免疫调控和信号转导研究、肠道免疫和肠炎肠癌等相关疾病研究、血管生成机制及血管相关疾病研究。

本实验室以mTOR信号通路和MAPK级联途径为研究对象，尤其是对丝裂原活化蛋白激酶（MAPK）级联途径和哺乳动物雷帕霉素靶蛋白（mTOR）介导的信号转导通路在免疫反应和血管功能/发育中的生物学功能和意义开展了一系列研究工作。目前研究主要聚焦于MAPK和mTOR信号通路在肠道间质细胞、巨噬细胞、T细胞和固有样淋巴细胞等细胞的调控机制及其在肠道炎症、肿瘤、纤维化等疾病中的作用。

1. Liu H, Li L, Hao Y, Li J, Liu Z, Qi J, Zhang J, Wu N, Wu D, Gao C, Chen L, Shen L, Cheng J, Su B.(通讯作者). Identification of two migratory colon ILC2 populations differentially expressing IL-17A and IL-5/IL-13. Sci China Life Sci. 2023 Jan;66(1):67-80.[Link]

2. Han Y, Ouyang X, Chen Y, Lai S, Sun H, Wu N, Ruan C, Lu L, Su B.(通讯作者). scRNA-seq profiling of neonatal and adult thymus-derived CD4+ T cells by a T cell origin-time tracing model. J Mol Cell Biol. 2022 Dec 20:mjac072. [Link]

3. Sun H, Tan J, Chen H, Wu N, Su B.(通讯作者). Immune niches orchestrated by intestinal mesenchymal stromal cells lining the crypt-villus. Front Immunol. 2022 Nov 3;13:1057932. doi: 10.3389/fimmu.2022.1057932.[Link]

4. Qi J, Sun H, Zhang Y, Wang Z, Xun Z, Li Z, Ding X, Bao R, Hong L, Jia W, Fang F, Liu H, Chen L, Zhong J, Zou D, Liu L, Han L, Ginhoux F, Liu Y, Ye Y, Su B.(通讯作者). Single-cell and spatial analysis reveal interaction of FAP+ fibroblasts and SPP1+ macrophages in colorectal cancer. Nat Commun. 2022 Apr 1;13(1):1742. [Link]

5. Wu N, Sun H, Zhao X, Zhang Y, Tan J, Qi Y, Wang Q, Ng M, Liu Z, He L, Niu X, Chen L, Liu Z, Li HB, Zeng YA, Roulis M, Liu D, Cheng J, Zhou B, Ng LG, Zou D, Ye Y, Flavell RA, Ginhoux F, Su B.(通讯作者).MAP3K2-regulated intestinal stromal cells define a distinct stem cell niche.Nature, 2021 Apr;592(7855):606-610.  [Link]
   

6. Qi, J, A Crinier, B Escaliere, Y Ye, Z Wang, T Zhang, L Batista, H Liu, L Hong, N Wu, M Zhang, L Chen, Y Liu, L Shen, E Narni-Mancinelli, E Vivier and B Su.(通讯作者). Single-cell transcriptomic landscape reveals tumor specific innate lymphoid cells associated with colorectal cancer progression.Cell Rep Med，2021 2(8): 100353.  [Link]
   

7. Ren X, Wen W, Fan X, Hou W, Su B, Cai P, Li J, Liu Y, Tang F, Zhang F, Yang Y, He J, Ma W, He J, Wang P, Cao Q, Chen F, Chen Y, Cheng X, Deng G, Deng X, Ding W, Feng Y, Gan R, Guo C, Guo W, He S, Jiang C, Liang J, Li YM, Lin J, Ling Y, Liu H, Liu J, Liu N, Liu SQ, Luo M, Ma Q, Song Q, Sun W, Wang G, Wang F, Wang Y, Wen X, Wu Q, Xu G, Xie X, Xiong X, Xing X, Xu H, Yin C, Yu D, Yu K, Yuan J, Zhang B, Zhang P, Zhang T, Zhao J, Zhao P, Zhou J, Zhou W, Zhong S, Zhong X, Zhang S, Zhu L, Zhu P, Zou B, Zou J, Zuo Z, Bai F, Huang X, Zhou P, Jiang Q, Huang Z, Bei JX, Wei L, Bian XW, Liu X, Cheng T, Li X, Zhao P, Wang FS, Wang H, Su B (通讯作者), Zhang Z, Qu K, Wang X, Chen J, Jin R, Zhang Z.COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas.Cell, 2021 Apr 1;184(7):1895-1913.e19.  [Link]

8. Yang XD, Li W, Zhang S, Wu D, Jiang X, Tan R, Niu X, Wang Q, Wu X, Liu Z, Chen LF, Qin J, Su B（通讯作者）. PLK4 deubiquitination by Spata2-CYLD suppresses NEK7-mediated NLRP3 inflammasome activation at the centrosome. EMBO J， 2020 Jan 15;39(2):e102201.  [Link]

9. Liu Z, Gu Y, Chakarov S, Bleriot C, Kwok I, Chen X, Shin A, Huang W, Dress RJ, Dutertre CA, Schlitzer A, Chen J, Ng LG, Wang H, Liu Z, Su B(通讯作者), Ginhoux F. Fate mapping via Ms4a3 expression history traces monocyte-derived cells. Cell， 2019 Sep 5;178(6):1509-1525.  [Link]

10. Hu Z, Qu G, Yu X, Jiang H, Teng XL, Ding L, Hu Q, Guo X, Zhou Y, Wang F, Li HB, Chen L, Jiang J, Su B(通讯作者), Liu J, Zou Q. Acylglycerol Kinase Maintains Metabolic State and Immune Responses of CD8+T Cells. Cell Metabolism， 2019 Aug 6;30(2):290-302.  [Link]

11. Ruan C, Ouyang X, Liu H, Li S, Jin J, Tang W, Xia Y, and Su B（通讯作者） . Sin1-mediated mTOR Signaling in Cell Growth, Metabolism and Immune Response. National Science Review， 2019, Nov. 19; 6:1149-116.  [Link]

12. M Li, AS Lazorchak, X Ouyang, H Zhang, H Liu, O.A Arojo, G Qu, X Xu, X Liu, W Zhang, Q Wang, D Liu, F Li,B Su.（通讯作者）.Sin1/mTORC2 regulates B cell growth and metabolism via mTORC1 and Myc activation.Cell Mol Immunol,2019,doi: 10.1038/s41423-018-0185-x..  [Link]

13. OA. Arojo, X Ouyang, D Liu, T Meng, SM. Kaech, JP. Pereira and B Su.（通讯作者）.Active mTORC2 Signaling in Naive T Cells Suppresses Bone Marrow Homing by Inhibiting CXCR4 Expression ..J Immunol, 2018,201:908-915.  [Link]

14. Xuemei Fan, Conghui Wang, Panlai Shi, Wen Gao, Jianmin Gu, Yan Geng, Wenlong Yang, Ningbo Wu, Yang Wang, Yanyan Xu, Xue Chen, Lin Zhang, Kemin Wang,Bing Su（通讯作者） and Junling Liu.. Platelet MEKK3 regulates arterial thrombosis and myocardial infarct expansion in mice.Blood Adv,2018,26;2(12):1439-1448.  [Link]

15. Wu ZR, Yan LC, Liu YT, Cao L, Guo YH, Zhang Y, Yao H, Cai L, Shang HB, Rui WW, Yang G, Zhang XB, Tang H, Wang Y, Huang JY, Wei YX, Zhao WG, Su B（通讯作者） and Wu ZB.Selective mTORC1 inhibition by lncRNA H19 via disruption of the 4E-BP1 and Raptor interaction in pituitary tumors .Nature Communications,2018, 9:4624.  [Link]

16. Xu YY, Ouyang XX, Yan LC, Zhang ML, Hu ZL, Gu JM, Fan XM, Zhang L, Zhang JF, Xue S, Chen GQ, Su B（通讯作者）, and Liu JL.Sin1 regulates ischaemia-induced microthrombosis through integrin αIIbβ3-mediated outside-in signaling and hypoxia responses in platelets. . Arteriosclerosis, Thrombosis, and Vascular Biology.,2018,32.(in press).  [Link]

17. X Ouyang, Y Han, G Qu, M Li, O Arojo, H Sun, X Liu, D Liu, LChen, Q Zou, Bing Su.（通讯作者）.Metabolic regulation of T cell development by Sin1-mTORC2 is mediated by pyruvate kinase M2. . J Mol Cell Biol,2018,11(2):93-106.  [Link]

18. Zepp JA, Zhao J, Liu C, Bulek K, Wu L, Chen X, Hao Y, Wang Z, Wang X, Ouyang W, Kalady MF, Carman J, Yang WP, Zhu J, Blackburn C Huang YH, Hamilton TA1,2, Su B （通讯作者）and  LiX..IL-17A-Induced PLET1 Expression Contributes to Tissue Repair and Colon Tumorigenesis.. J Immunol,2017,199(11):3849-3857.  [Link]

19. Tan R, Nakajima S, Wang Q, Sun H,Xue J, Wu J, Hellwig S, Zeng X, Yates NA7, Smithgall TE, Lei M, Jiang Y, Levine AS, Su B（通讯作者）, Lan L.Nek7 Protects Telomeres from Oxidative DNA Damage by Phosphorylation and Stabilization of TRF1.Mol Cell,2017 ,65(5):818-831.  [Link]

20. Wang Q, Tan R, Zhu X, Zhang Y, Tan Z, Su B（通讯作者）, Li Y .Oncogenic K-ras confers SAHA resistance by up-regulating HDAC6 and c-myc expression.Oncotarget,2016,7(9):10064-72..  [Link]

21. Pengda Liu, Wenjian Gan, Y. Rebecca Chin, Kohei Ogura, Jianping Guo, Jinfang Zhang, Bin Wang, Blenis J, Cantley LC, Toker A, Su B（通讯作者）, Wei W.PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex.Cancer Discov,2015,5(11):1194-209.  [Link]

22. Fisher OS, Deng H, Liu D, Zhang Y, Wei R, Deng Y, Zhang F, Louvi A, Turk BE, Boggon TJ, Su B. （通讯作者）.Structure and vascular function of MEKK3-cerebral cavernous malformations 2 complex. Nat Commun,2015,6:7937.  [Link]

23. Xing Chang, Fang Liu, Xiaofang Wang, and Su B. （通讯作者）.MEKK2 and MEKK3 regulate TGF-b-mediated helper T cell differentiation. Immunity,2011,34: 201-212,.  [Link]

24. Valeria Facchinetti, Weiming Ouyang, Hua Wei, Nelyn Soto, Adam Lazorchak, Christine Gould, Carolyn Lowry, Alexandra C. Newton, Yuxin Mao, Robert Q. Miao, William C. Sessa, Jun Qin, Pumin Zhang, Su B（通讯作者）, and Estela Jacinto..The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C. EMBO J,2008,44.27(14):1932-43, .  [Link]

25. Jacinto E, Facchinetti V, Liu D, Soto N, Wei S, Jung SY, Huang Q, Qin J, Su B.（通讯作者）.SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell,2006,127(1):125-37. .  [Link]

26. Qiaojia Hunag, Jianhua Yang, Jinke Cheng, CM Walker, Z.G. Liu, and Su B.（通讯作者）.Differential regulation of interleukin-1 receptor and toll like receptor (TLR) signaling by MEKK3.Nature Immunology,2004,5:95-103.  [Link]

27. Yang J, Boerm M, McCarty M, Bucana C, Fidler J, Zhuang Y, and Su B.（通讯作者）.Essential role of MEKK3 in TNF-induced NF-kB activation.Nature Immunology,2001,2：624.  [Link]

28. Su B.（第一作者）, Jacinto, E., Hibi, M., Kallunki, T., Karin, M., and Ben-Neriah, Y. .JNK mediates signal integration during costimulation of T lymphocytes..Cell  ,1994,77:727-736,.  [Link]