陈欣 研究员
邮箱: xinchen@shsmu.edu.cn
电话:021-67722498
研究方向: 脑肿瘤的机械特性与机械敏感性离子通道的功能
教育经历
2011-2015 年 中国科学院大学神经生物学,博士
2009-2011 年 中国科学院大学神经生物学,硕士
2005-2009 年 武汉大学生物学,学士
工作经历
2023年-至 今 上海交通大学医学院松江研究院,研究员
2015-2022 年 加拿大多伦多大学病童医院干细胞生物发育及脑肿瘤研究所,博士后
课题组长简介:
陈欣,上海交通大学医学院松江研究院研究员,博士生导师。围绕机械敏感性离子通道调控脑肿瘤力学微环境的功能开展全方位研究。主要研究成果以第一作者/共同通讯作者发表在Neuron 2018(2018-2019 Neuron最佳论文),Neuron 2023(封面论文),J. Neurosci. 2015,J. Transl. Med. 2023 等学术杂志。主持国家自然科学基金面上等项目。课题组长获得了国家级和上海市的科研引才项目资助,可以保证科研课题的顺利运行。现任中国神经科学学会神经肿瘤分会、中国抗癌协会肺癌整合防筛专业委员会、中国微循环学会神经免疫专委会委员,Frontiers in Immunology 客座编辑。担任国际学术期刊Advanced Science、Signal Transduction and Targeted Therapy等杂志审稿人。

课题组关注脑肿瘤及其微环境细胞的机械特性,并探究其中机械信号、电信号和生化信号的相互关联;同时专注于以机械敏感性离子通道为精准诊疗靶点,以期改善脑肿瘤异常的机械特性,达到缓解和治疗病症的目的。主要研究方向为:
1. 解析脑肿瘤干细胞的生物力学特性对其静息态和激活态转换的影响,以及对细胞生化特征的调控,并阐明机械敏感性离子通道在其中的作用。
2. 研究机械敏感性离子通道对脑肿瘤微环境中神经细胞与胶质细胞机械特性的调节以及对其电活动和生化通路的影响,阐明它们在脑肿瘤发生和发展过程中的功能与机制。
3. 探索机械敏感性离子通道对神经免疫系统机械特性的调节,关注相关生物力学过程对神经肿瘤形成和发展的影响和机制。
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张君妍 青年副研究员 邮箱: 研究方向:生物基纳米复合材料、杂化多孔材料、多功能荧光探针、脑肿瘤力学调控
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孔柏达 博士后 邮箱:934184141@qq.com 研究方向:脑肿瘤免疫系统的力学调控
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高超 博士后 邮箱:mangokingg@163.com 研究方向:细胞力学与组织修复,神经退行性疾病的蛋白团聚研究
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陈洋洋 实验室管家 科研助理 邮箱:chenyangyangwf@163.com 研究方向:肿瘤的力学特性与神经调控
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石楠 科研助理 邮箱:shinan188@163.com 研究方向:脑肿瘤的力学微环境调控
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吴君 科研助理 邮箱:wujun224@shsmu.edu.cn 研究方向:肿瘤的力学特性与代谢调控
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李乾泉 博士研究生 邮箱:2696480763@sjtu.edu.cn 研究方向:
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沈怡欢 硕士研究生 邮箱:shenyihuan@sjtu.edu.cn 研究方向:脑肿瘤的力学-神经信号互作
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汪芷伊 硕士研究生 邮箱:wwwzy014@163.com 研究方向:
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张益浩 联合培养博士生 邮箱:710895951@qq.com 研究方向:脑肿瘤的力学信号解码
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盛阮妹 访问学者 邮箱:shengruanmei@126.com 研究方向:脓毒症脑病机制
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Xin Chen#, Ali Momin#, Siyi Wanggou#, Xian Wang, Hyun-Kee Min, Wenkun Dou, Jade Chan, Weifan Dong, Jerry J. Fan, Yi Xiong, Kamilia Talipova, Hongyu Zhao, Yuki X. Chen, Kelly Veerasammy, Adam Fekete, Sachin A. Kumar, Hongwei Liu, Qi Yang,Joe Eun Son, Zhengchao Dou, Malini Hu, Parnian Pardis, Kyle Juraschka, Laura Donovan, Jiao Zhang, Vijay Ramaswamy, Hayden Selvadurai, Peter B. Dirks, Michael D. Taylor, Lu-Yang Wang, Chi-chung Hui, Rinat Abzalimov, Ye He, Yu Sun, Xuejun Li*, and Xi Huang*. Mechanosensitive brain tumor cells construct blood-tumor barrier to mask chemosensitivity. Neuron, 2023, 111: 1-19. (Cover Article)
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Xin Chen, Siyi Wanggou, Ankur Bodalia, Min Zhu, Weifan Dong, Jerry J. Fan, Wen Chi Yin, Hyun-Kee Min, Malini Hu, Diana Draghici, Wenkun Dou, Feng Li, Fiona J. Coutinho, Heather Whetstone, Michelle M. Kushida, Peter B. Dirks, Yuanquan Song, Chi-chung Hui, Yu Sun, Lu-Yang Wang, Xuejun Li, and Xi Huang. A feedforward mechanism mediated by mechanosensitive ion channel PIEZO1 and tissue mechanics promotes glioma aggression. Neuron, 2018, 100(4):799-815 (Best of Neuron 2018 and 2019)
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Xin Chen, Mei-Yu Ruan, and Shi-Qing Cai. KChIP-like Auxiliary Subunits of Kv4 Channels Regulate Excitability of Muscle Cells and Control Male Turning Behavior during Mating in Caenorhabditis elegans. Journal of Neuroscience, 2015, 35:1880 –1891.
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Yi Xiong#, Yihao Zhang#, Na Liu, Yueshuo Li, Hongwei Liu, Qi Yang, Yu Chen, Zhizhi Xia, Xin Chen*, Siyi Wanggou* and Xuejun Li*. Integration of single-cell regulon atlas and multi-omics data for prognostic stratification and personalized treatment prediction in human lung adenocarcinoma. Journal of Translational Medicine, 2023, 25;21(1):499.
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Min Zhu, Bin Gu, Evan C Thomas, Yunyun Huang, Yun-Kyo Kim, Hirotaka Tao, Theodora M Yung, Xin Chen, Kaiwen Zhang, Elizabeth K Woolaver, Mikaela R Nevin, Xi Huang, Rudolph Winklbauer, Janet Rossant, Yu Sun*, Sevan Hopyan*. A fibronectin gradient remodels mixed-phase mesoderm. Science Advances, 2024, 10(29): eadl6366
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Alexander T Bahcheli#, Hyun-Kee Min#, Masroor Bayati, Hongyu Zhao, Alexander Fortuna, Weifan Dong, Irakli Dzneladze, Jade Chan, Xin Chen, Kissy Guevara-Hoyer, Peter B Dirks, Xi Huang*, Jüri Reimand*. Pan-cancer ion transport signature reveals functional regulators of glioblastoma aggression. The EMBO Journal, 2024, 43(2):196-224.
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Meryem B Baghdadi, Ronja M Houtekamer , Louisiane Perrin , Abilasha Rao-Bhatia, Myles Whelen, Linda Decker, Martin Bergert, Carlos Pérez-Gonzàlez, Réda Bouras, Giacomo Gropplero, Adrian K H Loe, Amin Afkhami-Poostchi, Xin Chen, Xi Huang, Stephanie Descroix, Jeffrey L Wrana, Alba Diz-Muñoz, Martijn Gloerich, Arshad Ayyaz, Danijela Matic Vignjevic#, Tae-Hee Kim#. PIEZO-dependent mechanosensing is essential for intestinal stem cell fate decision and maintenance. Science. 2024 Nov 29;386(6725):eadj7615.
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Biren M Dave, Xin Chen, Fraser McCready, Connor S Charton, Rachel M Morley, Jignesh K Tailor, James Ellis, Xi Huang, and Peter B Dirks. Directed differentiation of human hindbrain neuroepithelial stem cells recapitulates cerebellar granule neurogenesis. Development, 2023, 150(13): dev201534.
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Wentian Tang, Xin Chen, Xian Wang, Min Zhu, Guanqiao Shan, Tiancong Wang, Wenkun Dou, Jintian Wang, Juhui Law, Zheyuan Gong, Sevan Hopyan*, Xi Huang*, and Yu Sun*. Indentation Induces Instantaneous Nuclear Stiffening and Unfolding of Nuclear Envelop Wrinkles. Proceedings of the National Academy of Sciences, 2023,120(36):e2307356120.
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Wenkun Dou, Abdelkader Daoud, Xin Chen, Tiancong Wang, Manpreet Malhi, Zheyuan Gong, Fatemeh Mirshafiei, Min Zhu, Guanqiao Shan, Xi Huang, Jason T. Maynes*, and Yu Sun*. Ultrathin and flexible bioelectronic arrays for functional measurement of iPSC-cardiomyocytes under cardiotropic drug administration and controlled microenvironments. Nano Letters, 2023, 23(6): 2321-2331.
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Xian Wang, Zheyuan Gong, Tiancong Wang, Junhui Law, Xin Chen, Siyi Wanggou, Jintian Wang, Binbin Ying, Michelle Francisco, Weifan Dong, Yi Xiong, Jerry J. Fan, Graham MacLeod, Stephane Angers, Xuejun Li, Peter B. Dirks, Xinyu Liu, Xi Huang*, Yu Sun*. Mechanical nanosurgery of chemoresistant glioblastoma using magnetically controlled carbon nanotubes. Science Advances, 2023, 9(13): eade5321
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Weifan Dong, Adam Fekete, Xiaodi Chen, Hongwei Liu, Greg Beilhartz, Xin Chen, ShahrzadBahrampour, Yi Xiong, Qi Yang, Hongyu Zhao, Tian Kong, Malia Morioka, Geena Jung, Ji-EunKim, Daniel Schramek, Peter B. Dirks, Yuanquan Song, Tae-Hee Kim, Ye He, Siyi WanggouXuejun Li, Roman Melnyk, Lu-Yang Wang, Xi Huang. A designer peptide to treat glioblastomaby targeting EAG2-Kvβ2 potassium channel complex-mediated cancer-neuron interaction. Nature Cancer, 2023,4(10):1418-1436.
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Xian Wang#, Tiancong Wang#, Xin Chen, Junhui Law, Guanqiao Shan, Wentian Tang, Zheyuan Gong, Peng Pan, Xinyu Liu, Jiangfan Yu, Changhai Ru*, Xi Huang*, and Yu Sun*. Microrobotic Swarms for Intracellular Measurement with Enhanced Signal-to-Noise Ratio. ACS nano, 2022, 16(7): 10824-10839.
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Ali Momin#*, Shahrzad Bahrampour#, Hyun-Kee Min#, Xin Chen#, Xian Wang, Yu Sun, and Xi Huang*. Channeling force in the brain: mechanosensitive ion channels choreograph mechanics and malignancies. Trends in Pharmacological Sciences, 2021, 42(5):367-384 (Invited Review, Cover Article)
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Michael Pryszlak#, Mallory Wiggans#, Xin Chen, Shyam Patel, Julia Jaramillo, Sarah Burns, Laura Richards, Trevor Pugh, David Kaplan, Xi Huang, Peter Dirks, and Bret J. Pearson. The DEAD-box helicase DDX56 is a conserved stemness regulator in normal and cancer stem cells. Cell Reports, 2021, 34(13):1-16
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Zhuoran Zhang, Changsheng Dai, Guanqiao Shan, Xin Chen, Hang Liu, Khaled Abdalla, Iryna Kuznyetsova, Sergey Moskovstev, Xi Huang, Clifford Librach, Keith Jarvi and Yu Sun. Quantitative selection of single human sperm with high DNA integrity for intracytoplasmic sperm injection.. Fertility and Sterility, 2021, 116(5):1308-1318
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Michelle A. Francisco, Siyi Wanggou, Jerry J. Fan, Weifan Dong, Xin Chen, Ali Momin, Namal Abeysundara, Hyun-Kee Min, Jade Chan, Rochelle McAdam, Marian Sia, Ronwell J. Pusong, Shixuan Liu, Nish Patel, Vijay Ramaswamy, Xiaochong Wu, Noriyuki Kijima, Lu-Yang Wang, Yuanquan Song, Ran Kafri, Michael D. Taylor, Xuejun Li*, and Xi Huang*. Chloride intracellular channel 1 cooperates with potassium channel to promote medulloblastoma growth. Journal of Experimental Medicine, 2020, 217(5):1-19
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Qiang Jiang#, Kai Li#, Wen-Jing Lu, Shuang Li, Xin Chen, Xi-Juan Liu, Jie Yuan, Qiurong Ding, Feng Lan*, and Shi-Qing Cai*. Identification of small-molecule ion channel modulators in C.elegans channelopathy models. Nature Communications, 2018, 9(1):1-12
地址: 上海市松江区中山中路746号18号楼305室
邮编:201699
电话/传真:021-67722498
邮箱:xinchen@shsmu.edu.cn