Qiannan Tang-上海市免疫学研究所

Name:Qiannan Tang
Office Location:280 South Chongqing Road, Room 1001, West #5 Building, Shanghai, China 200025
Telephone:86-21-63846383
Email:qiannan.tang@sjtu.edu.cn

Education and work experience

2006-2010 BS, Shandong University

2010-2016 Ph.D, Institute of Biophysics, Chinese Academy of Sciences

2017-2020 Postdoctoral Scientist, MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford

2020-2022 Postdoctoral Scientist, Li Ka Shing Faculty of Medicine, The University of Hong Kong

2023-present Shanghai Jiao Tong University, Shanghai Institute of Immunology

Research Interests

Double-stranded DNA normally exists in the right-handed Watson-Crick B-form. The structure of Z-form DNA has a left-handed conformation, and was revealed by Alexander Rich in 1979. Double-stranded RNA can also adopt a Z-form. This unusual Z-form could be a hallmark of non-self nucleic acid to induce the immune response. The immunostimulatory potential of Z-nucleic acid was reported initially from 2017. It could be generated by viral infections or of endogenous origin.

However, the nature and biological function of them awaits further investigation. We thus to explore the origination and the biological function of this unique conformation in both pathogen invasions and sterile inflammation.

Apart from Z-nucleic acid, we will also try the possibility of the application of stem-cell technology into anti-tumor therapy.