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  • Name:Ying Wang

  • Office Location:Room 1208, No.5 Bldg., 280 South Chongqing Rd., Shanghai

  • Telephone:86-021-63846590-776319



1991 Fudan University B.S.

2000 Shanghai Jiaotong University School of Medicine M.Ph.

2005 University of Mediterranean in Marseille, France Ph.D.

2006 Shanghai Jiaotong University School of Medicine Ph.D.


1991-1996 Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine     Teaching Assistant
1996-2002 Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine     Lecturer
2002-2013 Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine     Associate Professor
2013-present Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine     Professor
2012-2014 Faculty of Basic Medicine, Shanghai Jiao Tong University School of Medicine     Vice Dean
2014-present Graduate School of Medicine, Shanghai Jiao Tong University School of Medicine     Vice Dean

Research Interests

My research interest is the study on immunological mechanism and preventive strategies against diseases such as infectious tuberculosis (TB) and autoimmune diseases such as system lupus erythematosus (SLE). I have been working on the exploration of diagnostic biomarkers and development of novel preventive vaccines against TB and latent TB infection. We have screened panels of novel mycobaceterial antigens with high immunogenencity both in active TB patients and mice, which facilitates their further expectation for vaccine development and biomarker determination. I am also working on molecular mechanisms of dysfunctional T cell immune responses in SLE where I mainly focus on the mechanisms of T-B interaction by using a unique mechanic system to calculate the adhesion of multiple molecular pairs in T-B interaction, which might provide quantitative criteria for the selection of therapeutic targets in clinic.

1.  Fan J, Zhang Y, Xiong H*, Wang Y*, Guo X..Nucleotide analog-resistant mutations in hepatitis B viral genomes found in hepatitis B patients. J Gen Virol,2015,96(Pt 3):663-70..   [Link]

2.  Xu J, Wu B, Wang JH, Huang L, Wang DY, Zhao L, Zhao GP, Wang Y*.Pre-existing mutations in reverse transcriptase of hepatitis B virus in treatment-naive chinese patients with chronic hepatitis B.PLoS One,2015,10(3): e0117429.   [Link]

3.  Wang S, Zhang Y, Saas P, Wang H, Xu Y, Chen K, Zhong J, Yuan Y, Wang Y* and Sun Y*.Oridonin exerts therapeutic effect by suppressing Th1/Th17 simultaneously in a mouse model of Crohns disease..J Gastroenterol Hepatol.,2015,30: 504-512.   [Link]

4.  Fan J, Wang Y, Xiong H, Guo X, Cheng YC.Impact of the rtI187V polymerase substitution of hepatitis B virus on viral replication and antiviral drug susceptibility..J Gen Virol,2014,95(Pt 11):2523-30.   [Link]

5.  Rao W, Li H, Song F, Zhang R, Yin Q, Wang Y, Xi Y, Ge H..OVA66 increases cell growth, invasion and survival via regulation of IGF-1R-MAPK signaling in human cancer cells.Carcinogenesis,2014,35(7):1573-81.   [Link]

6.  Rao W, Xie G, Zhang Y, Wang S, Wang Y, Zhang H, Song F, Zhang R, Yin Q, Shen L, Ge H.OVA66, a tumor associated protein, induces oncogenic transformation of NIH3T3 cells.PLoS One,2014,9(3):e85705.   [Link]

7.  Zhang F, Zhou X, DiSpirito JR, Wang C, Wang Y, Shen H.Epigenetic manipulation restores functions of defective CD8(+) T cells from chronic viral infection.Mol Ther,2014,22(9):1698-706.   [Link]

8.  Zeng W, Wang Y, Liu Z, Khanniche A, Hu Q, Feng Y, Ye W, Yang J, Wang S, Zhou L, Shen H, Wang Y.Long-term exposure to decabrominated diphenyl ether impairs CD8 T-cell function in adult mice.Cell Mol Immunol.,2014,11(4):367-76.   [Link]

9.  Xiong FF, Xia LL, Wang JF, Wu B, Wang DY, Yuan LF, Cheng YT, Zhu HY, Che XY, Zhang QH, Zhao GP, Wang Y*.A High-affinity CDR-grafted Antibody against Influenza A H5N1 Viruses Recognizes a Conserved Epitope of H5 Hemagglutinin.PLoS One,2014,9(2):e88777.   [Link]

10.  Zhang Y, Ye WY, Wang JQ, Wang SJ, Ji P, Zhou GY, Zhao GP, Ge HL, Wang Y*.dCTP Pyrophosphohydrase Exhibits Nucleic Accumulation in Multiple Carcinomas.Eur J Histochemistry,2013,57(e29): 185-191.   [Link]

11.  Wang Y* and Wang XN*.Cell-in-cell: A virgin land of cell biology.OncoImmunology,2013,2(10): e25988.   [Link]

12.  Wang S, He MF, Chen YH, Wang MY, Yu XM, Bai J, Zhu HY, Wang YY, Zhao H, Mei Q, Nie J, Ma J, Wang JF, Wen Q, Ma L, Wang Y* and Wang XN*.Rapid reuptake of granzyme B leads to emperitosis: an apoptotic cell-in-cell death of immune killer cells inside tumor cells.Cell Death & Disease,2013,4:e856.   [Link]

13.  He MF, Wang S, Wang Y*, Wang XN*.Modeling cell-in-cell structure its biological significance.Cell Death & Disease,2013,4:e630.   [Link]

14.  Chen YH, Wang S, He MF, Wang Y, Zhao H, Zhu HY, Yu XM, Ma J, Che XJ, Wang JF, Wang Y*, Wang XN*.Prevalence of Heterotypic Tumor/Immune Cell-In-Cell Structure In Vitro and In Vivo Leading to Formation of Aneuploidy.PLoS One,2013,8(3):e59418.   [Link]

15.  Ouyang S, Gong B, Li JZ, Zhao LX, Wu W, Zhang FS, Sun L, Wang SJ, Pan M, Li C, Liang W, Shaw N, Zheng J, Zhao GP, Wang Y*, Liu ZJ*, Liang M*..Structural insights a human anti-IFN antibody exerting therapeutic potential for systemic lupus erythematosus. J Mol Med (Berl).,2012,90(7):837-46.   [Link]

16.  He M, Wang Y, Shi WJ, Wang SJ, Sha HF, Feng JX, Wang J. .Immunomodulation of inducible co-stimulator (ICOS) in human cytokine-induced killer cells against cholangiocarcinoma through ICOS/ICOS ligand interaction.J Dig Dis,2011,12(5):393-400.   [Link]

17.  Wu X, Feng QM, Wang Y, Shi J, Ge HL, Di W.The immunologic aspects in advanced ovarian cancer patients treated with paclitaxel and carboplatin chemotherapy.Cancer Immunol Immunother,2010,59(2):279-91.   [Link]

18.  Wang J, He M, Shi W, Sha H, Feng J, Wang S, Wang Y.Inducible costimulator (ICOS) enhances the cytolytic activity of cytokine-induced killer cells against gallbladder cancer in vitro and in vivo.Cancer Invest, 2009,27(3):244-50.   [Link]

19.  Li HW, Li JZ, Zhao GP, Wang Y*.Current research status of immunology in the genomic era.SCIENCE CHINA Life Sciences,2009,52 (1): 43-49.   [Link]

20.  Mingueneau M, Roncagalli R, Gregoire C, Kissenpfennig A, Miazek A, Archambaud C, Wang Y, Perrin P, Bertosio E, Sansoni A, Richelme S, Locksley RM, Aguado E, Malissen M, Malissen B.Loss of the LAT adaptor converts antigen-responsive T cells pathogenic effectors that function independently of the T cell receptor. Immunity,2009,31(2):197-208.   [Link]

21.  Wang Y, Kissenpfennig A, Mingueneau M, Richelme S, Perrin P, Chevrier S, Genton C, Lucas B, DiSanto JP, Acha-Orbea H, Malissen B, Malissen M.Th2 lymphoproliferative disorder of LatY136F mutant mice unfolds independently of TCR-MHC engagement and is insensitive to the action of Foxp3+ regulatory T cells..J Immunol,2008,180(3):1565-75.   [Link]

22.  Wang Q, Li M, Wang Y, Zhang Y, Jin S, Xie G, Liu Z, Wang S, Zhang H, Shen L, Ge H..RNA interference targeting CML66, a novel tumor antigen, inhibits proliferation, invasion and metastasis of HeLa cells..Cancer Lett,2008,269(1):127-38..   [Link]

23.  Jin S, Wang Y#, Zhang Y, Zhang HZ, Wang SJ, Tang JQ, Chen HJ, Ge HL..Humoral immune responses against tumor-associated antigen OVA66 originally defined by serological analysis of recombinant cDNA expression libraries and its potentiality in cellular immunity.Cancer Sci,2008,99(8):1670-8..   [Link]

24.  Gregoire C, Simova S, Wang Y, Sansoni A, Richelme S, Schmidt-Giese A, Simeoni L, Angelisova P, Reinhold D, Schraven B, Horejsi V, Malissen B, Malissen M.Deletion of the LIME adaptor protein minimally affects T and B cell development and function. Eur J Immunol,2007,37(11):3259-69.   [Link]

25.  Malissen B, Wang Y, Mingueneau M, Malissen M..Th2 lymphoproliferative disorders resulting from defective LAT signalosomes..Novartis Found Symp,2007,281:93-100.   [Link]

26.  Ge HL, Wang Y, Wang SJ et al..Identification of melanoma-specific peptide epitopes by HLA-A2.1-restricted cytotoxicity T lymphocytes..Acta Biochim Bioph Sin,2006,38(2):110-118.   [Link]

27.  Genton C, Wang Y, Izui S, Malissen B, Delsol G, Fournié GJ, Malissen M, Acha-Orbea H..The TH2 lymphoproliferative disorder developing in LatY136F mutant mice triggers polyclonal B-cell activation and lupus-like autoimmunity..J Immunol,2006,177: 2285–2293.   [Link]

28.  Wang Y, Hilgert I, Hamm-Baarke A, et al..Single and combined deletions of the NTAL/LAB and LAT adaptors minimally affect B cell development and function..Mol Cell Biol.,2005,25(11):4455-65..   [Link]

29.  Prinz I, Gregoire C, Mollenkopf H, Aguado E, Wang Y, Malissen M, Kaufmann S & Malissen B..The type 1 cysteinyl-leukotriene receptor triggers calcium influx and chemotaxis in mouse αβ- and γδ-effector T cells..J Immunol.,2005,175(2):713-9. .   [Link]

30.  Yang C#, Khanniche A#, DiSpirito JR, Ji P, Wang S, Wang Y*, Shen H*.Transcriptome Signatures Reveal Rapid Induction of Immune-Responsive Genes in Human Memory CD8(+) T Cells..Sci Rep.,2016,6:27005.   [Link]

31.  Ji P#, Zhang Y#, Wang SJ, Ge HL, Zhao GP, Xu YC, Wang Y*..CD44hiCD24lo mammosphere-forming cells from primary breast cancer display resistance to multiple chemotherapeutic drugs..Oncol Rep.,2016,35(6):3293-302.   [Link]

32.  Xiao XJ#, Sha W#, Tian ZF#, Chen YY, Ji P, Sun Q, Wang HY, Wang SJ, Fang Y, Wen HL, Zhao HM, Lu J, Xiao HP, Fan XY*, Shen H* and Wang Y*.Adenylate kinase: a novel antigen for immunodiagnosis and subunit vaccine against tuberculosis.J Mol Med,2016,Feb 23.   [Link]

33.  Wang Y, Wang XD*.Entosis and Related Forms of Cell Death within Cells..Curr Mol Med.,2015,15(9):805-9.   [Link]

34.  Zhou A, Ni J, Xu Z, Wang Y, Zhang H, Wu W, Lu S, Karakousis PC, Yao YF*. .Metabolomics specificity of tuberculosis plasma revealed by 1H NMR spectroscopy..Tuberculosis (Edinb).,2015,S1472-9792(14)20681.   [Link]

35.  Ni C#, Chen YH#, Zeng MS#, Pei RJ, Du Y, Tang LQ, Wang MY, Hu YJ, Zhu HY, He MF, Wei XW, Wang S, Ning XK, Wang MN, Wang JF, Ma L,Chen XW, Sun Q, Tang H, WangY* and Wang XN*.In-cell infection: a novel pathway for Epstein-Barr virus infection mediated by cell-in-cell structures..Cell Research,2015,25(7):785-800.   [Link]

36.  Song FF#, Xia LL#, Ji P#, Tang YB, Huang ZM, Zhu L, Zhang J, Wang JQ, Zhao GP, Ge HL, Zhang Y*, Wang Y*.Human dCTP Pyrophosphatase 1 promotes breast cancer cell growth and stemness through modulation on 5-methyl-dCTP metabolism and global hypomethylation..Oncogenesis.,2015,4:e159.   [Link]

37.  Lin X, Liang Q, Lin L, Ding Q, Wang X, Wang Y*..Identification of anti-moesin antibodies in the serums of patients with antiphospholipid syndrome.Thromb Res. ,2015 ,135: 867-878.   [Link]


Shu-jun Wang,M.S

Senior Engineer


Ping Ji,B.S



Ying-ying Chen



Mei-yu Zhang

Ph.D. Candidate (Grade 2012)


Yong Li

Ph.D. Candidate (Grade 2012)


Asma Khanniche

Ph.D. Candidate (Grade 2012)


Jia-bao Wu

Master. Candidate (Grade 2014)


Jia-ni Xiao

Ph.D. Candidate (Grade 2015)


Shuai Liu

Master. Candidate (Grade 2015)

Lab Location:Room 1211, No.5 Bldg., 280 South Chongqing Rd., Shanghai



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