肿瘤免疫治疗已经被临床应用治疗恶性肿瘤，在一些患者中具有显著疗效，但是依然存在临床响应率低的难题。免疫细胞活性受到细胞代谢调控，研究肿瘤免疫的代谢调控机制将为进一步提高肿瘤免疫治疗疗效提供新的思路和策略。课题组主要围绕肿瘤免疫应答与耐受的代谢调控机制，采用分子、细胞、生化、动物模型、临床样本等，研究参与调控肿瘤免疫代谢的关键因子及其作用机制，探索干预肿瘤免疫代谢提高肿瘤免疫应答的免疫治疗策略。

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