肿瘤免疫治疗已经被临床应用治疗恶性肿瘤，在一些患者中具有显著疗效，但是依然存在临床响应率低的难题。免疫细胞活性受到细胞代谢调控，研究肿瘤免疫的代谢调控机制将为进一步提高肿瘤免疫治疗疗效提供新的思路和策略。课题组主要围绕肿瘤免疫应答与耐受的代谢调控机制，采用分子、细胞、生化、动物模型、临床样本等，研究参与调控肿瘤免疫代谢的关键因子及其作用机制，探索干预肿瘤免疫代谢提高肿瘤免疫应答的免疫治疗策略。

1. 1)Ding R^#, Yu X ^#, Hu Z ^#, Dong Y, Huang H, Zhang Y, Han Q, Ni ZY*, Zhao R*, Ye Y* and Zou Q*. Lactate modulates RNA splicing to promote CTLA-4 expression in tumor-infiltrating regulatory T cells. Immunity, 2024, 57(3), 528–540. (IF: 32.4)

2. 2) Zhang Y^#, Yu X^#, Bao R^#, Huang H, Gu C, Lv Q, Han Q, Du X, Zhao XY, Ye Y*, Zhao R*, Sun J*, Zou Q*. Dietary fructose-mediated adipocyte metabolism drives antitumor CD8⁺ T cell responses. Cell Metabolism, 2023,35(12):2107-2118. (IF: 29.0)

3. 3) Wang A^#, Huang H^#, Shi JH, Yu X, Ding R, Zhang Y, Han Q, Ni ZY*, Li X*, Zhao R*, Zou Q*. USP47 inhibits m6A-dependent c-Myc translation to maintain regulatory T cell metabolic and functional homeostasis. Journal of Clinical Investigation, 2023 Dec 1;133(23):e169365. (IF: 15.9)

4. 4) Hu Z*, Yu X, Ding R, Liu B, Gu C, Pan X, Han Q, Zhang Y, Wan J, Cui X*, Sun J*, Zou Q*. Glycolysis drives STING signaling to facilitate dendritic cell antitumor function. Journal of Clinical Investigation, 2023 Apr 3;133(7):e166031. (IF: 15.9)

5. 5) Wu Z, Huang H, Han Q, Hu Z, Teng XL, Ding R, Ye Y, Yu X*, Zhao R*, Wang Z*, Zou Q*. SENP7 senses oxidative stress to sustain metabolic fitness and antitumor functions of CD8⁺ T cells. Journal of Clinical Investigation, 2022 Apr 1;132(7):e155224. (IF: 19.456)

6. 6) Wang F, Zhang Y, Yu X, Teng XL, Ding R, Hu Z, Wang A, Wang Z*, Ye Y*, Zou Q*. ZFP91 disturbs metabolic fitness and antitumor activity of tumor-infiltrating T cells. Journal of Clinical Investigation. 2021 Oct 1;131(19):e144318. (IF: 14.808)

7. 7) Hu Z^#, Teng XL^#, Zhang T, Yu X, Ding R, Yi J, Deng L*, Wang Z*, Zou Q*. SENP3 senses oxidative stress to facilitate STING-dependent dendritic cell antitumor function. Molecular Cell, 2021, Mar 4;81(5):940-952.e5. (IF: 17.970)

8. 8) Wang A^#, Ding L^#, Wu Z, Ding R, Teng XL, Wang F, Hu Z, Chen L*, Yu X*, Zou Q*. ZFP91 is required for the maintenance of regulatory T cell homeostasis and function. The Journal of Experimental Medicine, 2021 Feb 1;218(2):e20201217. (IF: 14.307)

9. 9) Hu Z^#, Qu G^#, Yu X^#, Jiang H, Teng X-L, Ding L, Hu Q, Guo X, Zhou Y, Wang F, Li H-B, Chen L, Jiang J, Su B*, Liu J*, Zou Q*. Acylglycerol Kinase Maintains Metabolic State and Immune Responses of CD8⁺ T Cells. Cell Metabolism, 2019, 30(2):290-302. (IF: 27.287)

10. 10) Yu X^#, Teng X-L^#, Wang F^#, Zheng Y^#, Qu G, Zhou Y, Hu Z, Wu Z, Chang Y, Chen L, Li H-B, Su B, Lu L*, Liu Z*, Sun S-C*, Zou Q*. Metabolic control of regulatory T cell stability and function by TRAF3IP3 at the lysosome. The Journal of Experimental Medicine, 2018, 215(9):2463-2476. (IF: 14.307)

11. 11) Yu X^#, Lao Y^#, Teng X-L^#, Li S, Zhou Y, Wang F, Guo X, Deng S, Chang Y, Wu X, Liu Z, Chen L, Lu L, Cheng J, Li B, Su B, Jiang J, Li H-B*, Huang C*, Yi J*, Zou Q*. SENP3 maintains the stability and function of regulatory T cells via BACH2 deSUMOylation. Nature Communications, 2018, 9:3157. (IF: 14.919)

12. 12) Xiao Y^#, Zou Q^#, Xie X^#, Liu T, Li H, Jie Z, Jin J, Hu H, Manyam G, Zhang L, Cheng X, Wang H, Marie I, Levy D, Watowich S, and Sun S-C*. The kinase TBK1 functions in dendritic cells to regulate T cell homeostasis, autoimmunity, and antitumor immunity. The Journal of Experimental Medicine, 2017, 214(5):1493-1507.