Research

EAD8








Name:Yan Zhang

  • Office Location: 280 South Chongqing Road, Room 902, West #5 Building, Shanghai, China 200025

    Telephone: 021-63846590-776362

  • Email: zhy3331a@shsmu.edu.cn



Education:

B.S., China Pharmaceutical University, Nanjing, China      1999

Ph.D., Nanjing University, Nanjing, China (Mentor: Dr. Chenyu Zhang)    2003

Career:

2008-2014 Postdoctoral Fellow, National Cancer Institute, National Institutes of Health,  Bethesda, MD, USA (Mentor: Dr. Zhenggang Liu)

2016-2018 Staff Scientist, Children’s National Medical Center, Washington DC, USA

2018-2020  Research Associate, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, USA

2020-present Principal Investigator, Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China


Research Interests:

My research has focused on the fundamental mechanism of immune recognition and cancer biology, including both mechanisms that uncover the link between autoimmunity and cancer immunity, and on translating the new concept for production of new generation of cancer immunotherapeutic.

(1)Haoyue Zhou#, Jinmei Li#, Song Mei#, Meiyu Zhang, Kepeng Yan, Qunmin Zhou, Pan Zheng, Yang Liu, Peng Zhang*, Hecheng Li*, Wei Lu*, Yan Zhang*.Specific depletion of TIGIThigh CD226- clonally expanded intratumoral Tregs defines safe and effective TIGIT targeting. Journal for ImmunoTherapy of Cancer. 2026 Feb 24;14(2):e013636.

(2)Yu Hu#, Qifan Zhao#, Yingquan Qin#, Song Mei#, Benyu Wang, Haoyue Zhou, Linli Han , Yi Zang, Liangjiao Yao, Zhe He, Yingyi Li, Hecheng Li*, Peng Zhang*, Yan Zhang*, Michael J Lenardo*, Wei Lu*. CARD11 signaling regulates CD8+ T cell tumoricidal function. Nature Immunology. 2025 Jul;26(7):1113-1126.

(3)Meiyu Zhang#, Jinmei Li#, Kepeng Yan#, Haoyue Zhou, Song Mei, Benyu Wang, Dongyang Li, Xuexiang Du, Mingyue Liu, Peng Zhang, James K Fields, Lei Ye, Pan Zheng, Yang Liu, Michael J Lenardo*, Yan Zhang*. pH-dependent dissociation from CTLA-4 in early endosomes improves both safety and antitumor activity of anti-CTLA-4 antibodies. Proc Natl Acad Sci U S A. 2025 Feb 25;122(8):e2422731122.

(4)Zhenyi Niu, Ruisen Jin, Yan Zhang*, Hecheng Li*. Signaling pathways and targeted therapies in lung squamous cell car cinoma: mechanisms and clinical trials. Signal Transduct Target Ther. 2022 Oct 5;7(1):353.

(5)Pan Jia, Xiang Li, Xuelei Wang, Liangjiao Yao, Yingying Xu, Yu Hu, Wenwen Xu, Zhe He, Qifan Zhao, Yicong Deng, Yi Zang, Meiyu Zhang, Yan Zhang*, Jun Qin*, Wei Lu*. ZMYND8 mediated liquid condensates spatiotemporally decommission the latent super-enhancers during macrophage polarization. Nature Communications. 2021 Nov 11;12(1):6535.

(6)Wei Zheng#, Yan Zhang#, Jingjing Chen#, Yu Hu#, Pan Jia, Xuelei Wang, Qifang Zhao, Yicong Deng, Ni Li, Yi Zhang, Jun Qin,  Xiaoming Wang*, Wei Lu*. Pathogenic CARD11 mutations affect B cell development and differentiation through a noncanonical pathway. Science Immunology. 2019 Nov 29;4(41):eaaw5618.

(7)Yan Zhang#*, Xuexiang Du#, Mingyue Liu#, Fei Tang, Peng Zhang, Chunxia Ai, James K. Fields, Eric J. Sundberg, Olga S. Latinovic, Martin Devenport, Pan Zheng*, Yang Liu*. Hijacking Antibody-induced CTLA-4 Lysosomal Degradation for Safer and More Effective Cancer Immunotherapy, Cell Research. 2019 29: 609-627.

(8)Yan Zhang, Swati Choksi, Zhenggang Liu*. Butylated Hydroxyanisole Blocks the Occurrence of Tumor Associated Macrophages in Tobacco Smoke Carcinogen-Induced Lung Tumorigenesis. Cancers. 2013 5(4): 1643-1654.

(9)Yan Zhang, Swati Chokis, Kun Chen, Yelena Pobezinskaya, Ilona Linnoila, Zhenggang Liu*. ROS plays a critical role in the differentiation of alternatively activated macrophages and the occurrence of tumor associated macrophages, Cell Research. 2013 23: 898-914.

(10)Yan Zhang, Michael Morgan, Ken Chen, Swati Choksi, Zhenggang Liu*. Induction of Autophagy is Essential for Monocyte-Macrophage Differentiation. Blood. 2012 119(12): 2895-2905.




Lab Location:280 South Chongqing Road, Room 901, West #5 Building, Shanghai, China 200025

Tel:021-63846590-776795

Meiyu Zhang M.D

Assistant Research Fellow

E-mail:myzhang@shsmu.edu.cn

Kepeng Yan M.D

Assistant Research Fellow

E-mail:184499@shsmu.edu.cn

Song Mei

Postdoc(Class 2022)

E-mail:san.shiban@163.com

Jinmei Li

Ph.D. Candidate (Class 2021)

E-mail:18573136540@163.com

Benyu Wang
Ph.D.Candidate(Class 2022)
E-mail:wbysatm@sjtu.edu.cn
Haoyue Zhou
Ph.D. Candidate(Class 2023)
E-mail:zhyhhn@outlook.com
Dongyang Li
Ph.D.Candidate(Class 2024)
E-mail:ldy1563597114@sjtu.edu.cn
Haochen Zhao
M.S Candidate (Class 2024)
E-mail:zhaohc1120@outlook.com


                 

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