Research
  • Name:Jing Wang

  • Office Location:Room 603, No.5 BIdg, West Campus, 280 South Chongqing Rd. Shanghai

  • Telephone:021-63846590-776774

  • Email:jingwang@shsmu.edu.cn


Education


2001.9-2005.6 Naikai University B.S



2008.4-2011.3 Osaka University Ph.D



Career

2005.8-2008.3 Institute of microbiological diseases, Osaka university     Research assistant
2011.4-2013.6 Osaka University       Postdoctoral fellow
2013.8-2016.4 University of Calgary      Postdoctoral fellow
2016.5-2018.1 The University of Tokushima     Designated assistant Professor
2018.5- -present Shanghai Jiao Tong University School of Medicine       Research Fellow

Research Interests

inflammation, innate immune cells, intravital imaging

Research interest:
The lab's main research interest is to understand in vivo dynamics and functions of myeloid cells (neutrophils, macrophages etc) during inflammatory responses and how hematopoietic and non-hematopoietic components coordinate in complex tissues and organs. We incorporate several cutting-edge techniques such as intravital imaging, single cell sequencing and disease models to decipher the interactive behavior and functional outcome of myeloid cells in different tissue compartments.


1. Jin Wang#, Wenying Zhao#, Wenjuan Bai#, Dong Dong, Hui Wang, Xin Qi, Ajitha Thanabalasuriar, Youqiong Ye, Tian-le Xu, Hecheng Li, Paul Kubes, Bin Li,*and Jing Wang*. PIEZO1 mediates mechanical reprogramming of neutrophils for proangiogenic specialization in the lung, The Journal of Clinical Investigation, 2025 Jun 2; 135(11):e183796.


2.Xinqi Fan#; Yingjun Zhou#; Wenjuan Bai#;  Xue Li; Liyuan Lin; Huibin Lin; Ming Yang; Xiaofei Yu; Jing Wang; Liang Lin; Wei Wang ; Intravital Imaging of Translocated Bacteria via Fluorogenic Labeling of Gut Microbiota In Situ, Proceedings of the National Academy of Sciences, 2025 Feb 19; 122(13): e2415845122.


3. Wu X, Zhao X, Li F, Wang Y, Ou Y, Zhang H, Li X, Wu X, Wang L, Li M, Zhang Y, Liu J, Xing M, Liu H, Tan Y, Wang Y, Xie Y, Zhang H, Luo Y, Li H, Wang J, Sun L, Li Y, Zhang H*. MLKL-mediated endothelial necroptosis drives vascular damage and mortality in systemic inflammatory response syndrome. Cell Mol Immunol. 2024 Sep;21(11)1309-1321.


4. Guo W#, Li Z#, Anagnostopoulos G, Kong WT, Zhang S, Chakarov S, Shin A, Qian J, Zhu Y, Bai W, Cexus O, Nie B, Wang J, Hu X, Blériot C, Liu Z, Shen B, Venteclef N, Su B*, Ginhoux F*. Notch signaling regulates macrophage-mediated inflammation in metabolic dysfunction-associated steatotic liver disease. Immunity. 2024 Sep;57(10)2310-2327.e6


5. Kulle A#, Li Z#, Kwak A, Mancini M, Young D, Avizonis D, Groleau M, Baglole CJ, Behr MA, King IL, Divangahi M, Langais D, Wang J, Blagih J, Penz E, Dufour A, Thanabalasuriar A*. Alveolar macrophage function is impaired following inhalation of berry e-cigarette vapor. Proc Natl Acad Sci U S A., 2024 Oct; 121(40)


6. Ding T#, Wang Y#, Meng Y, Wu E, Shao Q, Lin S, Yu Y, Qian J, He Q, Zhang J*, Wang J*, Kohane DS*, Zhan C*. Reciprocal interaction with neutrophils facilitates cutaneous accumulation of liposomes. ACS Nano., 2024 Jul 1.


7. Kang H#, Liu L#, Wang Y, Bai W, Luo Y*, Wang J*. Neutrophil-macrophage communication via extracellular vesicle transfer promotes itaconate accumulation and ameliorates cytokine storm syndrome. Cell Mol Immunol., 2024 Jul;21(7):689-706


8. Wang Y#, Wang J#, Zhang J#, Wang Y, Wang Y, Kang H, Zhao W, Bai W, Miao N, Wang J. Stiffness sensing via Piezo1 enhances macrophages efferocytosis and promotes resolution of liver fibrosis. Sci. Adv., 2024, Jun 7; 10(23): eadj3289


9. Du X, Ren B, Li C, Li Q, Kan S, Wang X, Bai W, Wu C, Kassegne K, Yan H, Niu X, Yan M, Xu W, Wassmer S, Wang J*, Cheng G*, Wang Z*. PRL2 regulates neutrophil extracellular trap formation which contributes to severe malaria and acute lung injury. Nat Commun., 2024 Jan 29; 15(1):881


10. He J, Cao Y, Zhu Q, Wang X, Cheng G, Wang Q, He R, Lu H, Weng Y, Mao G, Bao Y, Wang J, Liu X, Han F, Shi P, Shen XZ. Renal macrophages monitor and remove particles from urine to prevent tubule obstruction. Immunity, 2024 Jan 9;57(1):106-123


11. Miao N, Wang J*. New insights into the role of the immune inhibitory receptor VSTM1 in autoimmune disease. Cell Mol Immunol., 2024 Jan;21(1): 95-96


12. Wang J, Dong D, Zhao W, Wang J*. Intravital microscopy visualizes innate immune crosstalk and function in tissue microenvironment. Eur J Immunol., 2023 Oct 13: e2350458


13. Wang YN, Wang YY, Wang J, Bai WJ, Miao NJ, Wang J*. Vinblastine resets tumor-associated macrophages toward M1 phenotype and promotes antitumor immune response. J Immunother Cancer., 2023 Aug;11(8):e007253


14. Zhao X, Li L, Sun H, Jiang X, Bai W, Wu N, Wang J, Su B. A novel reporter mouse line for studying alveolar macrophages. Sci China Life Sci., 2023 Jul 6


15. Huang D, Zhang C, Xiao M, Li X, Chen W, Jiang Y, Yuan Y, Zhang Y, Zou Y, Deng L, Wang Y, Sun Y, Dong W, Zhang Z, Xie L, Yu Z, Chen C, Liu L, Wang J, Yang Y, Yang J, Zhao Y, Zheng J. Redox metabolism maintains the leukemogenic capacity and drug resistance of AML cells. Proc Natl Acad Sci U S A., 2023 Mar 28;120(13)


16. Yang M, Jiang H, Ding C, Zhang L, Ding N, Li G, Zhang F, Wang J, Deng L, Liu J, Xu Y. STING activation in platelets aggravates septic thrombosis by enhancing platelet activation and granule secretion. Immunity, 2023 Mar 10


17. Miao N, Wang Z, Wang Q, Xie H, Yang N, Wan Y, Wang J, Kang H, Bai W, Wang Y, He R, Yan K, Wang Y, Hu Q, Liu Z, Li F, Wang F, Ginhoux F, Zhang X, Yin J*, Lu L*, Wang J*. Oxidized mitochondrial DNA induces gasdermin D oligomerization in systemic lupus erythematosus. Nat Commun., 2023 Feb 16;14(1):872


18. Xu Y, Wang J, Ren H, Dai H, Zhou Y, Ren X, Wang Y, Feng S, Deng X, Wu J, Fu T, Nie T, He H, Wei T, Zhu B, Hui L, Li B, Wang J, Wang H, Chen L, Shi X, Cheng X. Human Endoderm Stem Cells Reverse Inflammation-Related Acute Liver Failure through Cystatin SN-Mediated Inhibition of Interferon Signaling. Cell Research, 2023 Feb; 33(2):147-164



19. He H, Yang W, Su N, Zhang C, Dai J, Han F, Singhal M, Bai W, Zhu X, Zhu J, Liu Z, Xia W, Liu X, Zhang C, Jiang K, Huang W, Chen D, Wang Z, He X, Kirchhoff F, Li Z, Liu C, Huan J, Wang X, Wei W, Wang J, Augustin HG, Hu J. Activating NO-sGC crosstalk in the mouse vascular niche promotes vascular integrity and mitigates acute lung injury. J Exp Med. 2023 Feb 6;220(2):e20211422


20. Jia J, Wang M, Meng J, Ma Y, Wang Y, Miao N, Teng J, Zhu D, Shi H, Sun Y, Liu H, Cheng X, Su Y, Ye J, Chi H, Liu T, Zhou Z, Wan L, Chen X, Wang F, Zhang H, Ben J*, Wang J*, Yang C*, Hu Q*. Ferritin triggers neutrophil extracellular trap-mediated cytokine storm through Msr1 contributing to adult-onset Still’s disease pathogenesis. Nat Commun. 2022 Nov 10;13(1):6804 *co-correspondence author


21. Yu Y, Wang RR, Miao NJ, Tang JJ Zhang YW, Lu XR, Yan PY, Wang J, Jia XM. PD-L1 negatively regulates antifungal immunity by inhibiting neutrophil release from bone marrow. Nat Commun. 2022 Nov 11;13(1):6857


22. Wang J, Wang J*. Neutrophils, functions beyond host defense. Cell Immunol. 2022 Sep;379:104579


23. Wang Q, Zhu T, Miao N, Qu Y, Wang Z, Chao Y, Wang J, Wu W, Xu X, Xu C, Xia L, Wang F. Disulfiram bolsters T-cell anti-tumor immunity through direct activation of LCK-mediated TCR signaling. EMBO J. 2022 May 31:e110636


24. Wang Y, Wang J*. Intravital Imaging of Inflammatory Response in liver Disease. Front Cell Dev Biol. 2022 Jun 28;10:922041



25. An H, Qian C, Huang Y, Li J, Tian X, Feng J, Hu J, Fang Y, Jiao F, Zeng Y, Huang X, Meng X, Liu X, Lin X, Zeng Z, Guilliams M, Beschin A, Chen Y, Wu Y, Wang J, Oggioni MR, Leong J, Veening JW, Deng H, Zhang R, Wang H, Wu J, Cui Y, Zhang JR. Functional Vulnerability of Liver Microphages to Capsules Defines the Outcomes of Bacterial Septic Infections. J Exp Med. 2022 Apr 4;219(4):e20212032


26. Li G, Wang M, Ding T, Wang J, Chen T, Shao Q, Jiang K, Wang L, Yu Y, Pan F, Wang B, Wei X*, Qian J*, Zhan C. cRGD enables rapid phagocytosis of liposomal vancomycin for intracellular bacterial clearance. Journal of controlled release 2022 April 344, 202-213



27. Wang C, Zhang L, Sun Z, Yuan X, Wu B, Cen J, Cui L, Zhang K, Li C, Wu J, Shu Y, Sun W, Wang J, Hui L*. Dedifferentiation-associated inflammatory factors of long-term expanded human hepatocytes exacerbate their elimination by macrophages during liver engraftment. Hepatology 2022 Mar 1.



28. Li D, Xiong W, Wang Y, Feng J, He Y, Du J, Wang J, Yang M, Zeng H, Yang Y, Wu N, Chen S*, Dong Z* SLAMF3 and SLAMF4 are immune checkpoints that constrain macrophage phagocytosis of hematopoietic tumors. Sci Immunol. 2022 Jan 21;7(67)



29. Zhao D, Yang F, Wang Y, Li S, Li Y, Hou F, Yang W, Liu D, Tao Y, Li Q, Wang J*, He F*, Tang L*. ALK1 signaling is required for the homeostasis of Kupffer cells and prevention of bacterial infection. J Clin Invest. 2021 Dec 7:e150489 *co-correspondence author


30. Wang H, Ding T, Guan J, Liu X, Wang J, Jin P, Hou S, Lu W, Qian J, Wang W, and Zhan C*. Interrogation of folic acid-functionalized nanomedicines: The regulatory roles of plasma proteins reexamined. ACS Nano 2020, 14, 14779-14789


31. Yang X, Cheng X, Tang Y, Qiu X, Wang Z, Fu G, Wu J, Kang H, Wang J, Wang H, Chen F, Xiao X, Billiar T, Lu B*. The role of type 1 interferons in Gram-negative bacteria-induced coagulation. Blood 135 (14), 1087-1100, 2020


32. Bartneck M, Wang J*. Therapeutic Targeting of Neutrophil Granulocytes in Inflammatory Liver Disease. Front. Immunol.,10:2257, 2019



33. Wang J. Neutrophils in tissue injury and repair. Cell Tissue Res 371(3):531-539, 2018



34. Wang J*, Hossain M*, Thanabalasuriar A, Gunzer M, Meininger C, Kubes P. Visualizing the Function and Fate of Neutrophils in Sterile Injury and Repair. Science 358(6359): 111-116, 2017 * Contribute equally


35. Thanabalasuriar A, Neupane AS, Wang J, Krummel MF, Kubes P. iNKT cell emigration out of the lung vasculature requires neutrophils and monocyte-derived dendritic cells in inflammation. Cell Reports 16(12): 3260-72, 2016


36. Wang J, Kubes P. A Reservoir of Mature Cavity Macrophages that Can Rapidly Invade Visceral Organs to Affect Tissue Repair. Cell 165(3): 668-78, 2016


37. Slaba I, Wang J, Kolaczkowska E, McDonald B, Lee WY, Kubes P. Imaging the Dynamic Platelet-Neutrophil Response in Sterile Liver Injury and Repair in Mice. Hepatology 62(5): 1590-605, 2015


38. Watson RL, Buck J, Levin LR, Winger RC, Wang J, Arase H, Muller WA. Endothelial CD99 signals through soluble adenylyl cyclase and PKA to regulate leukocyte transendothelial migration. The Journal of Experimental Medicine 212(4): 447-56, 2015


39. Dal-Secco D*, Wang J*, Zeng Z, Kolaczkowska E, Wong C, Petri B, Ransohoff R, Charo I, Jenne C, Kubes P. A dynamic spectrum of monocytes arising from the in situ reprogramming of CCR2+ monocytes at a site of sterile injury. The Journal of Experimental Medicine 212(4): 447-56, 2015 *Contribute equally


40. Kishida K, Kohyama M, Kurashima Y, Wang J, Hirayasu K, Suenaga T, Kiyono H, Kunisawa J, Arase H. Negative regulation of DSS-induced experimental colitis by PILR. International Immunology 27(6): 307-14, 2015


41. Kuroki K*, Wang J*, Ose T*, Yamaguchi M*, Tabata S*, Maita N, Nakamura S, Kajikawa M, Kogure A, Satoh T, Arase H, Maenaka K. Structural basis for simultaneous recognition of an O-glycan and its attached peptide of mucin family by immune receptor PILR. Proceedings of the National Academy of Sciences 111(24): 8877-82, 2014* Contribute equally


42. Wang J*, Arase H. Regulation of immune response by neutrophils. Annals of the New York Academy of Sciences 1319: 66-81, 2014 *Correspondence author


43. Wang J, Shiratorri I, Uehori J, Ikawa M, Arase H. Neutrophil infiltration during inflammation is regulated by PILR via modulation of integrin activation. Nature Immunology 14: 34-40, 2013


44. Kogure A, Shiratori I, Wang J, Lanier LL, Arase H. PANP is a novel O-glycosylated PILRa ligand expressed in neural tissues. Biochemical and Biophysical Research Communications 405: 428-33, 2011


45. Arii J*, Wang J*, Morimoto T, Suenaga T, Akashi H, Arase H, Kawaguchi Y. A single-amino-acid substitution in herpes simplex virus 1 envelope glycoprotein B at a site required for binding to the paired immunoglobulin-like type 2 receptor a (PILRa) abrogates PILRa-dependent viral entry and reduces pathogenesis. Journal of Virology 84: 10773-10783, 2010 *Contribute equally


46. Wang J, Fan Q, Satoh T, Arii J, Lanier LL, Spear PG, Kawaguchi Y, Arase H. Binding of herpes simplex virus glycoprotein B (gB) to paired immunoglobulin-like type 2 receptor a depends on specific sialylated O-linked glycans on gB. Journal of Virology 83: 13042-13045, 2009


47. Satoh T, Arii J, Suenaga T, Wang J, Kogure A, Uehori J, Arase N, Shiratori I, Tanaka S, Kawaguchi Y, Spear PG, Lanier LL, Arase H. PILRa is a herpes simplex virus-1 entry coreceptor that associates with glycoprotein B. Cell 132: 935-944, 2008


48. Tabata S, Kuroki K, Wang J, Kajikawa M, Shiratori I, Kohda D, Arase H, Maenaka K. Biophysical characterization of O-glycosylated CD99 recognition by paired Ig-like type 2 receptors. Journal of Biological Chemistry 283: 8893-8901, 2008


49. Wang J, Shiratori I, Satoh T, Lanier LL, Arase H. An essential role of sialylated O-linked sugar chains in the recognition of mouse CD99 by paired Ig-like type 2 receptor (PILR). Journal of Immunology 180: 1686-1693, 2008


50. Tabata S, Kuroki K, Maita N, Wang J, Shiratori I, Arase H, Kohda D, Maenaka K. Expression, crystallization and preliminary X-ray diffraction analysis of human paired Ig-like type 2 receptor alpha (PILRa). Acta Crystallographica Section F: Structural Biology and Crystallization Communications 64: 44-46, 2008


ED45



Jiangxue Li Ph.D.


Associate Professor



1EBDC



Yuanyuan Wang M.S.


Technician





D98B



Hui Wang



Technician


43151



Jin Wang

Ph.D Candidate
 (Class2019)


27809



Wenying Zhao

Ph.D Candidate  (Class2021)


14804



Jiahao Zhang

Ph.D Candidate
(Class2022)


5246



Yeke Huang

M.S. Candidate
(
Ruijin Hospital)


B781




Xiaotian Chen

Ph.D Candidate
(Class2024)


18738



Qianqian Zhao

M.D. Candidate 
(Ruijin Hospital)


406A




Tanglin Liu

Ph.D Candidate
(Class2024)














                 

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