• Name:Huabing Li

  • Office Location:Room 602, No.5 Bldg., West Area, 280 South Chongqing Rd., Shanghai, China

  • Telephone:63846590 / 776662



2005-2011 Rutgers University / UMDNJ, Piscataway, NJ, USA, Ph.D.

2002-2005 Nankai University, Tianjin, China, M.S.

1999-2002 Nankai University, Tianjin, China, B.S.


2017-present Shanghai Institute of Immunology      Assistant Professor / Principal Investigator
2017-present Yale University School of Medicine     Assistant Professor Adjunct
2012-2017 Yale University     Post-Doctoral Fellow
2011-2012 Rutgers University     Post-Doctoral Associate
2006-2011 Rutgers University     Research Assistant
2002-2005 Nankai University     Research & Teaching Assistant

Research Interests

There are more than 100 types of different chemical RNA modification, among which m6A, m1A, m5C, pseudoUridine and APA are the major ones. HBL lab has made a series of pioneering discoveries in the m6A studies, won international reputations in the field, and laid solid experimental foundation. m6A research has been the frontier of the epigenetics field, but it is under explored for other types of RNA modifications, especially the cross-talks among those RNA modifications in response to environmental stimulation are unknown. Immune cells, especially T cells and macrophages in various inflammatory disease and tumor, provide an ideal perspective to explore this frontier. Combine mouse reverse genetics and state-of-art omics techniques, our research focuses on the following areas:

(1)  Function of m1A modification in T cells and macrophages;

(2)  Function of pseudoUridine modification in T cells and macrophages;

(3)  Function of APA modification in T cells and macrophages;

(4)  Develop inhibitors to those RNA modification and apply to tumor immunotherapy;

(5)  Cross-talks of those RNA modifications.

Lab Website:

1.  Tong J*, Cao G*, Zhang T*, Sefik E, Vesely M, Broughton J, Zhu S, Li H, Li B, Chen L, Chang HY, Su B, Flavell RA#, Li HB#.m6A mRNA methylation sustains Treg suppressive functions.Cell Research,2018,28: 253–256 .   [Link]

2.  Li HB*#, Tong J*, Zhu S*, Batista PJ, Duffy EE, Zhao J, Bailis W, Cao G, Kroehling L, Chen Y, Wang G, Broughton JP, Chen YG, Kluger Y, Simon MD, Chang HY, Yin Z#, Flavell RA#.m6A mRNA methylation controls T cell homeostasis by targeting IL-7/STAT5/SOCS pathway.Nature,2017,548(7667): 338-342.   [Link]

3.  Zhu S, Ding S, Wang P, Wei Z, Pan W, Palm NW, Yang Y, Yu H, Li HB et al.Nlrp9b inflammasome recognizes and restricts rotavirus infection in intestinal epithelial cells.Nature,2017,546(7660): 667-670.   [Link]

4.  Hu B*, Jin C*, Li HB*, Tong J, Ouyang X, Cetinbas NM, Zhu S, Strowig T, Lam FC, Zhao C, Henao-Mejia J, Yilmaz O, Fitzgerald KA, Eisenbarth SC, Elinav E, Flavell RA.The DNA Sensing Aim2 Inflammasome Controls Radiation Induced Cell death and Tissue Injury.Science,2016,354 (6313): 765-768.   [Link]

5.  Li HB.Chromosome Conformation Capture in Drosophila.Methods Mol. Biol,2016,1480:207-12.   [Link]

6.  Cao G*, Li HB*, Yin Z, Flavell RA. Recent advances in dynamic m6A RNA modification.Open Biology,2016,6(4): 160003.   [Link]

7.  Zhu S*, Li HB*, Flavell RA.Resemble and Inhibit: When RLR Meets TGF-β.Mol Cell,2014,56(6):719-20.   [Link]

8.  Li HB*, Jin C*, Chen Y*, Flavell RA.Inflammasome activation and metabolic disease progression. Cytokine Growth Factor Rev,2014,25(6):699-706.   [Link]

9.  Li HB, Ohno K, Gui H, and Pirrotta V.Insulators target active genes to transcription factories and Polycomb-repressed genes to PcG bodies.PLoS Genet,2013,9(4):e1003436.   [Link]

10.  Schwartz YB, Linder-Basso D, Kharchenko PV, Tolstorukov MY, Kim M, Li HB, Gorchakov AA, Minoda A, Shanower G, Alekseyenko AA, Riddle NC, Jung YL, Gu T, Plachetka A, Elgin SC, Kuroda MI, Park PJ, Savitsky M, Karpen GH, Pirrotta V.Nature and function of insulator protein binding sites in the Drosophila genome.Genome Res,2012,22(11): 2188-98.   [Link]

11.  Pirrotta V., and Li HB.A view of nuclear Polycomb bodies.Curr. Opin. Genet. Dev.,2012,22(2):101-9.   [Link]

12.  Li HB, Muller M, Bahechar I, Kyrchanova O, Ohno K, Georgiev P, and Pirrotta V. .Insulators, not Polycomb Response Elements, are required for long-range interactions between Polycomb targets in Drosophila.Mol. Cell. Biol,2011,31(4):616-25.   [Link]

JiYu Tong

Postdoctoral Fellow,2017

Ting Zhang

Postdoctoral Fellow,2017

Mei Yang,M.S

Associate Research Fellow

KaiQiong Mao,M.S

Assistant Research Fellow

JiaMeng Yao

M.S. student

YongBo Liu

Postdoctoral Fellow,2018

ZhiBin Yu

Postdoctoral Fellow,2018


Jing Wang

Postdoctoral Fellow,2018

ZheJun Chen

Visiting PhD student,2017

ShaoHui Wang

Visiting PhD student,2016

Lab Location:Room 610, No.5 Bldg., West Area, 280 South Chongqing Rd., Shanghai, China

Tel:63846590 / 776794


Copyright 2016. Shanghai Institute of Immunology,Shanghai Jiao Tong University School of Medicine.All Rights Reserved.