梁伟 博士后

邮箱：liangwei768541@icloud.com

研究方向：细胞死亡和炎症在人类疾病中的作用

教育经历：

2009年9月---2013年6月? 沈阳药科大学 本科

2013年6月---2019年12月 中国科学院上海有机化学研究所 博士

工作经历

2020年1月---2021年10月? 中国科学院上海有机化学研究所 科研助理

2021年11月---2024年11月 上海奕拓医药科技有限公司 研发副主任I

发表文章

1: Liang W, Qi W, Geng Y, Wang L, Zhao J, Zhu K, Wu G, Zhang Z, Pan H, Qian L,Yuan J. Necroptosis activates UPR sensors without disrupting their binding with GRP78. Proc Natl Acad Sci U S A. 2021 Sep 28;118(39): e2110476118. doi:10.1073/pnas.2110476118. PMID: 34544877; PMCID: PMC8488584.

2: Liang W, Yuan J. Visualizing Endogenous Necrosomes in Necrosomes by In Situ Proximity Ligation Assay. Curr Protoc. 2022 Feb;2(2): e388. doi:10.1002/cpz1.388. PMID: 35195947.

3: Wu G, Li D, Liang W, Sun W, Xie X, Tong Y, Shan B, Zhang M, Lu X, Yuan J, LiY. PP6 negatively modulates LUBAC-mediated M1-ubiquitination of RIPK1 and c-FLIP to promote TNFα-mediated cell death. Cell Death Dis. 2022 Sep7;13(9):773. doi: 10.1038/s41419-022-05206-9. PMID: 36071040; PMCID: PMC9452587.

4: Zhu K, Liang W, Ma Z, Xu D, Cao S, Lu X, Liu N, Shan B, Qian L, Yuan J.Necroptosis promotes

cell-autonomous activation of proinflammatory cytokine gene expression. Cell Death Dis.2018 May 1;9(5):500. doi: 10.1038/s41419-018-0524-y. PMID: 29703889; PMCID: PMC5923285.

5: Li X, Zhang M, Huang X, Liang W, Li G, Lu X, Li Y, Pan H, Shi L, Zhu H, Qian L, Shan B, Yuan J. Ubiquitination of RIPK1 regulates its activation mediated by TNFR1 and TLRs signaling in distinct manners. Nat Commun. Dec11;11(1):6364. doi: 10.1038/s41467-020-19935-y. PMID: 33311474; PMCID: PMC7733462.

6: Xu D, Shan B, Sun H, Xiao J, Zhu K, Xie X, Li X, Liang W, Lu X, Qian L, YuanJ. USP14 regulates autophagy by suppressing K63 ubiquitination of Beclin 1. Genes Dev. 2016 Aug 1;30(15):1718-30. doi: 10.1101/gad.285122.116. PMID:27542828; PMCID: PMC5002977.

7: Zu R, Yu Z, Zhao J, Lu X, Liang W, Sun L, Si C, Zhu K, Zhang T, Li G, Zhang M, Zhang Y, Liu N, Yuan J, Shan B. Quantitative analysis of phosphoproteome in necroptosis reveals a role of TRIM28 phosphorylation in promoting necroptosis-induced cytokine production. Cell Death Dis. 2021 Oct 23;12(11):994. doi:10.1038/s41419-021-04290-7. PMID: 34689152; PMCID: PMC8542044.

8: Zhang T, Dong K, Liang W, Xu D, Xia H, Geng J, Najafov A, Liu M, Li Y, Han X, Xiao J, Jin Z, Peng T, Gao Y, Cai Y, Qi C, Zhang Q, Sun A, Lipinski M, Zhu H, Xiong Y, Pandolfi PP, Li H, Yu Q, Yuan J. G-protein-coupled receptors regulate autophagy by ZBTB16-mediated ubiquitination and proteasomal degradation of Atg14L. Elife. 2015 Mar 30;4:e06734. doi: 10.7554/eLife.06734. PMID: 25821988; PMCID: PMC4421748.

9: Xu D, Shan B, Lee BH, Zhu K, Zhang T, Sun H, Liu M, Shi L, Liang W, Qian L,Xiao J, Wang L, Pan L, Finley D, Yuan J. Phosphorylation and activation of ubiquitin-specific protease-14 by Akt regulates the ubiquitin-proteasome system. Elife. 2015 Nov 2;4:e10510. doi: 10.7554/eLife.10510. PMID: 26523394; PMCID: PMC4733041