• Name:Lei Shen

  • Office Location:Room 1202, No.5 Bldg., 280 South Chongqing Rd.,Shanghai

  • Telephone:86-021-63846590-776365



1990-1995 Nanjing Medical University B.S.

1995-2000 Nanjing Medical University Ph.D.


2001-2005 Baylor College of Medicine     Postdoctoral Fellow
2005-2012 Stanford University     Senior Research Scientist
2012-present Shanghai Institute of Immunology, Shanghai Jiaotong University School of Medicine     Principal Investigator

Research Interests

The research interest of our group focuses on the interaction between the immune system and metabolism in the context such as  metabolic diseases (T2D etc.) where immune cells modulate metabolic tissue inflammation and whole-body metabolism, and immune cells development where cell-intrinsic metabolic programs control the fate and function of immune cells.  Our current research directions include:  1.To define the immune mechanisms of obesity-induced insulin resistance; 2. To decipher the metabolic programs that control Innate Lymphoid Cells (ILC) development and function.

1.  Shen L, Chng MH, Alonso MN, Yuan R, Winer DA, Engleman EG..B-1a Lymphocytes Attenuate Insulin Resistance.Diabetes,2015,64(2):593-603.   [Link]

2.  Shen L, Zhang H, Caimol M, Benike CJ, Chakravarty EF, Strober S, Engleman EG.Invariant natural killer T cells in lupus patients promote IgG and IgG autoantibody production.Eur J Immunol,2015,45(2):612-623.   [Link]

3.  McLaughlin T, Liu LF, Lamendola C, Shen L, Morton J, Rivas H, Winer D, Tolentino L, Choi O, Zhang H, Hui Yen Chng M, Engleman E.T-cell profile in adipose tissue is associated with insulin resistance and systemic inflammation in humans.Arterioscler Thromb Vasc Biol.,2014,34(12):2637-43.   [Link]

4.  Winer DA, Winer S, Chng MH, Shen L, Engleman EG..B Lymphocytes in obesity-related adipose tissue inflammation and insulin resistance..Cell Mol Life Sci,2014,71(6):1033-43.   [Link]

5.  Winer D* Winer S*, Shen L*, Wadia P, Yantha J, Paltser G, Tsui H, Wu P, Davidson M, Alonso M, Leong H, Glassford A, Caimol M, Tedder T, McLaughlin T, Miklos D, Dosch HM, Engleman EG.B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies..Nature Medicine,2011,17(5):610-7.   [Link]

6.  Zhang B, Lo C, Shen L, Sood R, Jones C, Cusmano-Ozog K, Park-Snyder S, Wong W, Jeng M, Cowan T, Engleman EG, Zehnder J..The role of Vanin-1 and oxidative stress-related pathways in distinguishing acute and chronic pediatric ITP.Blood,2011,117(17):4569-79.   [Link]

7.  Song XT, Evel-Kabler K, Shen L, Rollins L, Huang XF, Chen SY..A20 is an antigen presentation attenuator and its inhibition overcomes regulatory T cell-mediated suppression..Nature Medicine,2008,14(3):258-65.   [Link]

8.  Shen L, Evel-Kabler K, Strube R, Chen SY..Silencing of SOCS1 enhances antigen presentation by dendritic cells and antigen-specific anti-tumor immunity.Nature Biotechnology,2004,22:1546-1553.   [Link]

9.  Shen L, Schroers R, Hammer J, Huang XF, Chen SY.Identification of a MHC class II-restricted epitope in Carcinoembryonic antigen (CEA).Cancer Immunology and Immunotherapy,2004,53(5):391-403.   [Link]

10.  Schroers R, Shen L, Rollins L, Rooney CM, Slawin K, Sonderstrup G, Huang XF, Chen SY..Human telomerase reverse transcriptase-specific T helper responses induced by promiscuous MHC Class II-restricted Epitopes..Clinical Cancer Research,2003,9(13): 4743-4755.   [Link]

11.  Schroers R, Shen L, Rollins L, Xiao Z, Sonderstrup G, Slawin K, Huang XF, Chen SY..Identification of MHC class II-restricted epitopes in prostate-specific membrane antigen (PSMA).Clinical Cancer Research,2003,9(9):3260-3271.   [Link]

Jingjing Zhang

Ph.D. Candidate (Class 2016)

Hongshen Niu

M.S Candidate (Class 2015)

Zhe Ji,Ph.D.

Associate Professor

JingJing Qi,M.S

Assistant Research Fellow

Shuai Wu

Ph.D. Candidate (Class 2014)

Yaru Xu

Ph.D. Candidate (Class 2015)

Lab Location:Room 1201, No.5 Bldg., 280 South Chongqing Rd.,Shanghai



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