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  • Name:Zhiduo Liu

  • Office Location:Room 107, No.7 Bldg., West Area, 280 South Chongqing Rd., Shanghai

  • Telephone:021-63846590-776749



1997-2001 WuHan University B.S.

2001-2009 Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences. Ph.D.


2010-2016 National Institutes of Health     Postdoctoral Fellow
2016-Present Shanghai Institute of Immunology, Shanghai Jiaotong University School of Medicine       Principal Investigator

Research Interests

The microenvironment, where multiple cell types interact with each other for their self-renewal or certain function, represents those rare but biologically meaningful hotspots throughout anatomically heterogeneous tissues. I am particularly interested in employing different tools, including the state-of-art imaging, for the revelation and dissection of immune microenvironment under physiological or inflammatory conditions in the peripheral tissues, such as gut and lung.

1.  Liu Z*, Gerner MY, Van Panhuys N, Levine AG, Rudensky AY, Germain RN..Immune homeostasis enforced by co-localized effector and regulatory T cells..Nature.,2015,528(7581):225-30..   [Link]

2.  Yu X, Teng X-L, Wang F, Zheng Y, Qu G, Zhou Y, Hu Z, Wu Z, Chang Y, Chen L, Li H-B, Su B, Lu L#, Liu Z#, Sun S-C#, Zou Q#..Metabolic control of regulatory T cell stability and function by TRAF3IP3 at the lysosome..Journal of Experimental Medicine. ,2018,215(9):2463-2476..   [Link]

3.  Liu Z, Gu Y, Chakarov S, Bleriot C, Kwok I, Chen X, Shin A, Huang W, Dress RJ, Dutertre CA, Schlitzer A, Chen J, Ng LG, Wang H, Liu Z, Su B, Ginhoux F. .Fate Mapping via Ms4a3-Expression History Traces Monocyte-Derived Cells..Cell.,2019,178(6):1509-1525.e19..   [Link]

4.  Yu X, Lao Y, Teng X-L, Li S, Zhou Y, Wang F, Guo X, Deng S, Chang Y, Wu X, Liu Z, Chen L, Lu L, Cheng J, Li B, Su B, Jiang J, Li H-B, Huang C, Yi J, Zou Q..SENP3 maintains the stability and function of regulatory T cells via BACH2 deSUMOylation..Nature Communications.,2018,9(1):3157..   [Link]

5.  Oyler-Yaniv A, Oyler-Yaniv J, Whitlock BM, Liu Z, Germain RN, Huse M, Altan-Bonnet G, Krichevsky O. .A Tunable Diffusion-Consumption Mechanism of Cytokine Propagation Enables Plasticity in Cell-to-Cell Communication in the Immune System..Immunity.,2017,46(4):609-620..   [Link]

6.  Veres TZ, Kopcsányi T, van Panhuys N, Gerner MY, Liu Z, Rantakari P, Dunkel J, Miyasaka M, Salmi M, Jalkanen S, Germain RN. .Allergen-Induced CD4+ T Cell Cytokine Production within Airway Mucosal Dendritic Cell-T Cell Clusters Drives the Local Recruitment of Myeloid Effector Cells..Journal of Immunology.,2017,198(2):895-907..   [Link]

7.  Lo B, Zhang K, Lu W, Zheng L, Zhang Q, Kanellopoulou C, Zhang Y, Liu Z, Fritz JM, Marsh R, Husami A, Kissell D, Nortman S, Chaturvedi V, Haines H, Young LR, Mo J, Filipovich AH, Bleesing JJ, Mustillo P, Stephens M, Rueda CM, Chougnet CA, Hoebe K, McElwee J, Hughes JD, Karakoc-Aydiner E, Matthews HF, Price S, Su HC, Rao VK, Lenardo MJ, Jordan MB..Patients with LRBA deficiency show CTLA4 loss and immune dysregulation responsive to abatacept therapy. .Science.,2015,349(6246):436-40..   [Link]

8.  Li Z, Zhang Y, Liu Z, Wu X, Zheng Y, Tao Z, Mao K, Wang J, Lin G, Tian L, Ji Y, Qin M, Sun S, Zhu X, Sun B. .ECM1 controls T(H)2 cell egress from lymph nodes through re-expression of S1P(1). .Nature Immunology.,2011,12(2):178-85..   [Link]

9.  Liu Z*, Li Z*, Mao K, Zou J, Wang Y, Tao Z, Lin G, Tian L, Ji Y, Wu X, Zhu X, Sun S, Chen W, Xiang C, Sun B..Dec2 promotes Th2 cell differentiation by enhancing IL-2R signaling..Journal of Immunology.,2009,183(10):6320-9..   [Link]


Siming Liu,Ph.D.

Assistant Research Fellow


Wenjing Yu,M.S



Xin Chen

2018 Ph.D. Canidate(2016 M.S. Candidate)


Shiqi Yang

2017 M.S. Candidate


Mengyao Li

2018 M.S. Candidate


Yao Ma

2019 M.S. Candidate


Yuhan Zheng


Lab Location:Room 107, No.7 Bldg., West Area, 280 South Chongqing Rd., Shanghai



Copyright 2016. Shanghai Institute of Immunology,Shanghai Jiao Tong University School of Medicine.All Rights Reserved.