): 447-56.  [Link]

9.  Kishida K, Kohyama M, Kurashima Y, Wang J, Hirayasu K, Suenaga T, Kiyono H, Kunisawa J, Arase H.Negative regulation of DSS-induced experimental colitis by PILRa.International Immunology,2015,27(6): 307-14.  [Link]

10.  Kuroki K, Wang J, Ose T, Yamaguchi M, Tabata S, Maita N, Nakamura S, Kajikawa M, Kogure A, Satoh T, Arase H, Maenaka K..Structural basis for simultaneous recognition of an O-glycan and its attached peptide of mucin family by immune receptor PILRa.Proceedings of the National Academy of Sciences,2014,111(24): 8877-82.  [Link]

11.  Wang J, Arase H.Regulation of immune response by neutrophils.Annals of the New York Academy of Sciences ,2014,1319: 66-81.  [Link]

12.  Wang J, Shiratorri I, Uehori J, Ikawa M, Arase H.Neutrophil infiltration during inflammation is regulated by PILRa via modulation of integrin activation.Nature Immunology,2013,14: 34-40.  [Link]

13.  Kogure A, Shiratori I, Wang J, Lanier LL, Arase H.PANP is a novel O-glycosylated PILRa ligand expressed in neural tissues.Biochemical and Biophysical Research Communications,2011,405: 428-33.  [Link]

14.  Arii J, Wang J, Morimoto T, Suenaga T, Akashi H, Arase H, Kawaguchi Y.A single-amino-acid substitution in herpes simplex virus 1 envelope glycoprotein B at a site required for binding to the paired immunoglobulin-like type 2 receptor (PILRa) abrogates PILRa-dependent viral entry and reduces pathogenesis.Journal of Virology,2010,84: 10773-10783.  [Link]

15.  Wang J, Fan Q, Satoh T, Arii J, Lanier LL, Spear PG, Kawaguchi Y, Arase H.Binding of herpes simplex virus glycoprotein B (gB) to paired immunoglobulin-like type 2 receptor  depends on specific sialylated O-linked glycans on gB.Journal of Virology,2009,83: 13042-13045.  [Link]

16.  Satoh T, Arii J, Suenaga T, Wang J, Kogure A, Uehori J, Arase N, Shiratori I, Tanaka S, Kawaguchi Y, Spear PG, Lanier LL, Arase H.PILRa is a herpes simplex virus-1 entry coreceptor that associates with glycoprotein B.Cell ,2008,132: 935-944.  [Link]

17.  Tabata S, Kuroki K, Wang J, Kajikawa M, Shiratori I, Kohda D, Arase H, Maenaka K.Biophysical characterization of O-glycosylated CD99 recognition by paired Ig-like type 2 receptors.Journal of Biological Chemistry,2008,283: 8893-8901.  [Link]

18.  Wang J, Shiratori I, Satoh T, Lanier LL, Arase H.An essential role of sialylated O-linked sugar chains in the recognition of mouse CD99 by paired Ig-like type 2 receptor (PILR).Journal of Immunology,2008,180: 1686-1693.  [Link]

19.  Tabata S, Kuroki K, Maita N, Wang J, Shiratori I, Arase H, Kohda D, Maenaka K.Expression, crystallization and preliminary X-ray diffraction analysis of human paired Ig-like type 2 receptor alpha (PILRa).ActaCrystallographica Section F: Structural Biology and Crystallization Communications,2008,64: 44-46.  [Link]

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实验室电话： 021-54653526-776773

邮          箱： jingwang@shsmu.edu.cn