当前位置：
孙莲慧 青年研究员
邮箱：lhsun2025@shsmu.edu.cn
研究方向：细胞代谢与肿瘤免疫
教育经历
2009-2015年 华东师范大学生命医学研究所，博士
2005-2009年 临沂大学生命与科学学院，学士
工作经历
2025年-至今 上海交通大学医学院松江研究院，青年研究员
2024-2025年 上海交通大学医学院附属第一人民医院，副研究员
2015-2024年 上海交通大学医学院附属第一人民医院，助理研究员
课题组长简介：
孙莲慧，独立PI，青年研究员，硕导。2015年博士毕业于华东师范大学生命医学研究所，同年入职上海交通大学医学院附属第一人民医院临床转化研究院，于2025年03月入职上海交通大学医学院松江研究院/上海交通大学细胞与基因治疗研究院。研究方向聚焦于脑肿瘤或脑转移瘤相关的肿瘤类型，围绕细胞代谢与肿瘤免疫微环境调控分子机制，提出肿瘤治疗新靶点、新策略、新方法。研究成果以第一或通讯（含共同）作者在Nature Communications (4篇)、Current Biology (Nature Review专评文章)、Cell Reports、Advanced Science（封面杂志）等期刊发表多篇研究论文，获得国家发明专利3项。主持国家自然科学基金青年项目、面上项目，入选上海市扬帆计划，山东省泰山学者青年专家项目等。现任北京慢性病防治与健康教育研究会委员、Exploration杂志青年编委。
孙莲慧 青年研究员
实验室聚焦于脑肿瘤或脑转移瘤相关的肿瘤类型，如胶质母细胞瘤、肺癌脑转移瘤、乳腺癌脑转移瘤等，围绕细胞代谢与肿瘤免疫微环境调控分子机制，提出肿瘤治疗新靶点、新策略、新方法，并致力于开发肿瘤早筛技术、肿瘤耐药复发的新分子标志物的转化及应用。
方向一：围绕蛋白质翻译后修饰，研究与细胞代谢异常相关的蛋白质功能及其调控，揭示其生理和病理意义。
方向二：围绕肿瘤细胞与免疫微环境调控的信号分子通路，研究肿瘤免疫微环境重塑的机制。
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1. Xiadi He, Qiwei Wang, Xin Cheng, Weihua Wang, Yutong Li, Yabing Nan, Jiang Wu, Bingqiu Xiu, Tao Jiang, Johann S. Bergholz, Hao Gu, Fuhui Chen, Guangjian Fan, Lianhui Sun, Shaozhen Xie, Junjie Zou, Sheng Lin, Yun Wei, James Lee, John M. Asara, Ke Zhang, Lewis C. Cantley, and Jean J. Zhao. Lysine vitcylation is a vitamin C-derived protein modification that enhances STAT1-mediated immune response. Cell, 2025, 188, 1-20.
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2. Lianhui Sun#, Guangjian Fan#, Zhuqing Zhang#, Dong Chang, Xiaoyu Zhang, Tongqing Zhang, Jichuan Geng, Xiaoxia Zhang, Menghan Lin, Chen Hu, Jiaqi Zhou, Mengxue Wang, Liu Cao, Mary Zhang, Baokun He, Shengping Zhang* and Chuangui Wang*. Phosphorylation of SIRT7 by ATM causes DNA mismatch repair downregulation and adaptive mutability during chemotherapy. Cell Reports, 2025, 44, 115269.
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3. Boyu Yang#, Shiyun Liu#, Tianming Cheng#, Xijian Liu, Jian Song, Xuanhao Li, Fangzhou Zhao, Jingcheng Lv, Meishan Zhao, Mingjun Shi, Jun Li, Yanchun Quan, Guangjian Fan*, Song Guo Zheng*, Bangmin Han*, Lianhui Sun*. Combination of porous Se@SiO2 nanospheres and docetaxel exhibits anti-castration-resistant prostate cancer activity by downregulating ATG14-dependent autophagy. Nano Today, 59 (2024) 102499.
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4. Jian Chen#, Deping Zhao#, Yupeng Wang#, Ming Liu, Yuan Zhang, Tingting Feng, Chao Xiao, Huan Song, Rui Miao, Li Xu, Hongwei Chen, Xiaoying Qiu, Yi Xu, Jingxuan Xu, Zelin Cui, Wei Wang, Yanchun Quan, Yifeng Zhu, Chen Huang, Song Guo Zheng, Jianyuan Zhao*, Ting Zhu*, Lianhui Sun*, Guangjian Fan *. Lactylated Apolipoprotein C-II Induces Immunotherapy Resistance by Promoting Extracellular Lipolysis. Advanced Science, 2024.2406333.
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5. Lianhui Sun#, Yuan Zhang#, Boyu Yang#, Simiao Sun, Pengshan Zhang, Zai Luo, Tingting Feng, Zelin Cui, Ting Zhu, Yuming Li, Zhengjun Qiu, Guanjian Fan*, and Huang Chen*. Lactylation of METTL16 promotes cuproptosis via m6A-modification on FDX1 mRNA in gastric cancer. Nature Communications, 2023 Oct 14:6523.
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6. Lianhui Sun#, Xing Wang#, Lixiao Chen#, Zheng Gao, Songhui Xu, Chen Hu, Guangjian Fan, Baoxin Wang, Tingting Feng*, Wang Wang*, Xinjiang Ying*. CPT1A mediates chemoresistance in human hypopharyngeal squamous cell carcinoma via ATG16L1-dependent cellular autophagy. Cell insight, 2023. Oct 11;2(6):100127.
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7. Lei Chen, Minglei Sha, Feiteng Chen, Chenyi Jiang, Deng Li, Chaoliang Xu, Deshen Pan, Zijie Xu, Qilin Tang, Shujie Xia, Lianhui Sun*, Guangjian Fan*, Yi Shao*. Upregulation of KLF14 expression attenuates kidney fibrosis by inducing PPARα-mediated fatty acid oxidation. Free Radic Bio Med. 2021 Feb 1; 195:132-144.
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8. Guangjian Fan#, Lianhui Sun#, Ling Meng #, Chen Hu, Xing Wang, Zhan Shi, Congli Hu, Yang Han, Qingqing Yang, Liu Cao, Xiaohong Zhang, Yan Zhang, Xianmin Song, Shujie Xia, Baokun He, Shengping Zhang*, Chuangui Wang*. The ATM and ATR kinases regulate centrosome clustering and tumor recurrence by targeting KIFC1 phosphorylation. Nature Communications. (2021) 12: 20.
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9. Jin Cheng#, Sijia He#, Min Wang, Ling Zhou, Zhengxiang Zhang, Xiao Feng, Yang Yu, Jingjing Ma, Chenyun Dai, Shengping Zhang, Lianhui Sun, Yanping Gong, Yiwei Wang, Minghui Zhao, Yuntao Luo, Xinjian Liu, Ling Tian, Chuanyuan Li*, Qian Huang*. Caspase-3/PKCδ/Akt/VEGF-A Signaling Pathway Mediates Tumor Repopulation during Radiotherapy. Clinical Cancer Research, 2019 Mar 19; 18:3001.
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10. Sijia He#, Jin Cheng#, Lianhui Sun#, Yiwei Wang, Chuangui Wang, Xinjian Liu, Zhengxiang Zhang, Minghui Zhao, Yuntao Luo, Ling Tian*, Chuanyuan Li*and Qian Huang*. HMGB1 released by irradiated tumor cells promotes living tumor cell proliferation via paracrine effect. Cell Death and Disease. 2018 May 29; 9:648.
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11. Peipei Shan#, Guangjian Fan#, Lianhui Sun#, Jinqin Liu, Weifang Wang, Chen Hu, Xiaohong Zhang, Qiwei Zhai, Xiaoyu Song, Liu Cao, Yongping Cui, Shengping Zhang* and Chuangui Wang*. SirT1 functions as a master regulator of poly (A) RNA transport under stress conditions. Current biology. 2017 Aug 7; 27:1-14.
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12. Lianhui Sun#, Guangjian Fan#, Peipei Shan#, Xiaoying Qiu, Shuxian Dong, Lujian Liao, Chunlei Yu, Tingting Wang, Xiaoyang Gu, Qian Li, Xiaoyu Song, Liu Cao, Xiaotao Li, Yongping Cui, Shengping Zhang* and Chuangui Wang*. Regulation of energy homeostasis by the ubiquitin-independent REGγ proteasome. Nature Communications, 2016 Aug 11; 7:12497.
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13. Guangjian Fan#, Lianhui Sun#, Peipei Shan#, Xianying Zhang, Jinliang Huan, Xiaohong Zhang, Dali Li, Tingting Wang, Tingting Wei, Xiaohong Zhang, Xiaoyang Gu, Liangfang Yao, Yang Xuan, Zhaoyuan Hou, Yongping Cui, Liu Cao, Xiaotao Li, Shengping Zhang* and Chuangui Wang*. Loss of KLF14 triggers centrosome amplification and tumorigenesis. Nature Communications, 2015 Oct 6; 6:8450.
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14. Shuxian Dong#, Caifeng Jia#, Shengping Zhang#, Guangjian Fan, Yubing Li, Peipei Shan, Lianhui Sun, Wenzhen Xiao, Lei Li, Yi Zheng, Jinqin Liu, Haibing Wei, Chen Hu, Wen Zhang, Y. Eugene Chin, Qiwei Zhai, Qiao Li, Jian Liu, Fuli Jia, Qianxing Mo, Dean P. Edwards, Shixia Huang, Lawrence Chan, Bert W. O’Malley, Xiaotao Li*, and Chuangui Wang*. The REGγ Proteasome Regulates Hepatic Lipid Metabolism through Inhibition of Autophagy. Cell Metabolism, 2013 Sep 3;18(3):380-91.
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15. Shibiao Wu, Jingjing Su, Lianhui Sun, Wenxuan Wang, Yun Zhao, Hui Li, Shengping Zhang, Guanghui Dai, Chuangui Wang, and Jinfeng Hu. Triterpenoids and Steroids from the Fruits of Melia toosendan and Their Cytotoxic Effects on Two Human Cancer Cell Lines. J Nat Prod. 2010 Nov 29;73 (11):1898-906.