起源1925年Robert W.Dawley将一只杂种雄性和一只雌性Wistar大鼠交配，得到该品系。
特征与用途
◇解剖：头部狭长，尾长接近于体长，产仔多，生长发育较Wistar快。
◇免疫：抗病能力强，尤其对呼吸道疾病的抵抗力强。
◇肿瘤：自发肿瘤发生率低。
◇生理：对性激素敏感性高。
◇用途：常用作营养学，内分泌学和毒理学等方面的研究。
饲料大小鼠繁殖料
来源于查氏瑞华大鼠的生长曲线：
来源于Taconic大鼠的生长曲线和生理指标：
SD Physiological Data Summary (April 2004; N=10/group):
ParameterUnitsSprague
Dawley® MalesSprague
Dawley® Females
|
|
|
|
Serum Chemistry |
Avg ± S.D. |
|
|
Calcium |
mg/dL |
12.3 ± 0.4 |
11.4 ± 3.5 |
Phosphorous |
mg/dL |
12.6 ± 1.1 |
12.4 ± 1.4 |
Glucose |
mg/dL |
82.4 ± 11.3 |
93.2 ± 10.3 |
Creatinine |
mg/dL |
0.3 ± 0.1 |
0.3 ± 0.1 |
BUN |
mg/dL |
9.1 ± 1.4 |
13.6 ± 3.0 |
Total Bilirubin |
mg/dL |
0.1 ± 0.0 |
0.1 ± 0.0 |
ALK |
U/L |
227.7 ± 36.1 |
142.5 ± 33.9 |
ALT U/L |
U/L |
29.3 ± 3.4 |
22.5 ± 3.9 |
Total Protein |
g/dL |
6.4 ± 0.2 |
6.7 ± 0.2 |
Blood Counts |
Erythron |
|
|
|
Red Blood Cells |
X106/uL |
6.9 ± 0.3 |
7.7 ± 0.3 |
Nucleated RBC |
X106/uL |
0 |
0 |
Hemoglobin |
g/dL |
14.5 ± 0.8 |
16.1 ± 0.6 |
Hematocrit |
% |
48.3 ± 2.3 |
51.2 ± 2.6 |
MCV |
fL |
69.9 ± 1.7 |
66.9 ± 0.9 |
MCH |
pG |
20.9 ± 1.3 |
21.0 ± 1.1 |
MCHC |
% |
29.9 ± 1.6 |
31.4 ± 1.9 |
Platelets |
|
|
|
Platelets |
X103/uL |
1358.0 ± 123.8 |
1262.2 ± 278.4 |
Leukogram |
|
|
|
White Blood Cells |
x103/uL |
9.4 ± 3.2 |
6.0 ± 1.5 |
Neutrophil |
x103/uL |
0.9 ± 0.5 |
0.4 ± 0.3 |
Bands |
x103/uL |
0 |
0 |
Lymphocyte |
x103/uL |
8.3 ± 2.9 |
5.5 ± 1.4 |
Monocytes |
x103/uL |
0.3 ± 0.3 |
0.1 ± 0.1 |
Eosinophil |
x103/uL |
0 |
0 |
Basophils |
x103/uL |
0 |
0 |
Others |
x103/uL |
0 |
0 |
Organ Weights |
|
|
|
Stomach |
g |
2.02 ± 0.12 |
1.54 ± 0.17 |
Ileum |
g |
6.19 ± 0.62 |
4.83 ± 0.35 |
Colon |
g |
0.77 ± 0.37 |
0.85 ± 0.21 |
Lungs |
g |
1.69 ± 0.14 |
1.31 ± 0.19 |
Heart |
g |
1.24 ± 0.14 |
0.90 ± 0.10 |
Liver |
g |
11.37 ± 1.12 |
7.17 ± 0.62 |
Spleen/Pancreas |
g |
1.58 ± 0.15 |
1.17 ± 0.23 |
Kidney (L) |
g |
1.08 ± 0.1 |
0.82 ± 0.08 |
Kidney (R) |
g |
1.09 ± 0.09 |
0.85 ± 0.08 |
Testes (L) |
g |
1.33 ± 0.17 |
- |
Testes (R) |
g |
1.33 ± 0.14 |
- |
Ovary (L) |
g |
- |
0.08 ± 0.01 |
Ovary (R) |
g |
- |
0.08 ± 0.01 |
Urinalysis |
|
|
|
Glucose |
mg/dL |
Negative |
Negative |
Blood |
- |
Negative |
Negative |
pH |
- |
6.75 ± 0.35 |
6.7 ± 0.4 |
Protein |
mg/dL |
N/A |
N/A |
Specific Gravity |
- |
1.0195 ± 0.0068 |
1.0155 ± 0.0079 |
One Year Growth Chart
Taconic Sprague Dawley® Rats Average Control Group Body Weight in Grams
One Year Toxicology Study (N=20)
Weeks of Age678910
|
|
|
|
|
|
Female |
152.71 |
184.13 |
209.71 |
227.55 |
241.11 |
Male |
163.01 |
225.98 |
276.15 |
306.93 |
336.53 |
Weeks of Age1112131415
|
|
|
|
|
|
Female |
256.33 |
260.37 |
271.94 |
279.08 |
291.5 |
Male |
361.71 |
378.11 |
396.8 |
412.86 |
431.21 |
Weeks of Age1617182226
|
|
|
|
|
|
Female |
295.22 |
298.41 |
303.42 |
315.48 |
335.41 |
Male |
441.56 |
454.14 |
461.01 |
491.98 |
514.05 |
Weeks of Age3034384246
|
|
|
|
|
|
Female |
350.74 |
357.83 |
368.19 |
383.44 |
392.05 |
Male |
528.94 |
544.33 |
556.88 |
568.96 |
568.41 |
Weeks of Age505458
|
|
|
|
Female |
408.44 |
421.01 |
426.79 |
Male |
579.1 |
584.42 |
577.79 |
来源于Charles River大鼠的生长曲线和生理指标：
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