起源NOD-SCID小鼠是由非肥胖性糖尿病小鼠（NOD/Lt）和SCID小鼠杂交建立的一种重度免疫缺陷小鼠。相对于SCID小鼠，NOD-SCID小鼠T、B淋巴细胞缺陷，各种肿瘤细胞可以植入，且较少发生排斥反应及移植物抗宿主病（graft-versus-host, GVHD）。
NOD-SCID的小鼠还具有NK细胞活性低、无循环补体、巨噬细胞和抗原呈递细胞（antigen-presenting cell, APC）功能受损的特点。这种重度免疫缺陷小鼠的缺点是仍有残留的NK细胞活性，生存时间比SCID更短，限制了长期研究。NOD-SCID小鼠因易产生胸腺淋巴瘤，也是导致其寿命较短的因素之一。
特征与用途
◇病理：非肥胖糖尿病重症联合免疫缺陷。
◇用途：常用于肿瘤、免疫学、胚胎干细胞、艾滋病及肝炎研究，为T' B' NK细胞缺陷的严重联合免疫缺陷动物模型。人造血干细胞领域、肿瘤细胞等移植方面的研究。通过对NOD SCID进行细胞移植来研究糖尿病发病原理。
目前国际公认的免疫缺陷程度最高、最适合人源细胞移植的工具小鼠，由于不同开发公司命名不同，NOG和NSG、NPG、NDG的缺陷基因是一致的，均为NOD- Prkdcscid -IL2rgtm1突变纯合子小鼠。
来源于Charles River的小鼠生长曲线和生理指标：
来源于Taconic小鼠的生长曲线和生理指标：
2020 Diabetes Incidence in NOD Production Colony (VRG34)
NOD Physiological Data Summary (July 2004; N=10/group):
ParameterUnitsNOD MalesNOD Females
|
|
|
|
Serum Chemistry |
Avg ± S.D. |
|
|
Calcium |
mg/dL |
10.6 ± 0.6 |
11.1 ± 0.3 |
Phosphorous |
mg/dL |
11.8 ± 2.0 |
10.2 ± 3.6 |
Glucose |
mg/dL |
116 ± 18 |
88 ± 17 |
Creatinine |
mg/dL |
0.1 ± 0.0 |
0.1 ± 0.1 |
BUN |
mg/dL |
22 ± 2 |
17 ± 6 |
Total Bilirubin |
mg/dL |
0.2 ± 0.1 |
0.1 ± 0.0 |
ALK |
U/L |
180 ± 11 |
184 ± 21 |
ALT U/L |
U/L |
67 ± 63 |
44 ± 11 |
Total Protein |
g/dL |
6.1 ± 0.6 |
6.2 ± 0.1 |
Blood Counts |
Erythron |
|
|
|
Red Blood Cells |
X10^6/uL |
8.54 ± 0.575 |
8.955 ± 0.476 |
Nucleated RBC |
X10^6/uL |
0 ± 0 |
0 ± 0 |
Hemoglobin |
g/dL |
15.2 ± 0.5 |
15.1 ± 0.7 |
Hematocrit |
% |
46.7 ± 3.5 |
46.2 ± 2.5 |
MCV |
fL |
55 ± 1 |
52 ± 0 |
MCH |
pG |
17.8 ± 1.0 |
16.9 ± 0.2 |
MCHC |
% |
32.7 ± 2.1 |
32.7 ± 0.4 |
Platelets |
|
|
|
Platelets |
X10^3/uL |
1165 ± 334 |
1127 ± 291 |
Leukogram |
|
|
|
White Blood Cells |
x10^3/uL |
3.654 ± 0.875 |
5.438 ± 1.234 |
Neutrophil |
x10^3/uL |
1.211 ± 0.326 |
2.011 ± 0.872 |
Bands |
x10^3/uL |
0 ± 0 |
0 ± 0 |
Lymphocyte |
x10^3/uL |
2.400 ± 0.999 |
3.380 ± 1.139 |
Monocytes |
x10^3/uL |
0.039 ± 0.068 |
0.016 ± 0.030 |
Eosinophil |
x10^3/uL |
0.003 ± 0.010 |
0.031 ± 0.063 |
Basophils |
x10^3/uL |
0 ± 0 |
0 ± 0 |
Others |
x10^3/uL |
0 ± 0 |
0 ± 0 |
Organ Weights |
|
|
|
Stomach |
g |
0.275 ± 0.016 |
0.257 ± 0.025 |
Ileum |
g |
0.791 ± 0.062 |
0.799 ± 0.098 |
Colon |
g |
0.206 ± 0.042 |
0.192 ± 0.050 |
Lungs |
g |
0.228 ± 0.024 |
0.226 ± 0.025 |
Heart |
g |
0.174 ± 0.032 |
0.136 ± 0.017 |
Liver |
g |
1.139 ± 0.072 |
0.955 ± 0.076 |
Spleen/Pancreas |
g |
0.228 ± 0.032 |
0.193 ± 0.027 |
Kidney (L) |
g |
0.204 ± 0.017 |
0.137 ± 0.011 |
Kidney (R) |
g |
0.204 ± 0.017 |
0.138 ± 0.013 |
Testes (L) |
g |
0.103 ± 0.008 |
- |
Testes (R) |
g |
0.189 ± 0.268 |
- |
Ovary (L) |
g |
- |
0.020 ± 0.008 |
Ovary (R) |
g |
- |
0.021 ± 0.012 |
Urinalysis |
|
|
|
Glucose |
mg/dL |
Negative |
Negative |
Blood |
- |
Negative |
Negative |
PH |
- |
6.85 ± 0.41 |
6.45 ± 0.16 |
Protein |
mg/dL |
Negative |
Negative |
Specific Gravity |
- |
1.01 ± 0.01 |
1.02 ± 0.00 |
来源于Jackson Lab的小鼠生长曲线和生理指标：
