Research
  • undefined

  • Name: Yufeng Yao

    Office Location:280 South Chongqing Road, Room 710, West #5 Building, Shanghai, China 200025

    Telephone:86-21-63846590-776523

  • Email: yfyao@sjtu.edu.cn



Education  

· 1991.09-1995.07 Anhui Normal University

· 1995.09-1998.07 Nanjing Agricultural University

· 1998.09-2002.07 Shanghai Institutes for Biological Sciences, CAS

Career

· 2002.08-2004.09 National Institutes of Health, Postdoc

· 2004.09-2007.07 Johns Hopkins University SOM, Postdoc

· 2007.07- present Shanghai Jiao Tong University SOM, Faculty

· 2022.11- present Shanghai Institute of Immunology, PI


1. Wang Z, Tang H, Huang W, Wang C, Chen Y, Yu J, Zhou T, Wen B, Ni J, Wang D, Tao J, Zhu S, Lyu L, Chen L, Li J, Kuang Q, Yu D, Liu J, Pan L, Zhang M, Xu Y, Zhao GP, Lu J*, Yao YF*. Salmonella-derived heme inhibits macrophage phagocytosis and promotes infection in mice. Nat Microbiol. 2026.

2. Sun Z*, Dong C, Zhou P, Guan Q, Cui Z, Xia Y, Yao YF*. Type VI secretion system degeneration accelerates intestinal epithelial cell death in Escherichia coli O157:H7. PLoS Pathog. 2026, 22(3): e1014039.

3. Zhou X, Zhang H, Wang Y, Wang D, Lin Z, Zhang Y, Tang Y, Liu J, Yao Y*, Zhang Y*, Pan L*. Shigella effector IpaH1.4 subverts host E3 ligase RNF213 to evade antibacterial immunity. Nat Commun. 2025, 16(1):3099.

4. Tang H, Wang Z, Li C, Yu J, Huang W, Zhou T, Zhang C, Wen B, Wang C, Zhu C, Wang D, Tao J, Lu J, Ni J*, Yao YF*. Disruption of sulfur transferase complex increases bacterial intramacrophage persistence. PLoS Pathog. 2025, 21(5): e1013136.

5. Zhang C, Zhou T, Li C, Wang D, Tao J, Zhu C, Lu J, Ni J*, Yao YF*. Deciphering novel enzymatic and non-enzymatic lysine lactylation in Salmonella. Emerg Microbes Infect. 2025, 14(1): 2475838.

6. Yu J, Tang H, Chen Y, Wang Z, Huang W, Zhou T, Wen B, Wang C, Gu S, Ni J, Tao J, Wang D, Lu J*, Xie Q*, Yao YF*. Salmonella utilizes L-arabinose to silence virulence gene expression for accelerated pathogen growth within the host. Gut Microbes. 2025, 17(1): 2467187.

7. Zhou N, Yu J, Liu X, Li C, Tang H, Lyu L, Wu C, Chen Y, Zhang J, Ni J, Wang D, Tao J, Wu W, Zhang Y, Feng Y, Chao Y, Lu J*, He P*, Yao YF*. Within-host evolution of a transcriptional regulator contributes to the establishment of chronic Pseudomonas aeruginosa infection. Cell Rep. 2025, 44(1): 115214.

8. Yu J, Tang H, Zhou N, Wang Z, Huang W, Chen Y, Wang D, Ni J, Lu J*, Yao YF*. Dietary L-arabinose-induced gut dysbiosis exacerbates Salmonella infection outcome. mSystems. 2024, 9(8): e0052224.

9. Ni J, Li S, Lai Y, Wang Z, Wang D, Tan Y, Fan Y*, Lu J*, Yao YF*. Global profiling of ribosomal protein acetylation reveals essentiality of acetylation homeostasis in maintaining ribosome assembly and function. Nucleic Acids Res. 2023, 27;51(19): 10411-27.

10. Zhang W, Lyu L, Xu ZH, Ni J, Wang D, Lu J, Yao YF*. Integrative DNA methylome and transcriptome analysis reveals DNA adenine methylation is involved in Salmonella enterica Typhimurium response to oxidative stress. Microbiol Spectr. 2023, 26: e024792.

11. Tang H, Huang W, Yao YF*. The metabolites of lactic acid bacteria: classification, biosynthesis and modulation of gut microbiota. Microb Cell. 2023, 10(3): 49-62 (review).

12. Wang D, Ni J, Li J, Gao Y, Ni F, Zhang Z, Fang J, Lu J*, Yao YF*. Bacterial infection promotes tumorigenesis of colorectal cancer via regulating CDC42 acetylation. PLoS Pathog. 2023, 19(2): e1011189.

13. Wang Z, Zhu S, Li C, Lyu L, Yu J, Wang D, Xu Z, Ni J, Gao B, Lu J, Yao YF*, Gene essentiality profiling reveals a novel determinant of stresses preventing protein aggregation in Salmonella. Emerg Microbes Infect. 2022, 11(1):1554-1571

14. Sun Z, Zhou N, Zhang W, Xu Y, Yao YF*, Dual role of CsrA in regulating the hemolytic activity of Escherichia coli O157:H7. Virulence, 2022, 13(1):859-874

15. Su Y, Li J, Zhang W, Ni J, Huang R, Wang Z, Cheng S, Wang Y, Tian Z, Zhou Q, Lin D, Wu W, Christoph M, Liu X, Yao YF*, Methylation of phoP by CheR regulates Salmonella virulence. mBio. 2021, 12(5): e02099-21

16. Li J, Liu S, Su Y, Ren J, Ni J, Lu J, Yao YF*, Acetylation of PhoP K88 is involved in regulating Salmonella virulence. Infect Immun. 2021,89(3):e00588-20

17. Huang W, Wang D, Yao YF*, Understanding the pathogenesis of infectious diseases by single-cell RNA sequencing. Microb Cell. 2021, 8(9):208-222

18. Zhou A, Li J, Xu Z, Ni J, Guo J, Yao YF*, Wu W*. Whole-genome comparative and pathogenicity analysis of Salmonella enterica subsp. enterica serovar Rissen. G3:Genes Genomes Genetics. 2020, 10(7): 2159-70

19. Ren J, Sang Y, Qin R , Su Y, Cui Z, Mang Z, Li H, Lu S, Zhang J, Cheng S, Liu X, Li J, Lu J, Wu W, Zhao GP, Shao F, Yao YF*. Metabolic intermediate acetyl phosphate modulates bacterial virulence via acetylation. Emerg Microbes Infect. 2019, 8(1): 55-69

20. Xu Z, Zhou A, Wu J, Zhou A, Li J, Zhang S, Wu W, Karakousis PC, Yao YF*. Transcriptional approach for decoding the mechanism of rpoC compensatory mutations for the fitness cost in rifampicin-resistant Mycobacterium tuberculosis. Front Microbiol. 2018, 9:2895

21. Yu X, Fu F, Kong W, Xuan Q, Wen D, Chen X, He Y, He L, Guo J, Zhou A, Xi Y, Ni L, Yao YF*, Wu W*. Streptococcus agalactiae inhibits Candida albicans hyphal development and diminishes host vaginal mucosal TH17 response. Front Microbiol. 2018, 9:198

22. Ren J, Sang Y, Lu J, Yao YF*. 6S RNA is involved in acid resistance and invasion of epithelial cells in Salmonella enterica serovar Typhimurium. Future Microbiol. 2017, 12:1045-57

23. Ren J, Sang Y, Lu J, Yao YF*. Protein acetylation and its role in bacterial virulence. Trends Microbiol. 2017, 25(9):768-79 (invited review)

24. Li S, Zhang Q, Xu Z, Yao YF*. Acetylation of lysine 243 inhibits the oriC-binding ability of DnaA in Escherichia coli. Front Microbiol. 2017, 8:699

25. Sang Y, Ren J, Qin R, Liu S, Cui Z, Cheng S, Liu X, Lu J, Tao J*, Yao YF*. Acetylation regulating protein stability and DNA-binding ability of HilD, thus modulating Salmonella Typhimurium virulence. J Infect Dis. 2017, 216(8):1018-26 (cover story)

26. Wan B, Zhang Q, Ni J, Li S, Wen D, Li J, Xiao H, He P, Ou H, Tao J, Teng Q, Lu J, Wu W*, Yao YF*. Type VI secretion system contributes to Enterohemorrhagic Escherichia coli virulence by secreting catalase against host reactive oxygen species (ROS). PLoS Pathog. 2017, 13(3): e1006246

27. Qin R, Sang Y, Ren J, Zhang Q, Li S, Cui Z*, Yao YF*. The bacterial two-hybrid system uncovers the involvement of acetylation in regulating of Lrp activity in Salmonella Typhimurium. Front Microbiol. 2016, 7:1864

28. Zhang Q, Zhou A, Li S, Ni J, Tao J, Lu J, Wan B, Li S, Zhang J, Zhao S, Zhao GP, Shao F, Yao YF*. Reversible lysine acetylation is involved in DNA replication initiation by regulating activities of initiator DnaA in Escherichia coli. Sci Rep. 2016, 6:30837

29. Ren J, Sang Y, Tan Y, Tao J, Ni J, Liu S, Fan X, Zhao W, Lu J, Wu W, Yao YF*. Acetylation of lysine 201 inhibits the DNA-binding ability of PhoP to regulate Salmonella virulence. PLoS Pathog. 2016, 12(3):e1005458 (cover story)

30. Wan B, Zhang Q, Tao J, Zhou A, Yao YF*, Ni J*. Global transcriptional regulation by H-NS and its biological influence on the virulence of Enterohemorrhagic Escherichia coli. Gene. 2016, 588(2):115-23

31. Sang Y, Ren J, Ni J, Tao J, Lu J, Yao Y*. Protein acetylation is involved in Salmonella enterica serovar Typhimurium virulence and host inflammatory responses. J Infect Dis. 2016, 213 (11): 1836-45

32. Zhang Q, Wan B, Zhou A, Ni J, Xu Z, Li S, Tao J*, Yao YF*. Whole genome analysis of an MDR Beijing/W strain of Mycobacterium tuberculosis with large genomic 3 deletions associated with resistance to isoniazid. Gene. 2016, 582(2):128-36

33. Tan Y, Xu Z, Tao J, Ni J, Zhao W, Lu J, Yao YF*. A SIRT4-like auto ADP-ribosyltransferase is essential for the environmental growth of Mycobacterium smegmatis. Acta Bioch Bioph Sin. 2016, 48(2):145-52

34. Ren J, Yu S, Ni J, Tao J, Lu J, Zhao M*, Yao YF*. Acetylation regulates survival of Salmonella Typhimurium in acid stress. Appl Environ Microbiol. 2015, 81(17): 5675-82

35. Xu Z, Zhou A, Ni J, Zhang Q, Wang Y, Lu J, Wu W, Karakousis PC, Lu S*, Yao YF*. Differential expression of miRNAs and their relation to active tuberculosis. Tuberculosis. 2015, 95(4):395-403

36. Zhou A, Ni J, Xu Z, Wang Y, Lu S, W Wu, Karakousis PC, Yao YF*. Metabolomics specificity of tuberculosis plasma revealed by 1H-NMR spectroscopy. Tuberculosis. 2015, 95(3):294-302

37. Tao J, Sang Y, Teng Q, Ni J, Yang Y, Tsui S, Yao YF*. Heat shock proteins IbpA and IbpB are required for NlpI-participated cell division in Escherichia coli. Front Microbiol. 2015, 6:51

38. Zhou A, Ni J, Xu Z, Wang Y, Lu S, Sha W, Karakousis PC, Yao YF*. Application of 1H-NMR spectroscopy-based metabolomics to sera of tuberculosis patients. J Proteome Res. 2013, 12(10):4642-9

39. Zhou Y, Tao J, Yu H, Ni J, Zeng L, Teng Q, Kim KS, Zhao GP, Guo XK*, Yao YF*. Hcp-family proteins secreted via type VI secretion system coordinately regulate Escherichia coli K1 interaction with human brain microvascular endothelial cells. Infect & Immun, 2012, 80(3):1243-51


1


                 

Copyright 2016. Shanghai Institute of Immunology,Shanghai Jiao Tong University School of Medicine.All Rights Reserved.