Research
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  • Name:Qiang Zou

  • Office Location:Room 907, No.5 Bldg., West Area, 280 South Chongqing Rd., Shanghai

  • Telephone:86-021-64666150

  • Email:Qzou1984@126.com


Education


2003.09-2007.07 Shandong Agricultural University B.S.



2007.09-2012.01 China Agricultural University Ph.D.



Career

2012.03-2016.03 MD Anderson Cancer Center     Postdoctoral Fellow
2016.03-Present Shanghai Institute of Immunology, Shanghai Jiaotong University School of Medicine     Principal Investigator

Research Interests

T cells as pivotal effectors in antitumor immunity play a central role in cell-mediated tumor clearance. Specific metabolic programs are tightly controlled to mediate T cell immune responses. The research in our laboratory focuses on the metabolic mechanisms regulating antitumor T cell immunity. We are characterizing the crucial targets controlling T cell glucose metabolism and elucidating the metabolic mechanisms regulating T cell-mediated tumor immune response or tolerance. We will determine how to improve the efficiency of tumor immunotherapy by targeting glucose metabolism.


1.  Jiang H, Yu Z, Ding N, Yang M, Zhang L, Fan X, Zhou Y, Zou Q, Hou J, Zheng J, Zhang L, Xu Y, Liu J.The role of AGK in thrombocytopoiesis and possible therapeutic strategies.Blood,2020,Mar 20. pii: blood.2019003851.   [Link]

2.  Hu Z, Qu G, Yu X, Jiang H, Teng X-L, Ding L, Hu Q, Guo X, Zhou Y, Wang F, Li H-B, Chen L, Jiang J, Su B, Liu J, Zou Q.Acylglycerol Kinase Maintains Metabolic State and Immune Responses of CD8+ T Cells. Cell Metabolism,2019,30, 1–13.   [Link]

3.  Ouyang X, Han Y, Qu G, Li M, Wu N, Liu H, Arojo O, Sun H, Liu X, Liu D, Chen L, Zou Q, Su B. . Metabolic regulation of T cell development by Sin1-mTORC2 is mediated by pyruvate kinase M2.Journal of Molecular Cell Biology,2019,Feb 1;11(2):93-106.   [Link]

4.  Yu X, Teng X-L, Wang F, Zheng Y, Qu G, Zhou Y, Hu Z, Wu Z, Chang Y, Chen L, Li H-B, Su B, Lu L, Liu Z, Sun S-C, Zou Q.Metabolic control of regulatory T cell stability and function by TRAF3IP3 at the lysosome.The Journal of Experimental Medicine,2018,215(9):2463-2476..   [Link]

5.  Hu Z, Zou Q, Su B.Regulation of T cell immunity by cellular metabolism.Frontiers of Medicine,2018,Aug;12(4):463-472.   [Link]

6.  Yu X, Lao Y, Teng X-L, Li S, Zhou Y, Wang F, Guo X, Deng S, Chang Y, Wu X, Liu Z, Chen L, Lu L, Cheng J, Li B, Su B, Jiang J, Li H-B, Huang C, Yi J, Zou Q .SENP3 maintains the stability and function of regulatory T cells via BACH2 deSUMOylation.Nature Communications,2018,9:3157.   [Link]

7.  Lao Y, Yang K, Wang Z, Sun X, Zou Q, Yu X, Cheng J, Tong X, Yeh ETH, Yang J, Yi J.DeSUMOylation of MKK7 kinase by the SUMO2/3 protease SENP3 potentiates lipopolysaccharide-induced inflammatory signaling in macrophages.Journal of Biological Chemistry,2018,Mar 16;293(11):3965-3980.   [Link]


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Xiaoyan Yu,Ph.D.

Assistant Research Fellow

E-mail:yxypeony@163.com


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Xiao-Lu Teng,Ph.D.

Engineer

E-mail:txlcau@163.com


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Zhilin Hu,Ph.D.

Research Fellow

E-mail:15051523864@163.com


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Aiting Wang,Ph.D.

Research Fellow

E-mail:atwang@ips.ac.cn


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Yan Zhou,Ph.D.

Research Fellow

E-mail:zhouyan@cau.edu.cn


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Feixiang Wang

Ph.D. candidate

E-mail:wangflyxiang@163.com


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Zhongqiu Wu

Ph.D. candidate

E-mail:965095439@qq.com


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Rui Ding

M.S. candidate

E-mail:875483871@qq.com


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Xinwei Guo

B.S

E-mail:gloria980909@sjtu.edu.cn


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Min Ding

B.S

E-mail:malcolmln@163.com



Lab Location:Room 912, No.5 Bldg., West Area, 280 South Chongqing Rd., Shanghai

Tel:86-021-63846590-776662


                 

Copyright 2016. Shanghai Institute of Immunology,Shanghai Jiao Tong University School of Medicine.All Rights Reserved.